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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Additionally we are shipping GRIK1 Antibodies (76) and GRIK1 Kits (24) and many more products for this protein.
Showing 6 out of 7 products:
Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 (show NETO1 Proteins) and Neto2 (show NETO2 Proteins) on the desensitization properties of GluK1 homomeric receptors
In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 (show OPRM1 Proteins) and GRIK1, rather than one gene polymorphism, is associated with smoking behavior.
This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period.
These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight.
Reduced Homer (show HOMER1 Proteins) binding to mGluR5 (show GRM5 Proteins) supports an inhibitory role for Homer (show HOMER1 Proteins) interactions with mGluR5 (show GRM5 Proteins) in mediating neuropathy.
Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART (show GART Proteins) gene in Down syndrome in India.
The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC (show FAM126A Proteins), suggesting the involvement of glutamate (show GRIN1 Proteins) signaling in the development of HBV-related HCC (show FAM126A Proteins).
GRIK1 rs469472 to be possibly associated with schizophrenia in our independent case-control and family samples
Presynaptic Gluk1 kainate receptors that reduce transmitter release downstream are independent of divalent calcium ion Ca2 (show CA2 Proteins)+ influx.
Animals trained in the trace fear conditioning protocol exhibited a transient increase in unedited GRIK1 RNA in the amygdala, and their learning efficiency correlated with unedited RNA levels in CA1 (show CA1 Proteins).
results show that GluK1 and Go proteins are natural partners, accounting for the metabotropic effects of Kainate receptors.
integrity of Homer (show HOMER1 Proteins) scaffolds is essential for normal glur5-evoked endocannabinoid functioning
We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli
The combined loss of the AMPA (show GRIA3 Proteins) receptor auxiliary TARPg-2 subunit and the GluK5 subunit leads to early mouse lethality.
CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
these data further implicate Group 1 mGluR (show GRM8 Proteins) signaling through Homer2 (show HOMER2 Proteins) within the nucleus accumbens in excessive alcohol consumption
This study demonistrated that grik1 gene expression in mouse dorsal raphe nucleus
Activation of presynaptic GluK1 kainate receptors at lateral amygdala synapses results in the inhibition of glutamate (show GRIN1 Proteins) release and the coupling of GluK1 receptors to a cascade involving the regulation of protein kinase A (PKA) activity.
This study demonistrated that glutamate signaling through mGluR5 located on dopamine D1 receptor-expressing neurons is necessary for incentive learning processes that contribute to cue-induced reinstatement of cocaine-seeking.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
glutamate receptor, ionotropic, kainate 1
, glutamate receptor, ionotropic kainate 1
, excitatory amino acid receptor 3
, glutamate receptor 5
, glutamate receptor ionotropic, kainate 1
, glutamate receptor subunit 5