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anti-Glutamate Receptor, Metabotropic 1 (GRM1) Antibodies

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Kits (18) and Metabotropic Glutamate Receptor 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM1 2911 Q13255
GRM1 14816 P97772
GRM1 24414 P23385
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Top anti-Metabotropic Glutamate Receptor 1 Antibodies at antibodies-online.com

Showing 10 out of 136 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB GRM1 Antibody (C-term) (ABIN657624) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the GRM1 antibody detected the GRM1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRM1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB GPRC1A Antibody (Y1111) (ABIN652203) western blot analysis in NCI-H460 cell line lysates (35 µg/lane).This demonstrates the GPRC1A antibody detected the GPRC1A protein (arrow). Metabotropic Glutamate Receptor 1 (GPRC1A) Antibody (C-term) (ABIN652203)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Rat Rabbit Un-conjugated IHC (fro), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated FACS, IP, IHC, WB Western blot analysis of rat brain lysate: 1. Anti-mGluR1 (extracellular) antibody, (1:200). 2. Anti-mGluR1 (extracellular) antibody, preincubated with the control peptide antigen. Western blot analysis of mouse brain lysate: 1. Anti-mGluR1 (extracellular) antibody, (1:200). 2. Anti-mGluR1 (extracellular) antibody, preincubated with the control peptide antigen. 50 μL Log in to see 10 to 11 Days
$678.57
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of mGluR1 on a rat cerebrum lysate. Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1: 10,000 dilution of the mouse anti-mGluR1 antibody. Immunofluorescence staining of cortical neurons. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated FACS, IP Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 0.1 mg Log in to see 4 to 5 Days
$231.00
Details
Human Mouse Un-conjugated FACS Surface staining of lysed and washed porcine peripheral blood with purified anti-CD16 (MEM-168) (detection by anti-mouse IgM FITC). Panel A - porcine PBMC stained with Isotype mouse IgM control (PFR-03) Panel B, C, D - three different porcine PMBC samples stained with anti-CD16 Cells in the granulocyte gate were used for analysis. 0.1 mg Log in to see 4 to 5 Days
$231.00
Details
Human Mouse FITC FACS Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 100 Tests Log in to see 4 to 5 Days
$288.75
Details
Human Mouse PE FACS Surface staining of human peripheral blood cells with anti-CD16 (LNK16) PE. 100 Tests Log in to see 4 to 5 Days
$334.95
Details

GRM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Metabotropic Glutamate Receptor 1 Antibodies

  1. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS - ABIN93990 : Kahn, Moergelin, Shannon, Norrby-Teglund, Herwald, Olin, Bjoerck: Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response. in PLoS pathogens 2008 (PubMed)
    Show all 14 references for ABIN93990

  2. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, IP - ABIN93988 : Mathison, Christie, Davison: The tripeptide feG inhibits leukocyte adhesion. in Journal of inflammation (London, England) 2008 (PubMed)
    Show all 14 references for ABIN93988

  3. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS - ABIN93989 : Meknache, Joensson, Laurent, Guinnepain, Daueron: Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B). in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 14 references for ABIN93989

  4. Mouse (Murine) Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IF, WB - ABIN968280 : Gomeza, Joly, Kuhn, Knöpfel, Bockaert, Pin: The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. in The Journal of biological chemistry 1996 (PubMed)
    Show all 5 references for ABIN968280

  5. Rat (Rattus) Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC (fro), WB - ABIN372668 : Blaabjerg, Fang, Zimmer, Baskys: Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. in Experimental neurology 2003 (PubMed)
    Show all 4 references for ABIN372668

  6. Human Monoclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS - ABIN93997 : Drbal, Moertelmaier, Holzhauser, Muhammad, Fuertbauer, Howorka, Hinterberger, Stockinger, Schütz: Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement. in International immunology 2007 (PubMed)
    Show all 4 references for ABIN93997

  7. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC, ELISA - ABIN1535754 : Stephan, Bon, Holzwarth, Galvan, Pruss: Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. in Neuropharmacology 1997 (PubMed)
    Show all 2 references for ABIN1535754

