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Glucokinase (Hexokinase 4) Proteins (GCK)

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Additionally we are shipping GCK Antibodies (110) and GCK Kits (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCK 103988 P52792
GCK 24385 P17712
GCK 2645 P35557
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Top GCK Proteins at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 2 to 3 Days
$178.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$583.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Streptomyces coelicolor His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
Yeast Streptomyces lividans His tag   1 mg Log in to see 56 to 66 Days
$2,849.00
Details
Yeast Shigella flexneri His tag   1 mg Log in to see 56 to 66 Days
$2,861.83
Details
Yeast Salmonella arizonae His tag   1 mg Log in to see 56 to 66 Days
$2,861.83
Details

GCK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , ,
,

Top referenced GCK Proteins

  1. Human GCK Protein expressed in Escherichia coli (E. coli) - ABIN2003921 : Arden, Harbottle, Baltrusch, Tiedge, Agius: Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation. in Diabetes 2004 (PubMed)
    Show all 3 references for ABIN2003921

  2. Human GCK Protein expressed in Escherichia coli (E. coli) - ABIN668035 : Wilson: Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. in The Journal of experimental biology 2003 (PubMed)

More Proteins for Glucokinase (Hexokinase 4) (GCK) Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. GKRP (show GCKR Proteins) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. Given that acetylated GKRP (show GCKR Proteins) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR Proteins) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR Proteins) pathway, for treating T2DM and other metabolic pathologies.

  2. These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (show INS Proteins) secretion through regulation of cytoplasmic Ca(2 (show CA2 Proteins)+) levels.

  3. GHR (show GHR Proteins) knockdown caused increased glucokinase mRNA and protein levels.

  4. results suggest that chronic suppression of hepatic glucokinase has a small influence on intertissue (liver-to-BAT (show BAAT Proteins) as well as liver-to-beta-cell) metabolic communication

  5. Atf3 (show ATF3 Proteins)-silencing reversed ethanol-mediated Gck down-regulation and beta-cell dysfunction, followed by the amelioration of impaired glucose tolerance and insulin (show INS Proteins) resistance.

  6. Suggest heterozygous glucokinase knockout mouse as a translatable model of human type 2 diabetes.

  7. In the liver-specific glucokinase knockout mouse reduced expression of glucokinase in the liver induces diabetic cardiomyopathy.

  8. Glucokinase is regulated by the ubiquitin-proteasome system to avoid misfolding and reduced activity of the enzyme.

  9. IRS-2 (show IRS2 Proteins) signalling is important for maintaining the activity of liver glucokinase.

  10. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity

Human Glucokinase (Hexokinase 4) (GCK) interaction partners

  1. Plasma ghrelin (show GHRL Proteins) is higher in glucokinase-maturity onset diabetes of the young than in the common polygenic forms of diabetes.

  2. Given that acetylated GKRP (show GCKR Proteins) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (show GCKR Proteins) acetylation in the liver could reveal novel targets within the GK-GKRP (show GCKR Proteins) pathway, for treating T2DM and other metabolic pathologies.

  3. The results of this study showed that mutations in the GCK gene are the leading cause of maturity-onset diabetes of the young in our population

  4. DR of any degree was not present in our GCK-MODY (show HNF4A Proteins) group, while in spite of young age almost every fourth subject with HNF1A (show HNF1A Proteins)-MODY (show HNF4A Proteins) showed signs of this complication.

  5. Complete sequencing of the GCK gene, carried out in the patient, identified a novel mutation c.1268T>A (p.Phe423Tyr) in exon 10 of the gene GCK in heterozygosity. Further studies revealed the same mutation in her mother and maternal grandfather

  6. Thus, a glucokinase activator drug therapy may help MODY2 patients not in general, but seems to be a useful strategy for carriers of the L315H glucokinase mutation.

  7. This is the first report that presents a significant association of polymorphism rs2268574 in Glucokinase gene with gestational Diabetes mellitus patients.

  8. Aberrant methylation of the GCK gene body was significantly associated with the risk of essential hypertension.

  9. High levels of HbA1c were associated with an increased risk of recurrence of atrial tachyarrhythmia in patients with T2DM and PAF (show KIAA0101 Proteins) undergoing catheter ablation.

  10. analysis of allosteric activation mechanisms in monomeric human glucokinase

GCK Protein Profile

Protein Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Gene names and symbols associated with GCK

  • glucokinase (hexokinase 4) (GCK)
  • glucokinase (GCK)
  • glucokinase (glcK)
  • glucokinase (Bphyt_1025)
  • glucokinase (Halhy_6548)
  • glucokinase (gk)
  • glucokinase (hexokinase 4) (gck)
  • glucokinase (Gck)
  • glucokinase (LOC100341946)
  • glucokinase (hexokinase 4) (Gck)
  • mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2)
  • AI385662 protein
  • BA4487 protein
  • BL44 protein
  • FGQTL3 protein
  • GCK protein
  • gck-A protein
  • GK protein
  • GLK protein
  • Gls006 protein
  • glucokinase protein
  • GLUKA protein
  • HHF3 protein
  • HK4 protein
  • HKIV protein
  • HXKP protein
  • LGLK protein
  • MODY2 protein
  • Rab8ip protein
  • RNGK2 protein

Protein level used designations for GCK

glucokinase , hexokinase 4 , HK IV , hexokinase type IV , hexokinase-4 , hexokinase-D , HK4 , ATP:D-hexose 6-phosphotransferase , hexokinase D, pancreatic isozyme , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , MAPK/ERK kinase kinase kinase 2 , MEK kinase kinase 2 , MEKKK 2 , RAB8 interacting protein , germinal center kinase , mitogen activated protein kinase kinase kinase kinase 2 , rab8-interacting protein

GENE ID SPECIES
100051836 Equus caballus
374086 Gallus gallus
606490 Canis lupus familiaris
1087979 Bacillus anthracis str. Ames
2797963 Listeria monocytogenes serotype 4b str. F2365
3728664 Carboxydothermus hydrogenoformans Z-2901
6284349 Burkholderia phytofirmans PsJN
10590758 Haliscomenobacter hydrossis DSM 1100
100135866 Oncorhynchus mykiss
378602 Xenopus laevis
100124905 Xenopus (Silurana) tropicalis
103988 Mus musculus
24385 Rattus norvegicus
100341946 Oryctolagus cuniculus
2645 Homo sapiens
100037406 Felis catus
616576 Bos taurus
430370 Gallus gallus
100514142 Sus scrofa
100717630 Cavia porcellus
26412 Mus musculus
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