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Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 Proteins (GRIN1)

The protein encoded by GRIN1 is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. Additionally we are shipping GRIN1 Antibodies (255) and GRIN1 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRIN1 2902 Q05586
Rat GRIN1 GRIN1 24408 P35439
GRIN1 14810 P35438
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Top GRIN1 Proteins at antibodies-online.com

Showing 6 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

GRIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) Interaction Partners

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. Knockdown of PKD1 (show PKD1 Proteins) did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.

  2. Study found GluN receptor subunit-specific changes in mixed subcortical ischemic vascular dementia(SIVD)/Alzheimer's disease(AD) (decreased GluN1) and SIVD (increased GluN2A (show GRIN2A Proteins) and 2B), likely reflecting interaction of ischemic neurovascular and AD processes

  3. The results of this study suggested that GRIN1 mutations cause encephalopathy resulting in seizures and movement disorders.

  4. Genome-wide significant marker, SNP rs524991, and an association of seropositivity with influenza autoantibodies status, we provide genetic and environmental risk factors of NMDAR-autoantibodies formation

  5. Epigenetic changes in GRIN1, in combination with experiences of maltreatment, may confer risk for depression in children.

  6. Reduction in NR1 and NR2C (show GRIN2C Proteins) in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.

  7. Isolated GluN1/GluN3A (show GRIN3A Proteins) receptors integrated into lipid bilayers responded to addition of either glycine or d-serine, but not glutamate, with a approximately 1 nm reduction in height of the extracellular domain

  8. the levels were comparable for complexes containing GluR2 (show GRIA2 Proteins), GluR3 (show GRIA3 Proteins) and GluR4 (show GRIA4 Proteins) as well as 5-HT1A (show HTR1A Proteins). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 and GluR1 (show GRIA1 Proteins) were significantly increased in male patients with AD.

  9. Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A (show GRIN2A Proteins) and GluN2B (show GRIN2B Proteins) - together with that of postsynaptic protein PSD-95 (show DLG4 Proteins) - are modified in Alzheimer's disease compared to normal aging

  10. B7T inhibition of NMDA current mediated by NR1/NR2B (show GRIN2B Proteins) receptor.

Xenopus laevis Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. Establishment of late-phase long-term potentiation (L-LTP (show SCP2 Proteins)) in vivo requires NMDAR activation in the postsynaptic tectal cells within a critical time window after LTP (show SCP2 Proteins) induction.

  2. PIP2 supports the open state of NMDA receptors via the adaptor protein alpha-actinin (show ACTN1 Proteins). PIP2 and alpha-actinin (show ACTN1 Proteins) act like a two-component hinge keeping the channel gate in its open state.

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. Study demonstrated that NMDAR functions are regulated by ghrelin (show GHRL Proteins) in a GHSR1a-dependent manner: NMDAR-mediated synaptic currents are increased as a result of GluN1 subunit phosphorylation in the hippocampal pyramidal neurons and synapses

  2. Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase (show RACGAP1 Proteins), Dexras1 (show RASD1 Proteins)

  3. Deletion of the gene encoding the essential NR1 subunit of the NMDA receptor (NMDAR), restricted to the CA1 (show CA1 Proteins) region of the hippocampus results in abnormal fear response in mice.

  4. Heterozygous NR1 (+/-) mice with reduced glutamate function are more sensitive to the disruptive effects of social isolation.

  5. EphB2 (show EPHB2 Proteins) prevents amyloid-beta-induced depletion of cell surface GluN1 requiring the PDZ-binding motif of EphB2 (show EPHB2 Proteins)

  6. The authors demonstrate that nascent granule cells lacking NMDARs but rescued from apoptosis by overexpressing the pro-survival protein Bcl2 (show BCL2 Proteins) were deficient in spine formation.

  7. GluN1 expression/enhanced glutamatergic function facilitates improved spatial memory in aldehyde dehydrogenase 2 deficient mice.

  8. Study compared neuronal injury in the hippocampal CA1 (show CA1 Proteins) region to that in PCs and investigated the role of NMDA receptors GluN2B (show GRIN2B Proteins) and GluN1 in Purkinje cell injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation

  9. selective disruption of Grin1 within central amygdala CRF (show CRH Proteins) neurons strongly enhances fear memory

  10. Results suggest that NMDA-receptor(Grin1)-mediated synaptic plasticity in the dorsal striatum contributes to strategy shifting and that striatal projection neurons of the direct pathway are particularly relevant for this process

GRIN1 Protein Profile

Protein Summary

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with GRIN1

  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (grin1)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1)
  • NMDA receptor 1 (Nmdar1)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (Grin1)
  • glutamate receptor, ionotropic, NMDA1 (zeta 1) (Grin1)
  • NADPH dependent diflavin oxidoreductase 1 (Ndor1)
  • 4930447P04Rik protein
  • GB19253 protein
  • GluN1 protein
  • GluRdelta1 protein
  • GluRzeta1 protein
  • GRIN1 protein
  • M100174 protein
  • MRD8 protein
  • Ndor protein
  • NMD-R1 protein
  • NMDA1 protein
  • Nmdar protein
  • NMDAR1 protein
  • NR1 protein
  • Rgsc174 protein

Protein level used designations for GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1 , NMDA-type glutamate receptor 1 , NMDA-type glutamate receptor subunit 1 , N-methyl-D-aspartate receptor 1 , glutamate [NMDA] receptor subunit zeta-1 , N-methyl-D-aspartate receptor channel, subunit zeta-1 , N-methyl-D-aspartate receptor subunit NR1 , NMD-R1 , glutamate [NMDA] receptor subunit zeta 1 , glutamate receptor ionotropic, NMDA 1 , N-methyl-D-aspartate glutamate receptor , NMDA R1 receptor C1 cassette , neurotransmitter receptor , Glutamate [NMDA] receptor subunit zeta-1 , glutamate receptor subunit zeta 1 , N-methyl-D-aspartate receptor , NMDA glutamate receptor , N-methyl-D-aspartate receptor type 1 , NADPH-dependent diflavin oxidoreductase 1

GENE ID SPECIES
780048 Xenopus (Silurana) tropicalis
100023485 Monodelphis domestica
406079 Apis mellifera
443281 Ovis aries
751779 Taeniopygia guttata
2902 Homo sapiens
24408 Rattus norvegicus
494007 Canis lupus familiaris
397953 Xenopus laevis
404296 Gallus gallus
14810 Mus musculus
78797 Mus musculus
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