You are viewing an incomplete version of our website. Please click to reload the website as full version.

Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) Proteins (GAD2)

GAD2 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Additionally we are shipping GAD65 Antibodies (220) and GAD65 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GAD2 24380 Q05683
GAD2 2572 Q05329
GAD2 14417 P48320
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top GAD65 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Mouse His tag,GST tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$627.00
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$3,399.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,S tag   100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$794.65
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,046.42
Details

GAD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine) ,
,

Top referenced GAD65 Proteins

  1. Mouse (Murine) GAD65 Protein expressed in Baculovirus infected Insect Cells - ABIN2008111 : Swarbrick, Waldenmaier, Pennacchio, Lind, Cavazos, Geller, Merriman, Ustaszewska, Malloy, Scherag, Hsueh, Rief, Mauvais-Jarvis, Pullinger, Kane, Dent, McPherson, Kwok, Hinney, Hebebrand, Vaisse: Lack of support for the association between GAD2 polymorphisms and severe human obesity. in PLoS biology 2005 (PubMed)
    Show all 2 references for ABIN2008111

  2. Human GAD65 Protein expressed in Wheat germ - ABIN1354671 : Grupillo, Gualtierotti, He, Sisino, Bottino, Rudert, Trucco, Fan: Essential roles of insulin expression in Aire+ tolerogenic dendritic cells in maintaining peripheral self-tolerance of islet ?-cells. in Cellular immunology 2012 (PubMed)
    Show all 2 references for ABIN1354671

More Proteins for Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) Interaction Partners

Rhesus Monkey Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) interaction partners

  1. Results describe the gross distribution patterns of GAD65 in human and rhesus monkey thalami and show that they are nearly identical.

Zebrafish Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) interaction partners

  1. GAD65 mRNA was found in the periaqueductal gray.

Human Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) interaction partners

  1. UV exposed hydrogen peroxide produces hydroxyl radical that may cause protein damage (GAD-65) to the extent of generating neo-epitopes on the molecule, making it immunogenic.

  2. we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de-carboxylase 2 (GAD2) 5'-untranslated region

  3. GAD (show GAD1 Proteins) autoantibodies were associated with risk of developing type 1 diabetes.

  4. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 (show PTPRN Proteins) antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation.

  5. Plasma GAD65 qualifies as a marker for early beta-cell loss after intraportal transplantation.

  6. Cohort study shows that mean GAD65 mRNA levels in the prefrontal cortex area 9 are not altered in subjects with schizophrenia but are lower in subjects with schizoaffective disorder

  7. Data suggest that women with gestational diabetes who develop autoantibodies against GAD2 (glutamate decarboxylase 2) exhibit higher blood glucose levels, insulin (show INS Proteins) resistance, and impaired insulin (show INS Proteins) secretion from beta cells in the postpartum period.

  8. Phosphate-activated glutaminase (show GLS2 Proteins) and GAD65/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls

  9. GAD2 SNPs significantly associate with early-onset obsessive compulsive disorder.

  10. The decreased amount of GAD65 and GAD67 (show GAD1 Proteins) suggests the decreased synthesis of neurotransmitter and basic GABA pools that indicates insufficient functioning of the GABA system in the cerebellar cortex of Alzheimer's disease patients.

Mouse (Murine) Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2) interaction partners

  1. Increased activity due to bicuculline preferentially up-regulated GAD65. This was reduced by AP5, a selective blocker of Ca2 (show CA2 Proteins)+-permeable ion channels and NMDA-Rs, and by U0126, KN93, and K252a, affecting BDNF (show BDNF Proteins) pathways.

  2. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2 (show PTPRN Proteins), IA-2beta (show PTPRN2 Proteins), and GAD65 enzyme.

  3. Results indicate the significant contribution of not only GAD65, GAD67 and VGAT-mediated GABAergic but also glycinergic transmissions to both palate and abdominal wall formations

  4. Analysis of GAD65/67 single and double knock-out embryos revealed that the two GADs play complementary (inhibitory) roles in GnRH migration ultimately modulating the speed and/or direction of GnRH migration.

  5. Results show that GAD65 is required for efficient GABAergic synaptic transmission and plasticity, and for maintaining extracellular GABA at (show ABAT Proteins) a level needed for associative plasticity at cortical inputs in the lateral amygdala

  6. Menin (show MEN1 Proteins) regulates spinal glutamate (show GRIN1 Proteins)-GABA balance through GAD65 contributing to neuropathic pain.

  7. Our data suggest a role of GAD65-mediated GABA synthesis in the encoding of circadian information to fear memory

  8. Autoimmunity to GAD65 may play a role in the development of Stiff person syndrome.

  9. Prenatal and postnatal maternal effects influence GAD65 and GAD67 (show GAD1 Proteins) gene expression depending on the age of the offspring.

  10. These findings indicate novel, differential roles for GluN2A (show GRIN2A Proteins), B and D receptors and for GAD65-mediated GABA in the regulation of individual topographies of orofacial movement

GAD65 (GAD2) Protein Profile

Protein Summary

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with GAD2

  • glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2)
  • glutamate decarboxylase 2 (GAD2)
  • glutamate decarboxylase 2 (PTRG_06148)
  • glutamate decarboxylase 2 (ARALYDRAFT_894224)
  • glutamate decarboxylase 2 (Gad2)
  • glutamate decarboxylase 2 (LOC100344727)
  • glutamate decarboxylase 2 (gad2)
  • glutamic acid decarboxylase 2 (Gad2)
  • 6330404F12Rik protein
  • F12P19.12 protein
  • F12P19_12 protein
  • GAD(65) protein
  • Gad-2 protein
  • gad65 protein
  • glutamate decarboxylase 2 protein
  • zgc:112198 protein

Protein level used designations for GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamate decarboxylase 2 , glutamic acid decarboxylase , 65 kDa glutamic acid decarboxylase , GAD-65 , Glutamate decarboxylase 2 (islet) , glutamate decarboxylase 65 kDa isoform , glutamic acid decarboxylase 2 , glutamic acid decarboxylase 65 , Glutamate decarboxylase-2 (pancreas)

GENE ID SPECIES
466026 Pan troglodytes
512459 Bos taurus
613029 Macaca mulatta
4836947 Scheffersomyces stipitis CBS 6054
6344405 Pyrenophora tritici-repentis Pt-1C-BFP
9324534 Arabidopsis lyrata subsp. lyrata
24380 Rattus norvegicus
100344727 Oryctolagus cuniculus
842908 Arabidopsis thaliana
550403 Danio rerio
2572 Homo sapiens
487107 Canis lupus familiaris
395395 Gallus gallus
396929 Sus scrofa
14417 Mus musculus
Selected quality suppliers for GAD65 Proteins (GAD2)
Did you look for something else?