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GCKR encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. Additionally we are shipping GCKR Antibodies (84) and GCKR Proteins (11) and many more products for this protein.
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The GCKR rs780092 variant showed opposite-directional associations with type 2 diabetes and hypertriacylglycerolaemia in a Chinese population.
Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.
The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
Two new polymorphisms associated with gall bladder disease and obesity in women have been identified, GCKR rs1260326, and TTC39B rs686030.
We found that the PPARGC1A (show PPARGC1A ELISA Kits) and PNPLA3 (show PNPLA3 ELISA Kits) variants, but not the GCKR variant, were associated with NASH (show SAMSN1 ELISA Kits).
Disruption of the GKRP-glucokinase (show GCK ELISA Kits) complex is a promising new antidiabetic target, since it results in lower plasma glucose levels without inducing hypoglycemia[review]
this is the first evidence that n-3 LC-PUFAs may modulate the impact of the GCKR rs1260326 polymorphism on TG concentrations in adolescents. Several molecular mechanisms, in link with glucose uptake, could explain these findings
SNPs in SORT1 (show SORT1 ELISA Kits), CETP (show CETP ELISA Kits) and GCKR were individually associated with lipid level variations in Algerian population.
interaction effects between GCKR genetic variants and the dietary MUFA:SFA ratio on lipid levels
rs1260326 in GCKR significantly associates with alpha-1 antitrypsin (show SERPINA1 ELISA Kits) levels.
Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.
Germinal center kinase-related (show MAP4K5 ELISA Kits) enzyme (GCKR) facilitates both canonical and noncanonical Wnt (show WNT2 ELISA Kits) signaling in B lymphocytes.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
glucokinase regulatory protein
, glucokinase regulator
, MAPK/ERK kinase kinase kinase 5
, MEK kinase kinase 5
, MEKKK 5