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Glial Cells Missing Homolog 2 (Drosophila) Proteins (GCM2)

GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. Additionally we are shipping GCM2 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCM2 9247 O75603
GCM2 107889 O09102
Rat GCM2 GCM2 291047  
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Top GCM2 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

GCM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Glial Cells Missing Homolog 2 (Drosophila) (GCM2) Interaction Partners

Zebrafish Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac (show TRPV6 Proteins)-expressing ionocytes and Ca2 (show CA2 Proteins)+ uptake.

  2. PTH1 (show PTH Proteins) morphants failed to express gcm2. Coinjection of PTH1 (show PTH Proteins) morpholino with gcm2 capped RNA rescued the phenotypes observed in the PTH1 (show PTH Proteins) morphants, suggesting that the defects in PTH1 (show PTH Proteins)-deficient fish were caused, at least in part, by the suppression of gcm2.

  3. Results suggest that an acquisition of enhancers for the expression of gcm2 contributes to a diversity of ionocytes in zebrafish during evolution.

  4. role of Shh (show SHH Proteins) signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  5. Results suggest a role for glial cells missing 2 during the evolution of divergent pharyngeal morphologies.

  6. Gcm-2 is required for the formation of the internal gill buds in zebrafish

  7. The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase (show ATP6AP1 Proteins)-rich cells in zebrafish.

Human Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. Gata3 (show GATA3 Proteins) interacted with Gcm2 and MafB (show MAFB Proteins), two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH (show PTH Proteins) promoter.

  2. The higher frequency of GCM2 282D in primary hyperparathyroidismand enhanced transcriptional activity of this variant supports the notion that it could contribute causally to parathyroid tumorigenesis

  3. we identified the genetic defect in 35% of hypoparathyroidism patients in our cohort and discovered novel GCM2 mutations including submicroscopic deletion that was undetectable by array comparative genomic hybridization

  4. Four single nucleotide polymorphisms of GCMB gene were found in the GCMB gene (c.-44T > C [rs16870746], c.91-242A > G [rs9379881], c.343+163G > A [rs9393726], and c.583-72A > T [rs2076257]) in our cohort.

  5. First described GCM2 mutation in exon 3 in patients with severe congenital hypoparathyroidism.

  6. Data suggest that replacement of cysteine 106 with arginine (C106R) would interfere with DNA binding of glial cells missing B (GCMB).

  7. We conclude that mutations in the transcription factor GCMB do not seem to play a major role in the pathogenesis of primary hyperparathyroidism.

  8. These results indicate that GCMB and vitamin D receptor (show VDR Proteins) are involved in the positive and negative regulation of parathyroid hormone (show PTH Proteins) gene expression, respectively.

  9. Gcm2 is a useful adjunct marker for the diagnosis of parathyroid lesions.

  10. Our results have identified the first dominant missense GCMB mutation and help to increase our understanding of the mechanism underlying gene transactivation that is a prerequisite for the function of this parathyroid gland-specific transcription factor.

Mouse (Murine) Glial Cells Missing Homolog 2 (Drosophila) (GCM2) interaction partners

  1. results suggest that MafB (show MAFB Proteins) regulates later steps of parathyroid development, that is, separation from the thymus and migration toward the thyroid. MafB (show MAFB Proteins) also regulates the expression of PTH (show PTH Proteins) in cooperation with Gcm2

  2. Gcm2 (glial cells missing 2) are involved in the epigenetic regulation of Hes5 (show HES5 Proteins) transcription by DNA demethylation independently of DNA replication.

  3. role of Shh (show SHH Proteins) signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  4. GCM (show GCM1 Proteins) domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.

  5. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.

GCM2 Protein Profile

Protein Summary

This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.

Gene names and symbols associated with GCM2

  • glial cells missing homolog 2 (Drosophila) (GCM2)
  • glial cells missing homolog 2 (Drosophila) (gcm2)
  • glial cells missing homolog 2 (gcm2)
  • glial cells missing homolog 2 (LOC100228942)
  • glial cells missing homolog 2 (LOC100358264)
  • glial cells missing homolog 2 (Drosophila) (Gcm2)
  • gcm-2 protein
  • Gcm-rs1 protein
  • Gcm1 protein
  • Gcm1-rs2 protein
  • GCMB protein
  • hGCMb protein

Protein level used designations for GCM2

chorion-specific transcription factor GCMb , glial cells missing 2 , gcmB transcription factor , glial cell missing-like protein , transcription factor glial cells missing-2 , transcription factor Glial cells missing-2 , glial cells missing protein homolog 2 , glial cells missing homolog 2 , GCM motif protein 2 , glial cells missing homolog b , glide/gcm protein homolog , mGCMb

GENE ID SPECIES
428478 Gallus gallus
449615 Danio rerio
496398 Xenopus laevis
539454 Bos taurus
100228942 Taeniopygia guttata
100358264 Oryctolagus cuniculus
9247 Homo sapiens
107889 Mus musculus
488217 Canis lupus familiaris
291047 Rattus norvegicus
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