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anti-Glucosidase, beta (Bile Acid) 2 (GBA2) Antibodies

GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Additionally we are shipping GBA2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GBA2 230101 Q69ZF3
GBA2 298399  
GBA2 57704 Q9HCG7
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Top anti-GBA2 Antibodies at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of Beta-glucosidase 2 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of Beta-glucosidase 2 expression in A431 (A), HeLa (B), A549 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Biotin IHC (p), WB   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$379.50
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$379.50
Details

GBA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against GBA2 Interaction Partners

Zebrafish Glucosidase, beta (Bile Acid) 2 (GBA2) interaction partners

  1. GBA2 loss of function led to abnormal motor behavior and axonal shortening/branching of motoneurons.

Mouse (Murine) Glucosidase, beta (Bile Acid) 2 (GBA2) interaction partners

  1. GBA2 is particularly abundant in Purkinje cells (PCs), one of the most affected neuronal populations in NPC (show NPC1 Antibodies) disease.

  2. glucosylceramide accumulation in GBA2 knockout-mice alters cytoskeletal dynamics due to a more ordered lipid organization in the plasma membrane. Similar cytoskeletal defects were observed in male germ and Sertoli cells from GBA2 knockout-mice.

  3. the deletion of Gba2 significantly rescues the type 1 Gaucher disease clinical phenotype.

  4. redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butyldeoxygalactonojirimycin.

  5. GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of glucosylceramide-dependent signaling.

  6. The repression of IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signalling pathway seems to be one of the mechanisms for the delay of liver regeneration in GBA2-deficient mice.

  7. GBA1 (show GBA Antibodies) and GBA2 activities had characteristic differences between the studied fibroblast, liver and brain samples.

  8. The coiled-coil structure of LIMP-2 is required for its interaction wit (show SCARB2 Antibodies)h beta-glucocerebrosidase.

  9. L-type calcium channel blockers have the ex vivo effects of increasing GCase (show GBA Antibodies) activity and protein in mouse fibroblasts

  10. GBA2 is a glucosylceramidase (show GBA Antibodies) whose loss causes accumulation of glycolipids and an endoplasmic reticulum storage disease

Human Glucosidase, beta (Bile Acid) 2 (GBA2) interaction partners

  1. Spastic paraplegia/cerebellar ataxia (show USP14 Antibodies) patients have a severe deficit in GBA2 activity, because the GBA2 mutants are intrinsically inactive and/or reduced in amount.

  2. The GBA2 gene shows a low mutation frequency in a general population of complicated hereditary spastic paraparesis

  3. Whole-exome and targeted sequencing have defined the genetic basis of dizziness including new genes causing ataxia (show USP14 Antibodies): GBA2, TGM6 (show TGM5 Antibodies), ANO10 (show ANO10 Antibodies) and SYT14 (show SYT14 Antibodies)

  4. We hereby report a novel GBA2 mutation associated with spastic ataxia (show USP14 Antibodies) and suggest that GBA2 mutations may be a relatively frequent cause of autosomal recessive cerebellar ataxias.

  5. observations make GBA2 a likely candidate to be involved in Gaucher disease etiology.

  6. redefine GBA2 activity as the beta-glucosidase that is sensitive to inhibition by N-butyldeoxygalactonojirimycin.

  7. GBA2 loss of function led to abnormal motor behavior and axonal shortening/branching of motoneurons.

  8. This study suggests GBA2 mutations are a cause of recessive spastic ataxia (show USP14 Antibodies) and responsible for a form of glucosylceramide storage disease in humans.

  9. GBA2 is localized at the ER and Golgi, which puts GBA2 in a key position for a lysosome-independent route of glucosylceramide-dependent signaling.

  10. GBA2 is down-regulated in melanoma; inducible expression of GBA2 affects endogenous sphingolipid metabolism by promoting glucosylceramide degradation (decrease by 78%) and ceramide generation.

GBA2 Antigen Profile

Protein Summary

This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.

Gene names and symbols associated with GBA2

  • glucosidase, beta (bile acid) 2 (GBA2) antibody
  • glucosidase, beta (bile acid) 2 (gba2) antibody
  • glucosidase beta 2 (Gba2) antibody
  • F630034E04 antibody
  • SPG46 antibody
  • TLN1 antibody

Protein level used designations for GBA2

bile acid beta-glucosidase , talin 1 , glucosidase, beta (bile acid) 2 , non-lysosomal glucosylceramidase-like , NLGase , beta-glucocerebrosidase 2 , beta-glucosidase 2 , bile acid , glucosylceramidase 2 , non-lysosomal glucosylceramidase

GENE ID SPECIES
465082 Pan troglodytes
559240 Danio rerio
696062 Macaca mulatta
100145361 Xenopus (Silurana) tropicalis
100438148 Pongo abelii
100476888 Ailuropoda melanoleuca
230101 Mus musculus
298399 Rattus norvegicus
57704 Homo sapiens
100859407 Gallus gallus
474760 Canis lupus familiaris
100155655 Sus scrofa
100139170 Bos taurus
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