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The protein encoded by GRIN1 is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. Additionally we are shipping GRIN1 Kits (24) and GRIN1 Proteins (10) and many more products for this protein.
Showing 10 out of 258 products:
Human Monoclonal GRIN1 Primary Antibody for BI, IHC - ABIN967491
Brose, Huntley, Stern-Bach, Sharma, Morrison, Heinemann: Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex. in The Journal of biological chemistry 1994
Show all 4 references for ABIN967491
Human Polyclonal GRIN1 Primary Antibody for IHC, ELISA - ABIN1531450
Foldes, Rampersad, Kamboj: Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing. in Gene 1993
Human Polyclonal GRIN1 Primary Antibody for WB - ABIN362728
Tyszkiewicz, Gu, Wang, Cai, Yan: Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex. in The Journal of physiology 2004
Rat (Rattus) Polyclonal GRIN1 Primary Antibody for ELISA, WB - ABIN185678
Rajji, Chapman, Eichenbaum, Greene: The role of CA3 hippocampal NMDA receptors in paired associate learning. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Knockdown of PKD1 (show PKD1 Antibodies) did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.
Study found GluN receptor subunit-specific changes in mixed subcortical ischemic vascular dementia(SIVD)/Alzheimer's disease(AD) (decreased GluN1) and SIVD (increased GluN2A (show GRIN2A Antibodies) and 2B), likely reflecting interaction of ischemic neurovascular and AD processes
The results of this study suggested that GRIN1 mutations cause encephalopathy resulting in seizures and movement disorders.
Genome-wide significant marker, SNP rs524991, and an association of seropositivity with influenza autoantibodies status, we provide genetic and environmental risk factors of NMDAR-autoantibodies formation
Epigenetic changes in GRIN1, in combination with experiences of maltreatment, may confer risk for depression in children.
Reduction in NR1 and NR2C (show GRIN2C Antibodies) in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.
Isolated GluN1/GluN3A (show GRIN3A Antibodies) receptors integrated into lipid bilayers responded to addition of either glycine or d-serine, but not glutamate, with a approximately 1 nm reduction in height of the extracellular domain
the levels were comparable for complexes containing GluR2 (show GRIA2 Antibodies), GluR3 (show GRIA3 Antibodies) and GluR4 (show GRIA4 Antibodies) as well as 5-HT1A (show HTR1A Antibodies). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 (show GRIA1 Antibodies) were significantly increased in male patients with AD.
Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A (show GRIN2A Antibodies) and GluN2B (show GRIN2B Antibodies) - together with that of postsynaptic protein PSD-95 (show DLG4 Antibodies) - are modified in Alzheimer's disease compared to normal aging
B7T inhibition of NMDA current mediated by NR1/NR2B (show GRIN2B Antibodies) receptor.
Establishment of late-phase long-term potentiation (L-LTP (show SCP2 Antibodies)) in vivo requires NMDAR activation in the postsynaptic tectal cells within a critical time window after LTP (show SCP2 Antibodies) induction.
PIP2 supports the open state of NMDA receptors via the adaptor protein alpha-actinin (show ACTN1 Antibodies). PIP2 and alpha-actinin (show ACTN1 Antibodies) act like a two-component hinge keeping the channel gate in its open state.
Deletion of the gene encoding the essential NR1 subunit of the NMDA receptor (NMDAR), restricted to the CA1 (show CA1 Antibodies) region of the hippocampus results in abnormal fear response in mice.
Heterozygous NR1 (+/-) mice with reduced glutamate function are more sensitive to the disruptive effects of social isolation.
EphB2 (show EPHB2 Antibodies) prevents amyloid-beta-induced depletion of cell surface GluN1 requiring the PDZ (show INADL Antibodies)-binding motif of EphB2 (show EPHB2 Antibodies)
The authors demonstrate that nascent granule cells lacking NMDARs but rescued from apoptosis by overexpressing the pro-survival protein Bcl2 (show BCL2 Antibodies) were deficient in spine formation.
GluN1 expression/enhanced glutamatergic function facilitates improved spatial memory in aldehyde dehydrogenase 2 deficient mice.
Study compared neuronal injury in the hippocampal CA1 (show CA1 Antibodies) region to that in PCs and investigated the role of NMDA receptors GluN2B (show GRIN2B Antibodies) and GluN1 in Purkinje cell injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation
selective disruption of Grin1 within central amygdala CRF (show CRH Antibodies) neurons strongly enhances fear memory
Results suggest that NMDA-receptor(Grin1)-mediated synaptic plasticity in the dorsal striatum contributes to strategy shifting and that striatal projection neurons of the direct pathway are particularly relevant for this process
Studied whether H2S supplementation reduces NMDA-R and MMP-9 (show MMP9 Antibodies)-induced dysfunction in diabetic kidney.
Studies provide evidence that N-methyl-D-aspartate receptor dependent neural signaling in the mPFC is a component of a neural mechanism for disambiguating the meaning of fear signals.
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
glutamate receptor, ionotropic, N-methyl D-aspartate 1
, NMDA-type glutamate receptor 1
, NMDA-type glutamate receptor subunit 1
, N-methyl-D-aspartate receptor 1
, glutamate [NMDA] receptor subunit zeta-1
, N-methyl-D-aspartate receptor channel, subunit zeta-1
, N-methyl-D-aspartate receptor subunit NR1
, glutamate [NMDA] receptor subunit zeta 1
, glutamate receptor ionotropic, NMDA 1
, N-methyl-D-aspartate glutamate receptor
, NMDA R1 receptor C1 cassette
, neurotransmitter receptor
, Glutamate [NMDA] receptor subunit zeta-1
, glutamate receptor subunit zeta 1
, N-methyl-D-aspartate receptor
, NMDA glutamate receptor
, N-methyl-D-aspartate receptor type 1
, NADPH-dependent diflavin oxidoreductase 1