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GAD2 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Additionally we are shipping GAD65 Kits (28) and GAD65 Proteins (18) and many more products for this protein.
Showing 10 out of 215 products:
Human Monoclonal GAD65 Primary Antibody for IHC (fro), IP - ABIN967657
Bu, Erlander, Hitz, Tillakaratne, Kaufman, Wagner-McPherson, Evans, Tobin: Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 7 references for ABIN967657
Rat (Rattus) Monoclonal GAD65 Primary Antibody for ICC, IP - ABIN1742417
Coley, Ruffin, Moss, Hopfer, Boron: Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons. in Neuroscience 2013
Show all 3 references for ABIN1742417
Mouse (Murine) Monoclonal GAD65 Primary Antibody for FACS, IP - ABIN1042632
Steed, Gilliam, Harris, Lernmark, Hampe: Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein. in Journal of immunological methods 2008
Show all 3 references for ABIN1042632
Human Polyclonal GAD65 Primary Antibody for EIA, IF - ABIN952422
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 2 references for ABIN952422
Human Polyclonal GAD65 Primary Antibody for ICC, IF - ABIN4313137
Grigoryan, Segal: Prenatal stress affects network properties of rat hippocampal neurons. in Biological psychiatry 2013
Show all 2 references for ABIN4313137
Human Polyclonal GAD65 Primary Antibody for ELISA, WB - ABIN185388
Meyre, Boutin, Tounian, Deweirder, Aout, Jouret, Heude, Weill, Tauber, Tounian, Froguel: Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? in The Journal of clinical endocrinology and metabolism 2005
Results describe the gross distribution patterns of GAD65 in human and rhesus monkey thalami and show that they are nearly identical.
GAD65 mRNA was found in the periaqueductal gray.
Study propose that aberrant accumulation of immunogenic GAD65 in Golgi membranes facilitates inappropriate presentation to the immune system after release from stressed and/or damaged beta-cells, triggering autoimmunity.
UV exposed hydrogen peroxide produces hydroxyl radical that may cause protein damage (GAD-65) to the extent of generating neo-epitopes on the molecule, making it immunogenic.
we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of the glutamic acid de-carboxylase 2 (GAD2) 5'-untranslated region
GAD (show GAD1 Antibodies) autoantibodies were associated with risk of developing type 1 diabetes.
Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 (show PTPRN Antibodies) antibodies versus those patients with negative auto-antibodies and GAD65+ auto-antibodies after simultaneous pancreas kidney transplantation.
Plasma GAD65 qualifies as a marker for early beta-cell loss after intraportal transplantation.
Cohort study shows that mean GAD65 mRNA levels in the prefrontal cortex area 9 are not altered in subjects with schizophrenia but are lower in subjects with schizoaffective disorder
Data suggest that women with gestational diabetes who develop autoantibodies against GAD2 (glutamate decarboxylase 2) exhibit higher blood glucose levels, insulin (show INS Antibodies) resistance, and impaired insulin (show INS Antibodies) secretion from beta cells in the postpartum period.
Phosphate-activated glutaminase (show GLS2 Antibodies) and GAD65/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls
GAD2 SNPs significantly associate with early-onset obsessive compulsive disorder.
Treadmill running prevented partial sciatic nerve ligation-induced reductions in GAD65/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn.
Increased activity due to bicuculline preferentially up-regulated GAD65. This was reduced by AP5, a selective blocker of Ca2 (show CA2 Antibodies)+-permeable ion channels and NMDA-Rs, and by U0126, KN93, and K252a, affecting BDNF (show BDNF Antibodies) pathways.
Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2 (show PTPRN Antibodies), IA-2beta (show PTPRN2 Antibodies), and GAD65 enzyme.
Results indicate the significant contribution of not only GAD65, GAD67 (show GAD1 Antibodies) and VGAT (show SLC32A1 Antibodies)-mediated GABAergic but also glycinergic transmissions to both palate and abdominal wall formations
Analysis of GAD65/67 single and double knock-out embryos revealed that the two GADs play complementary (inhibitory) roles in GnRH migration ultimately modulating the speed and/or direction of GnRH migration.
Results show that GAD65 is required for efficient GABAergic synaptic transmission and plasticity, and for maintaining extracellular GABA at (show ABAT Antibodies) a level needed for associative plasticity at cortical inputs in the lateral amygdala
Menin (show MEN1 Antibodies) regulates spinal glutamate (show GRIN1 Antibodies)-GABA balance through GAD65 contributing to neuropathic pain.
Our data suggest a role of GAD65-mediated GABA synthesis in the encoding of circadian information to fear memory
Autoimmunity to GAD65 may play a role in the development of Stiff person syndrome.
Prenatal and postnatal maternal effects influence GAD65 and GAD67 (show GAD1 Antibodies) gene expression depending on the age of the offspring.
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
, glutamate decarboxylase 2
, glutamic acid decarboxylase
, 65 kDa glutamic acid decarboxylase
, Glutamate decarboxylase 2 (islet)
, glutamate decarboxylase 65 kDa isoform
, glutamic acid decarboxylase 2
, glutamic acid decarboxylase 65
, Glutamate decarboxylase-2 (pancreas)