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Glutamate Decarboxylase 1 (Brain, 67kDa) Proteins (GAD1)

GAD1 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Additionally we are shipping GAD Antibodies (167) and GAD Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GAD1 14415 P48318
GAD1 24379 P18088
GAD1 2571 Q99259
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Top GAD Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$966.00
Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,707.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GAD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , , ,
,

More Proteins for Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaction Partners

Mouse (Murine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. Gad1 knockdown mice have pronounced sensorimotor gating deficits, increased novelty-seeking and reduced fear extinction

  2. The neuronal marker UCH-L1 (show UCHL1 Proteins) is induced in, and specifically augments the oncogene (show RAB1A Proteins)-induced transformation of, germinal center B cells.

  3. Glutamate decarboxylase (show GLUL Proteins) expression may be a reliable proxy of altered GABAergic transmission.

  4. Activity deprivation due to TTX preferentially down-regulated GAD67. BDNF (show BDNF Proteins)-induced increase in the GAD67 protein was markedly lower than that of GAD65 (show GAD2 Proteins), indicating that BDNF (show BDNF Proteins) differentially regulates activity-dependent gene expression of the 2 isoforms.

  5. The results of this study indicated that the mice heterozygous for GAD67 deficiency primarily in PV neurons share several neurochemical and behavioral abnormalities with schizophrenia.

  6. Data demonstrate that GAD67 levels directly influence synaptic inhibition.

  7. The GAD65 (show GAD2 Proteins)-independent mechanism for targeting of GAD67 to synaptic vesicles in neurons is not functional in islet beta-cells.

  8. Pharmacological inhibition of UCHL1 (show UCHL1 Proteins) exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Proteins). Thus, pharmacological inhibition of UCHL1 (show UCHL1 Proteins) is not a viable therapeutic target for SMA (show SMN1 Proteins).

  9. Results indicate the significant contribution of not only GAD65, GAD67 and VGAT-mediated GABAergic but also glycinergic transmissions to both palate and abdominal wall formations

  10. These findings provide original evidence that striatal Gad67 expression is involved in the modulation of learning and social behavior.

Arabidopsis thaliana Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM (show CALM Proteins) lobes role in interactions between CaM (show CALM Proteins) and plant GAD.

  2. Insertion mutants of GAD1 revealed that GABA levels in roots were drastically reduced compared with those in the wild type.

  3. Calmodulin (show CALM Proteins) activates Gad1 in a unique way by relieving two C-terminal autoinhibition domains of adjacent active sites, forming a 393 kDa Gad1-calmodulin (show CALM Proteins) complex with an unusual 1:3 stoichiometry.

Human Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. This study showed that in female groups, the expression of GABRA5 (show GABRA5 Proteins) was generally higher in schizophrenia cases compared to the control.

  2. GAD autoantibodies were associated with risk of developing type 1 diabetes.

  3. Conversion of GAD autoantibody is associated with patients with presumed type 2 diabetes.

  4. The GAD65 (show GAD2 Proteins)-independent mechanism for targeting of GAD67 to synaptic vesicles in neurons is not functional in islet beta-cells.

  5. Gene ransfer of GAD67 by herpes simplex virus vectors prevents HIV gp120 (show ITIH4 Proteins)/ddC (show DDC Proteins)-induced neuropathic pain.

  6. Phosphate-activated glutaminase (show GLS2 Proteins) and GAD65 (show GAD2 Proteins)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls

  7. results statistically show that a reduction in GAD1 and SCL1A2 expression in the dorsolateral prefrontal cortex in subjects with major depressive disorder is related to a possible attenuated RAF (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway

  8. CNR1 (show CNR1 Proteins), GAD1 and BDNF (show BDNF Proteins) polymorphisms are associated with male heroin dependence in the Dai (show ZBP1 Proteins) population in China.

  9. The decreased amount of GAD65 (show GAD2 Proteins) and GAD67 suggests the decreased synthesis of neurotransmitter and basic GABA pools that indicates insufficient functioning of the GABA system in the cerebellar cortex of Alzheimer's disease patients.

  10. Deficient Zif268 (show EGR1 Proteins) mRNA expression may contribute to lower cortical GAD67 levels in schizophrenia, suggesting altered cortical GABA synthesis and impaired cognition in schizophrenia.

Cow (Bovine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. These results suggest that the GAD1 gene is a strong candidate gene that affects growth traits in cattle.

Zebrafish Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon

  2. High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium

  3. the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations

GAD (GAD1) Protein Profile

Protein Summary

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Gene names and symbols associated with GAD1

  • glutamate decarboxylase 1 (brain, 67kDa), gene 1 (gad1.1)
  • glutamate decarboxylase 1 (brain, 67kDa) (GAD1)
  • glutamate decarboxylase 1 (AOR_1_946174)
  • glutamate decarboxylase 1 (AOR_1_562034)
  • glutamate decarboxylase 1 (Gad1)
  • glutamate decarboxylase 1 (GAD)
  • glutamate decarboxylase 1b (gad1b)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • AO090005000539 protein
  • AO090103000342 protein
  • AW822034 protein
  • C88048 protein
  • CPSQ1 protein
  • EP10 protein
  • gad protein
  • Gad-1 protein
  • GAD-67 protein
  • GAD1 protein
  • gad1-A protein
  • GAD2 protein
  • GAD25 protein
  • GAD44 protein
  • Gad67 protein
  • glutamate decarboxylase protein
  • GLUTAMATE DECARBOXYLASE 1 protein
  • MKP11.30 protein
  • MKP11_30 protein
  • PGP9.5 protein
  • PGP 9.5 protein
  • R75593 protein
  • SCP protein
  • UCH-L1 protein
  • UCHL-1 protein

Protein level used designations for GAD1

glutamate decarboxylase 1 , glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamic acid decarboxylase 65-like protein , 67 kDa glutamic acid decarboxylase , GAD-67 , GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE) , glutamate decarboxylase 67 kDa isoform , glutamic acid decarboxylase 1 , Glutamate decarboxylase 1 (brain) , glutamate decarboxylase 1 variant GAD67NT , glutamic acid decarboxylase , glutamate decarboxylase 67 , glutamate decarboxylase, 67 kDa isoform , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin thioesterase L1

GENE ID SPECIES
378551 Xenopus laevis
778442 Taeniopygia guttata
778447 Taeniopygia guttata
5989537 Aspergillus oryzae RIB40
5999037 Aspergillus oryzae RIB40
100173252 Pongo abelii
14415 Mus musculus
24379 Rattus norvegicus
831599 Arabidopsis thaliana
2571 Homo sapiens
493699 Felis catus
478794 Canis lupus familiaris
396928 Sus scrofa
517552 Bos taurus
395743 Gallus gallus
468557 Pan troglodytes
378441 Danio rerio
22223 Mus musculus
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