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Glutamate Receptor, Ionotropic, delta 2 Proteins (GRID2)

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. Additionally we are shipping GRID2 Kits (30) and GRID2 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRID2 2895 O43424
GRID2 14804 Q61625
Rat GRID2 GRID2 79220 Q63226
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Top GRID2 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GRID2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Glutamate Receptor, Ionotropic, delta 2 (GRID2) Interaction Partners

Zebrafish Glutamate Receptor, Ionotropic, delta 2 (GRID2) interaction partners

  1. These results suggest that the expression of zebrafish GluRdelta2 is selective for cerebellum-like neural wiring with large numbers of parallel fiber inputs.

Human Glutamate Receptor, Ionotropic, delta 2 (GRID2) interaction partners

  1. Glutamate (show GRIN1 Proteins) system genes including have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium.

  2. findings suggest a possible role of GRID2 in the susceptibility to develop mevalonate kinase (show MVK Proteins) deficiency. GRID2 gene associated with MKD: The rs1450500 SNP was differently distributed in patients with MKD with respect to those with recurrent fever.

  3. We demonstrated for the first time GRID2 expression and localization in human and murine retina, providing evidence for a novel functional role of GRID2 in the retina.

  4. GRID2 point mutations: cerebellar ataxia (show USP14 Proteins) is the core phenotype, but with variable severity ranging from very mild adult-onset to congenital-onset linked to both the heterozygous and homozygous state of the variant, and the position of the mutation.

  5. GluD2 (show GLUD2 Proteins) gating is triggered by type 1 metabotropic glutamate (show GRIN1 Proteins) receptors.

  6. GRID2 mutations are associated with a recessive syndrome causing cerebellar ataxia (show USP14 Proteins) and eye movement abnormalities.

  7. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 (show ELAVL2 Proteins) among European mothers

  8. Glutamate (show GRIN1 Proteins) receptor delta2 is involved in a common mechanism that restricts the number of synaptic AMPA (show GRIA3 Proteins) receptors at parallel fiber synapses in cerebellar Purkinje cells.

  9. Thus, phosphorylation of -2T and/or -1S of GluRdelta2 C-terminus by PKA may regulate the binding of GluRdelta2 to its scaffolding protein, Delphilin (show GRID2IP Proteins).

  10. The carboxy terminus of transgenic GluRdelta2 conveys the signal(s) necessary for long-term depression induction and motor learning.

Mouse (Murine) Glutamate Receptor, Ionotropic, delta 2 (GRID2) interaction partners

  1. This study showed that spontaneous Grid2 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  2. Established is a mouse line with an autosomal recessive gene mutation characterized by progressive ataxia (show USP14 Proteins) and significant cerebellar atrophy.

  3. GluD2 (show GLUD2 Proteins) works in concert with GluD1 (show GLUD1 Proteins) for the construction of cerebellar synaptic wiring through distinct neuronal and synaptic expressions.

  4. Climbing fiber signals in Glu2 receptor delta2 knock-out mice propagate across multiple microzones.

  5. GluD2 (show GLUD2 Proteins) deletion impairs presynaptic R-type voltage-gated Ca(2 (show CA2 Proteins)+) channels, resulting in decreased release of synaptic vesicles

  6. The results suggest that multiple PC death pathways are induced by the physical trauma of making organotypic slice cultures, naturally-occurring postnatal cell death, and the GluRdelta2 (Lc) mutation.

  7. CD95 (show FAS Proteins) and soluble CD95L (show FASL Proteins) contribute, via non-apoptotic signaling, to the inflammatory reaction initiated early in neuron death within the Grid2(Lc/+) cerebellum

  8. activity-dependent phosphorylation of serine 880 (S880) in GluA2 (show GRIA2 Proteins) AMPA (show GRIA3 Proteins) receptor subunit, which is an essential step for AMPA (show GRIA3 Proteins) receptor endocytosis during LTD induction, was impaired in GluD2 (show GLUD2 Proteins)-null cerebellum

  9. GluRdelta2 is part of the mGluR1 (show GRM1 Proteins) signaling complex needed for cerebellar synaptic function and motor coordination

  10. [review] The Cbln1 (show CBLN1 Proteins)-GluRdelta2 receptor complex is located at the cleft of parallel fiber-Purkinje cell synapses and bidirectionally regulates both presynaptic and postsynaptic differentiation.

GRID2 Protein Profile

Protein Summary

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.

Gene names and symbols associated with GRID2

  • glutamate receptor, ionotropic, delta 2 (grid2)
  • glutamate receptor, ionotropic, delta 2 (GRID2)
  • glutamate receptor, ionotropic, delta 2 (Grid2)
  • B230104L07Rik protein
  • cpr protein
  • GluD2 protein
  • glurd2 protein
  • GluRdelta2 protein
  • GRID2 protein
  • ho protein
  • Lc protein
  • Lc protein
  • MMS10-AC protein
  • Ms10ac protein
  • nmf408 protein
  • si:rp71-1l7.1 protein
  • tpr protein

Protein level used designations for GRID2

gluR delta-2 subunit , glutamate receptor delta-2 subunit , glutamate receptor ionotropic, delta-2 , glutamate receptor, ionotropic, delta 2 , glutamate receptor delta-2 subunit-like , GluR-delta-2 , creeper , hotfoot , lurcher , minisatellite 10ac detected by probe MMS10

GENE ID SPECIES
448841 Danio rerio
704787 Macaca mulatta
743067 Pan troglodytes
100025741 Monodelphis domestica
100400487 Callithrix jacchus
100599647 Nomascus leucogenys
2895 Homo sapiens
14804 Mus musculus
79220 Rattus norvegicus
100342468 Oryctolagus cuniculus
100735199 Cavia porcellus
100516747 Sus scrofa
487863 Canis lupus familiaris
536367 Bos taurus
422520 Gallus gallus
101117078 Ovis aries
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