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Glucokinase (Hexokinase 4) (GCK) ELISA Kits

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Additionally we are shipping GCK Antibodies (118) and GCK Proteins (47) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GCK 103988 P52792
GCK 24385 P17712
GCK 2645 P35557
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Top GCK ELISA Kits at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 0.156 ng/mL 0.625-40 ng/mL Typical standard curve 96 Tests Log in to see 9 to 11 Days
$1,026.67
Details
Mouse 0.054 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$682.11
Details
Human 0.23 ng/mL 0.78-50 ng/mL 96 Tests Log in to see 9 to 11 Days
$589.47
Details
Rabbit 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 11 to 13 Days
$785.71
Details
Guinea Pig 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 11 to 13 Days
$801.43
Details
Dog 0.1 ng/mL 0.5-10 ng/mL 96 Tests Log in to see 11 to 13 Days
$801.43
Details
Chicken 3.75 ng/mL 6.25-400 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Pig 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Monkey 0.469 ng/mL 0.781-50 ng/mL   96 Tests Log in to see 8 to 9 Days
$715.00
Details
Goat
  96 Tests Log in to see 11 to 13 Days
$801.43
Details

Top referenced GCK ELISA Kits

  1. Rat (Rattus) GCK ELISA Kit for Sandwich ELISA - ABIN578035 : Godini, Ghasemi, Zahediasl: The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats. in PLoS ONE 2015 (PubMed)

More ELISA Kits for GCK Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GKRP (show GCKR ELISA Kits) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261)

  2. lncLGR facilitates the recruitment of hnRNPL (show HNRNPL ELISA Kits) to the GCK promoter and suppresses GCK transcription.

  3. Given that acetylated GKRP (show GCKR ELISA Kits) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR ELISA Kits) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR ELISA Kits) pathway, for treating T2DM and other metabolic pathologies.

  4. These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (show INS ELISA Kits) secretion through regulation of cytoplasmic Ca(2 (show CA2 ELISA Kits)+) levels.

  5. GHR (show GHR ELISA Kits) knockdown caused increased glucokinase mRNA and protein levels.

  6. results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT (show BAAT ELISA Kits) as well as liver-to-beta-cell) metabolic communication

  7. Atf3 (show ATF3 ELISA Kits)-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin (show INS ELISA Kits) resistance.

  8. Suggest heterozygous glucokinase knockout mouse as a translatable model of human type 2 diabetes.

  9. In the liver-specific glucokinase knockout mouse reduced expression of glucokinase in the liver induces diabetic cardiomyopathy.

  10. Glucokinase is regulated by the ubiquitin-proteasome system to avoid misfolding and reduced activity of the enzyme.

Human Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. The results show that p.Leu77Arg but not p.Val101Met GCK mutation is considered a pathogenic mutation associated with maturity onset diabetes of the young.

  2. GCK mutations are associated with Maturity onset diabetes of youth.

  3. glucokinase mutation is associated with Maturity-Onset Diabetes of the Young, Type 2.

  4. The number of mutations in GCK/MODY2 or even other MODY (show HNF4A ELISA Kits)-related genes is undoubtedly underestimated, as accepted criteria for performing genetic tests include family history of the pathology.

  5. Plasma ghrelin (show GHRL ELISA Kits) is higher in glucokinase-maturity onset diabetes of the young than in the common polygenic forms of diabetes.

  6. Given that acetylated GKRP (show GCKR ELISA Kits) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR ELISA Kits) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR ELISA Kits) pathway, for treating T2DM and other metabolic pathologies.

  7. The results of this study showed that mutations in the GCK gene are the leading cause of maturity-onset diabetes of the young in our population

  8. DR of any degree was not present in our GCK-MODY (show HNF4A ELISA Kits) group, while in spite of young age almost every fourth subject with HNF1A (show HNF1A ELISA Kits)-MODY (show HNF4A ELISA Kits) showed signs of this complication.

  9. Complete sequencing of the GCK gene, carried out in the patient, identified a novel mutation c.1268T>A (p.Phe423Tyr) in exon 10 of the gene GCK in heterozygosity. Further studies revealed the same mutation in her mother and maternal grandfather

  10. Thus, a glucokinase activator drug therapy may help MODY2 patients not in general, but seems to be a useful strategy for carriers of the L315H glucokinase mutation.

GCK Antigen Profile

Antigen Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Gene names and symbols associated with GCK

  • glucokinase (hexokinase 4) (GCK) antibody
  • glucokinase (GCK) antibody
  • glucokinase (glcK) antibody
  • glucokinase (Bphyt_1025) antibody
  • glucokinase (Halhy_6548) antibody
  • glucokinase (gk) antibody
  • glucokinase (hexokinase 4) (gck) antibody
  • glucokinase (Gck) antibody
  • glucokinase (LOC100341946) antibody
  • glucokinase (hexokinase 4) (Gck) antibody
  • mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2) antibody
  • AI385662 antibody
  • BA4487 antibody
  • BL44 antibody
  • FGQTL3 antibody
  • GCK antibody
  • gck-A antibody
  • GK antibody
  • GLK antibody
  • Gls006 antibody
  • glucokinase antibody
  • GLUKA antibody
  • HHF3 antibody
  • HK4 antibody
  • HKIV antibody
  • HXKP antibody
  • LGLK antibody
  • MODY2 antibody
  • Rab8ip antibody
  • RNGK2 antibody

Protein level used designations for GCK

glucokinase , hexokinase 4 , HK IV , hexokinase type IV , hexokinase-4 , hexokinase-D , HK4 , ATP:D-hexose 6-phosphotransferase , hexokinase D, pancreatic isozyme , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , MAPK/ERK kinase kinase kinase 2 , MEK kinase kinase 2 , MEKKK 2 , RAB8 interacting protein , germinal center kinase , mitogen activated protein kinase kinase kinase kinase 2 , rab8-interacting protein

GENE ID SPECIES
100051836 Equus caballus
374086 Gallus gallus
606490 Canis lupus familiaris
1087979 Bacillus anthracis str. Ames
2797963 Listeria monocytogenes serotype 4b str. F2365
3728664 Carboxydothermus hydrogenoformans Z-2901
6284349 Burkholderia phytofirmans PsJN
10590758 Haliscomenobacter hydrossis DSM 1100
100135866 Oncorhynchus mykiss
378602 Xenopus laevis
100124905 Xenopus (Silurana) tropicalis
103988 Mus musculus
24385 Rattus norvegicus
100341946 Oryctolagus cuniculus
2645 Homo sapiens
100037406 Felis catus
616576 Bos taurus
430370 Gallus gallus
100514142 Sus scrofa
100717630 Cavia porcellus
26412 Mus musculus
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