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induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure [RGD, Feb 2006].. Additionally we are shipping GLP1R Antibodies (137) and GLP1R Kits (16) and many more products for this protein.
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Role of cysteine 341 and arginine 348 of GLP-1 receptor in G-protein coupling.
Results suggest that pancreatic ductal adenocarcinoma (PDAC) cells or their precursor lesions do not overexpress glucagon-like peptide-1 receptor (GLP-1R) compared with non-neoplastic pancreatic cells.
The molecular dynamics simulations of wild-type and mutant GLP (show RCBTB1 Proteins)-1R.ligand complexes provided molecular insights into GLP-1R-specific recognition mechanisms for the N terminus of GLP-1 (show GCG Proteins) by residues in the 7TM pocket and explained how glucagon (show GCG Proteins)-mimicking GLP-1 (show GCG Proteins) mutants restored binding affinity for (glucagon receptor (show GCGR Proteins) -mimicking) GLP-1R mutants.
NMR-determined structure of a high-potency cyclic conformationally-constrained 11-residue analogue of GLP-1 (show GCG Proteins) was also docked into the receptor-binding site.
Lack of association of rs6923761 GLP-1 R polymorphism with weight loss.
An association was found between the rs6923761 GLP-1 receptor polymorphism and basal GLP-1 (show GCG Proteins) levels in diabetes mellitus type 2 patients.
although GLP-1R is not an independent prognostic factor in PDAC patients, it appears to have some implications for pancreatic ductal adenocarcinoma metastatic ability
Retinal GLP1R expression was similar in patients with diabetes and healthy controls.
GLP-1R rs10305420 polymorphism explained some of the inter-individual differences in response to liraglutide regarding weight loss in obese PCOS women.
168Ser (rs6923761) was nominally associated with alcohol use disorder. The 168 Ser/Ser genotype was associated with increased alcohol administration, and with higher BOLD response in the right globus pallidus.
a novel GLP1R Interacting Protein ATP6ap2 (show ATP6AP2 Proteins)
CB1 (show CNR1 Proteins) activation negatively impacts GLP-1R-mediated insulin (show INS Proteins) secretion.
These differential effects of exogenous Glp1r in nondiabetic and diabetic mice suggest that downregulation of Glp1r might be required to slow the progression of beta-cell failure under diabetic conditions.
although endogenous GLP-1R signalling contributes to increased brown adipose tissue thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 (show GCG Proteins) mimetic liraglutide in obese mice
GLP-1R is present in pancreatic acinar cells and that GLP-1 (show GCG Proteins) can regulate secretion through its receptor and cAMP signaling pathway.
GLP1R is expressed in mouse retina. GLP-1R protein abundance was independent of the presence of diabetes.
The data of this study reveal a novel role of GLP-1R in dorsal lateral septum function driving behavioral responses to cocaine.
GLP-1R agonism significantly reduced alcohol consumption in a mouse model of alcohol dependence.
these data provide novel evidence that lipotoxicity decreases the mesangial GLP-1R expression in intact cells and in vivo.
These results support a role for extra islet GLP1R in oral glucose tolerance and paracrine regulation of beta cells by islet GLP-1 (show GCG Proteins).
For the binding between 125I-liraglutide and the GLP-1 receptor on the surface of INS-1 cells, the equilibrium dissociation constant (Kd) was 128.8 +/- 30.4 nmol/L(N = 3), and the half-inhibition concentration (IC50) was 542.4 +/- 187.5 nmol/L(N = 3).
induces insulin secretion\; mediates neuroendocrine signaling of feeding behavior\; mediates cardiovascular response and increased blood pressure
glucagon-like peptide 1 receptor
, glucagon-like peptide 1 receptor-like
, GLP-1 receptor
, pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1