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anti-Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) Antibodies

The protein encoded by GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Additionally we are shipping GNE Proteins (6) and GNE Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GNE 10020 Q9Y223
GNE 50798 Q91WG8
GNE 114711 O35826
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Top anti-GNE Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB GNE Antibody (C-term) (ABIN651511) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the GNE antibody detected GNE protein (arrow). GNE Antibody (C-term) (ABIN651511) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB GNE Antibody (N-term) (ABIN656219) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with GNE / GLCNE Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of GNE / GLCNE Antibody (N-term) in human placenta tissue lysates (35ug/lane). This demonstrates the GNE antibody detected the GNE protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Biotin FACS, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

GNE Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GNE Antibodies

  1. Human Polyclonal GNE Primary Antibody for EIA, IHC (p) - ABIN952566 : Stober, Aleo, Kuhl, Bornemann, Walter, Lochmüller, Lindner, Krause: Novel missense mutation p.A310P in the GNE gene in autosomal-recessive hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles in an Italian family. in Neuromuscular disorders : NMD 2010 (PubMed)
    Show all 2 references for ABIN952566

  2. Human Polyclonal GNE Primary Antibody for FACS, WB - ABIN651511 : Klootwijk, Savelkoul, Ciccone, Manoli, Caplen, Krasnewich, Gahl, Huizing: Allele-specific silencing of the dominant disease allele in sialuria by RNA interference. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 (PubMed)

  3. Human Polyclonal GNE Primary Antibody for IHC (p), WB - ABIN656219 : Reinke, Hinderlich: Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. in FEBS letters 2007 (PubMed)

More Antibodies against GNE Interaction Partners

Zebrafish Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. The results demonstrate a critical novel role for gne in embryonic development and particularly in myofiber development, muscle integrity and activity.

Human Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. This study confirms that c.2228T>C (p.M743T) is the most prevalent disease-causing variant in the non-Jewish Persian population, but other GNE variants can cause GNE myopathy in this population.

  2. examined the consequences of the mutated GNEM743T enzyme in myoblasts cultures, depicted by the pattern of central signaling proteins of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies), BCL2 (show BCL2 Antibodies) and ARTS/XIAP (show XIAP Antibodies) pathways

  3. Novel GNE mutations were linked to GNE myopathy in patients from mainland China.

  4. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  5. mutation in UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) affects beta1-integrin-mediated cell adhesion process in GNE mutant cells

  6. GNE myopathy is an autosomal recessive muscle disease caused by biallelic mutations in GNE, a gene encoding for a single protein with key enzymatic activities--{REVIEW}

  7. Multiple GNE mutations are associated with GNE myopathy.

  8. NCBI GenBank accession numbers for the two major isoforms hGNE1 and hGNE2 and their ENSEMBL IDs (show IDS Antibodies), as well as discussion of nomenclature changes

  9. In two Jewish Iranian unrelated families with hereditary inclusion body myopathy, 6 patients were found homozygous for the c.2135 T>C (p.M712T) mutation in exon 12 of GNE.

  10. the prevalence of GNE p.M712T and hereditary inclusion body myopathy is higher in the Sangesar population, comprised mostly of Muslim and Bahai descendants, compared with the general world population

Mouse (Murine) Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) interaction partners

  1. GNE is a master regulator of sialic acid synthesis in the vertebrates. (Review)

  2. Analysis of differential Gne transcript expression of the two splice variants, Gne1 and Gne2.

  3. GNE is strongly involved in cardiac tissue and skeletal muscle early survival and organization.

  4. Our findings suggest that GNE expression is induced when myofibers are damaged or regenerating, and that GNE plays a role in muscle regeneration.

  5. sialic acid biosynthesis is involved in proliferation and expression of GNE

  6. inactivation of the UDP-GlcNAc (show B3GNT2 Antibodies) 2-epimerase (show RENBP Antibodies) by gene targeting causes early embryonic lethality in mice, thereby emphasizing the fundamental role of this bifunctional enzyme and sialylation during development

  7. compared the amount of membrane-bound sialic acids of wildtype mice with those of heterozygous GNE-deficient mice

  8. Mutations in the Gne enzyme, which encode the rate-limiting enzyme in sialic acid biosynthesis, are causative of distal myopathies with rimmed vacuoles or hereditary inclusion body myopathy.

GNE Antigen Profile

Protein Summary

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Gene names and symbols associated with GNE

  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) antibody
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (gne) antibody
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Gne) antibody
  • 2310066H07Rik antibody
  • DMRV antibody
  • GLCNE antibody
  • GNE antibody
  • IBM2 antibody
  • MGC145505 antibody
  • NM antibody
  • Uae1 antibody
  • zgc:77657 antibody

Protein level used designations for GNE

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase , bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase-like , N-acylmannosamine kinase , UDP-GlcNAc-2-epimerase/ManAc kinase , UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase , UDP-N-acetylglucosamine-2-epimerase/N- acetylmannosamine kinase

GENE ID SPECIES
641344 Sus scrofa
393857 Danio rerio
427285 Gallus gallus
465094 Pan troglodytes
481607 Canis lupus familiaris
693525 Macaca mulatta
780185 Xenopus (Silurana) tropicalis
782201 Bos taurus
100171416 Pongo abelii
100340455 Oryctolagus cuniculus
100414213 Callithrix jacchus
100481169 Ailuropoda melanoleuca
100541275 Meleagris gallopavo
100554566 Anolis carolinensis
100589824 Nomascus leucogenys
10020 Homo sapiens
50798 Mus musculus
114711 Rattus norvegicus
100689450 Cricetulus griseus
Selected quality suppliers for anti-GNE (GNE) Antibodies
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