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GUSB encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. Additionally we are shipping Glucuronidase beta Kits (40) and Glucuronidase beta Proteins (12) and many more products for this protein.
Showing 10 out of 119 products:
Human Polyclonal Glucuronidase beta Primary Antibody for EIA, FACS - ABIN950654
Tomatsu, Montaño, Dung, Grubb, Sly: Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome). in Human mutation 2009
Show all 2 references for ABIN950654
Chicken Polyclonal Glucuronidase beta Primary Antibody for IHC, WB - ABIN2781774
Urayama, Grubb, Sly, Banks: Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. in Proceedings of the National Academy of Sciences of the United States of America 2004
Human Polyclonal Glucuronidase beta Primary Antibody for ELISA, WB - ABIN1451070
Hillier, Fulton, Fulton, Graves, Pepin, Wagner-McPherson, Layman, Maas, Jaeger, Walker, Wylie, Sekhon, Becker, OLaughlin, Schaller, Fewell, Delehaunty, Miner, Nash, Cordes, Du, Sun, Edwards et al.: The DNA sequence of human chromosome 7. ... in Nature 2003
The aim of this study was to compare the levels of electrolytes, inorganic phosphatase, and alkaline phosphatease, acid phosphatase, and beta-glucuronidase.
the efficacy of a helper-dependent (HD) canine adenovirus (CAV-2 (show CAV2 Antibodies)) vector harboring a human GUSB expression cassette (HD-RIGIE) in the MPS VII (show TH Antibodies) dog brain was tested
This assessment demonstrated that although butyrate dramatically increased beta-glucuronidase production in bioreactors, it adversely impacted the mannose-6-phosphorylation of this lysosomal storage diseasestherapeutic enzyme
expression of CES2, UGTA1A1, and GUSB varies in colorectal pathology tissues and that the expression of CES2 is somewhat related to tumor staging.
GUSB and ATP2B4 (show ATP2B4 Antibodies) have been validated as a reliable gene combination for Cystic Fibrosis Transmembrane Conductance Regulator (show CFTR Antibodies) gene qPCR data normalization.
Liver disease affects the expression of common HKGs; beta-glucuronidase and splicing factor arginine/serine-rich 4 (show SRSF4 Antibodies) are the most stable HKGs for studies of gene expression in HCV-infected human liver.
beta-glucuronidase mutations are associated with mucopolysaccharidosis type VII (show TH Antibodies)
Recombinant adeno (show ADORA2A Antibodies)-associated virus encoding human GUSB injected into the vitreous humor of young adult MPS VII (show TH Antibodies) mice increased GUSB activity and reduced lysosomal distension in regions of the thalamus and tectum
beta glucuronidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing invasion of synovial cells.
Over-expression of beta-glucuronidase was related to the degree of cancer differentiation, but not to lymph node metastasis.
These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor (show IGF2R Antibodies).
beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 (show MMP9 Antibodies) Secretion in Response to Inflammatory Stimuli
GUSB modulates arthritis pathogenesis by preventing accumulation of proinflammatory glycosaminoglycans within inflamed joint tissue.
The Gus plays a role in liver retinoid metabolism.
Missense mutations and models of murine mucopolysaccharidosis type VII (show TH Antibodies) produced by targeted mutagenesis
data indicate the expression of beta-glucuronidase coordinated with testosterone level in male CBA mice but not C57BL/6 mice
Lysosome storage in the mucopoysaccharidosis type VII (show TH Antibodies) brain was corrected by injection of an HSV-1 genetic vector and expression of Gusb was assayed. genetic vector
AnxA6 (show ANXA6 Antibodies) is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
, Beta-glucuronidase (gusB)
, adipose storage deficiency