anti-Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Antibodies

GAD1 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Additionally we are shipping GAD Kits (34) and GAD Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GAD1 14415 P48318
GAD1 24379 P18088
GAD1 2571 Q99259
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Top anti-GAD Antibodies at antibodies-online.com

Showing 10 out of 188 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-GAD1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human Placenta WB Suggested Anti-GAD1 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control: Human Placenta 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB GAD1 Antibody (C-term) (ABIN655175) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the GAD1 antibody detected the GAD1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN334405 (1µg/ml) staining of Mouse Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Chicken Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry: GAD1/GAD67 Antibody [NBP1-02161] - Immunohistochemical staining of mouse hippocampus (2% paraformaldehyde-fixation followed by embedding in paraffin blocks, following standard methods) using NBP1-02161 at a dilution of 1:1000. Red cells represent GAD-expressing inhibitory satellite cells found within the molecular layer of the dentate gyrus. 0.5 mL Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated WB Anti- GAD67 Picoband antibody, Western blotting All lanes: Anti GAD67  at 0.5ug/ml WB: Recombinant Human GAD67 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Rat Mouse Un-conjugated ICC, IP Immunolabeling of cultured hippocampus neurons (dilution 1 : 500). 100 μg Log in to see 5 to 6 Days
$444.68
Details
Mouse Goat Un-conjugated ELISA, WB Western Blot: GAD1/GAD67 Antibody [NBP2-27555] - NBP2-27555 (1ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Goat Un-conjugated ELISA, ICC, IF, WB Western Blot: GAD1/GAD67 Antibody [NBP1-06989] - Staining of Human Brain (Cerebellum) 35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details

GAD1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GAD Antibodies

  1. Rat (Rattus) Polyclonal GAD Primary Antibody for WB - ABIN1574123 : Ketzef, Kahn, Weissberg, Becker, Friedman, Gitler: Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. in Neuroscience 2011 (PubMed)
    Show all 2 Pubmed References

  2. Mouse (Murine) Polyclonal GAD Primary Antibody for ELISA, WB - ABIN4313131 : Wang, Wang, Ferris, Salit, Strulovici-Barel, Hackett, Crystal: Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium. in Respiratory research 2010 (PubMed)

  3. Human Monoclonal GAD Primary Antibody for ICC, IF - ABIN4313129 : Agca, Houen, Trier: Characterization of continuous B-cell epitopes in the N-terminus of glutamate decarboxylase67 using monoclonal antibodies. in Journal of peptide science : an official publication of the European Peptide Society 2014 (PubMed)

  4. Rat (Rattus) Monoclonal GAD Primary Antibody for ICC, IP - ABIN1742414 : Mikhaylova, Karpova, Bär, Bethge, YuanXiang, Chen, Zuschratter, Behnisch, Kreutz: Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain. in Brain structure & function 2014 (PubMed)

  5. Human Polyclonal GAD Primary Antibody for ICC, IHC - ABIN1742416 : Heinrich, Blum, Gascón, Masserdotti, Tripathi, Sánchez, Tiedt, Schroeder, Götz, Berninger: Directing astroglia from the cerebral cortex into subtype specific functional neurons. in PLoS biology 2010 (PubMed)

  6. Human Polyclonal GAD Primary Antibody for ICC, WB - ABIN1742415 : Beske, Scheeler, Adler, McNutt: Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing. in Frontiers in cellular neuroscience 2015 (PubMed)

  7. Human Polyclonal GAD Primary Antibody for ELISA, ICC - ABIN451637 : Mouton-Liger, Sahún, Collin, Lopes Pereira, Masini, Thomas, Paly, Luilier, Même, Jouhault, Bennaï, Beloeil, Bizot, Hérault, Dierssen, Créau: Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome. in Neurobiology of disease 2014 (PubMed)

  8. Human Polyclonal GAD Primary Antibody for ICC, IF - ABIN314830 : Valladolid-Acebes, Merino, Principato, Fole, Barbas, Lorenzo, García, Del Olmo, Ruiz-Gayo, Cano: High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. in American journal of physiology. Endocrinology and metabolism 2012 (PubMed)

More Antibodies against GAD Interaction Partners

Mouse (Murine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. The UCHL1 (show UCHL1 Antibodies) may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation.

  2. GABA is the major inhibitory neurotransmitter in the brain. We show that Dlx1/Dlx2 homeobox (show PRRX1 Antibodies) genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate (show GRIN1 Antibodies) to GABA.

  3. our study provides novel insights into the mechanisms of UCH-L1 (show UCHL1 Antibodies)-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB (show NTRK2 Antibodies)

  4. These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.

  5. Study describes in detail a population of choline acetyltransferase immunoreactive /glutamate decarboxylase 67 neurons predominantly ventral to the central canal of the cervical, thoracic and lumbar spinal cord of adult and juvenile mice. These cells potentially correspond to a sub-population of the cholinergic central canal cluster cells which may play a unique role in controlling spinal cord circuitry.

  6. This study demonstrated that Alterations in hypoglossal motor neurons due to GAD67 deficiency in mice.

  7. Treadmill running prevented partial sciatic nerve ligation-induced reductions in GAD65 (show GAD2 Antibodies)/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn.

  8. Effects of Ubiquitin C-Terminal Hydrolase (show UCHL1 Antibodies) L1 (UCH-L1 (show UCHL1 Antibodies)) inhibition on sperm incorporation and cortical tension in mouse eggs.

  9. Gad1 knockdown mice have pronounced sensorimotor gating deficits, increased novelty-seeking and reduced fear extinction

  10. The neuronal marker UCH-L1 (show UCHL1 Antibodies) is induced in, and specifically augments the oncogene (show RAB1A Antibodies)-induced transformation of, germinal center B cells.

Arabidopsis thaliana Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM (show CALM Antibodies) lobes role in interactions between CaM (show CALM Antibodies) and plant GAD.

  2. Insertion mutants of GAD1 revealed that GABA levels in roots were drastically reduced compared with those in the wild type.

  3. Calmodulin (show CALM Antibodies) activates Gad1 in a unique way by relieving two C-terminal autoinhibition domains of adjacent active sites, forming a 393 kDa Gad1-calmodulin (show CALM Antibodies) complex with an unusual 1:3 stoichiometry.

Human Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. Results show how epigenetic changes in GAD1 expression alter local glutamate (show GRIN1 Antibodies) metabolism in the brain metastatic microenvironment, contributing to a metabolic adaption that facilitates metastasis outgrowth in that setting.

  2. We investigate the possible influence of GAD1 SNPs rs3749034 and rs11542313 on ADHD susceptibility. The C allele of rs11542313 was significantly overtransmitted from parents to ADHD probands. Hyperactive/impulsive score was higher in rs3749034G allele and rs11542313C allele carriers. GAD1 haplotypes were associated with higher hyperactive/impulsive scores in ADHD youths. GAD1 gene is associated with ADHD susceptibility.

  3. GAD1 is reactivated by DNA methylation (show HELLS Antibodies), which provided a model for DNA methylation (show HELLS Antibodies) and the active orchestration of oncogenic gene expression by CTCF (show CTCF Antibodies) in cancer cells.

  4. There was no difference in GAD25 and GAD67 gene expression level, and GAD25/GAD67 ratio between patients with first episode psychosis and healthy controls

  5. Genetic variability in GAD1 and GAD2 (show GAD2 Antibodies) contributes to the risk of methamphetamine dependence in the Thai population.

  6. Reduced GAD67 expression in PV neurons is not an upstream cause of the lower levels of GABA-associated transcripts, or of the characteristic behaviors, in schizophrenia.

  7. Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Here, we used recombinant herpes simplex virus (HSV-1) vectors that encode gad1 gene to evaluate the therapeutic potential of GAD67 in peripheral HIV gp120 (show ITIH4 Antibodies)-induced neuropathic pain

  8. This study showed that in female groups, the expression of GABRA5 (show GABRA5 Antibodies) was generally higher in schizophrenia cases compared to the control.

  9. GAD autoantibodies were associated with risk of developing type 1 diabetes.

  10. Conversion of GAD autoantibody is associated with patients with presumed type 2 diabetes.

Cow (Bovine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. These results suggest that the GAD1 gene is a strong candidate gene that affects growth traits in cattle.

Zebrafish Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) interaction partners

  1. relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon

  2. High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium

  3. the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations

GAD (GAD1) Antigen Profile

Protein Summary

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Gene names and symbols associated with GAD1

  • glutamate decarboxylase 1 (brain, 67kDa), gene 1 (gad1.1) antibody
  • glutamate decarboxylase 1 (brain, 67kDa) (GAD1) antibody
  • glutamate decarboxylase 1 (AOR_1_946174) antibody
  • glutamate decarboxylase 1 (AOR_1_562034) antibody
  • glutamate decarboxylase 1 (Gad1) antibody
  • glutamate decarboxylase 1 (GAD) antibody
  • glutamate decarboxylase 1b (gad1b) antibody
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1) antibody
  • AO090005000539 antibody
  • AO090103000342 antibody
  • AW822034 antibody
  • C88048 antibody
  • CPSQ1 antibody
  • EP10 antibody
  • gad antibody
  • Gad-1 antibody
  • GAD-67 antibody
  • GAD1 antibody
  • gad1-A antibody
  • GAD2 antibody
  • GAD25 antibody
  • GAD44 antibody
  • Gad67 antibody
  • glutamate decarboxylase antibody
  • GLUTAMATE DECARBOXYLASE 1 antibody
  • MKP11.30 antibody
  • MKP11_30 antibody
  • PGP9.5 antibody
  • PGP 9.5 antibody
  • R75593 antibody
  • SCP antibody
  • UCH-L1 antibody
  • UCHL-1 antibody

Protein level used designations for GAD1

glutamate decarboxylase 1 , glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamic acid decarboxylase 65-like protein , 67 kDa glutamic acid decarboxylase , GAD-67 , GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE) , glutamate decarboxylase 67 kDa isoform , glutamic acid decarboxylase 1 , Glutamate decarboxylase 1 (brain) , glutamate decarboxylase 1 variant GAD67NT , glutamic acid decarboxylase , glutamate decarboxylase 67 , glutamate decarboxylase, 67 kDa isoform , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin thioesterase L1

GENE ID SPECIES
378551 Xenopus laevis
778442 Taeniopygia guttata
778447 Taeniopygia guttata
5989537 Aspergillus oryzae RIB40
5999037 Aspergillus oryzae RIB40
100173252 Pongo abelii
14415 Mus musculus
24379 Rattus norvegicus
831599 Arabidopsis thaliana
2571 Homo sapiens
493699 Felis catus
478794 Canis lupus familiaris
396928 Sus scrofa
517552 Bos taurus
395743 Gallus gallus
468557 Pan troglodytes
378441 Danio rerio
22223 Mus musculus
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