  8. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for FACS, IP - ABIN1742082 : Ferraguti, Shigemoto: Metabotropic glutamate receptors. in Cell and tissue research 2006 (PubMed)

  9. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for IHC (p), WB - ABIN652203 : Hlavackova, Goudet, Kniazeff, Zikova, Maurel, Vol, Trojanova, Prézeau, Pin, Blahos: Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. in The EMBO journal 2005 (PubMed)

  10. Human Polyclonal Metabotropic Glutamate Receptor 1 Primary Antibody for WB - ABIN657624 : Jiang, Huang, Wong, Zhou, Wang, Yang, Hall, Brown, Yang: Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against Metabotropic Glutamate Receptor 1 Interaction Partners

Human Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1 (show TRMT1 Antibodies), both of which were found to co-segregate with the intellectual disability.

  2. It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor (show ADORA1 Antibodies) and mutually modulate signaling.

  3. These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.

  4. Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.

  5. elevated glutamate (show GRIN1 Antibodies) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation

  6. alpha-actinin-4 (show ACTN4 Antibodies) is a novel group 1 mGluR (show GRM8 Antibodies)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.

  7. Deleterious GRM1 mutations are associated with schizophrenia.

  8. These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.

  9. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor (show VEGFA Antibodies) as well as a mediator of tumor progression.

  10. In mice expressing mutant beta-III spectrin (show SPTBN2 Antibodies), mGluR1 localization is altered at Purkinje cell dendritic spines.

Mouse (Murine) Glutamate Receptor, Metabotropic 1 (GRM1) interaction partners

  1. Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3 (show STAT3 Antibodies)-mGluR1 and PI3K-p53 (show TP53 Antibodies) signaling.

  2. Because the mGluR1-PKCgamma (show PRKCG Antibodies) signaling pathway is essential for the late-phase of climbing fiber synapse elimination, this signaling pathway promotes the two key features of excitatory synaptic wiring in Purkinje cells.

  3. Numb (show NUMB Antibodies) is a regulator for constitutive expression and dynamic transport of mGlu1.

  4. CaMKIIalpha (show CAMK2 Antibodies) selectively regulates mGluR1a and mGluR5a ERK1/2 (show MAPK1/3 Antibodies) signaling.

  5. STIM1 (show STIM1 Antibodies) is a key regulator of mGluR1-dependent Ca(2 (show CA2 Antibodies)+) signaling.

  6. Selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate (show GRIN1 Antibodies) receptors.

  7. Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri (show POSTN Antibodies)-junctional enrichment in glutamatergic synapses

  8. Activation of mGluR1 facilitates firing of molecular layer interneurons through the TRPC1 (show TRPC1 Antibodies)-mediated inward current, which depends on not only G protein-dependent but also Src (show SRC Antibodies)-ERK1/2 (show MAPK1/3 Antibodies)-dependent signaling pathways.

  9. Homer (show HOMER1 Antibodies) 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate (show GRIN1 Antibodies) receptors.

  10. Stimulation of mGluR1 during glutamate (show GRIN1 Antibodies) exposure mediates prolonged epileptiform discharges in the hippocampus.

Metabotropic Glutamate Receptor 1 (GRM1) Antigen Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.

Gene names and symbols associated with GRM1

  • glutamate receptor, metabotropic 1 (GRM1) antibody
  • glutamate receptor, metabotropic 1a (grm1a) antibody
  • metabotropic glutamate receptor 1 (mGlutR1) antibody
  • glutamate receptor, metabotropic 1 (Grm1) antibody
  • 4930455H15Rik antibody
  • ENSMUSG00000075319 antibody
  • fj39d05 antibody
  • GB18621 antibody
  • Glura antibody
  • Gm10828 antibody
  • Gprc1a antibody
  • MGLU1 antibody
  • mGluR1 antibody
  • mGlutR antibody
  • nmf373 antibody
  • rcw antibody
  • SCAR13 antibody
  • si:ch211-51a19.1 antibody
  • wobl antibody
  • wu:fj39d05 antibody

Protein level used designations for GRM1

metabotropic glutamate receptor 1 , metabotropic glutamate receptor A , G protein coupled receptor, family C, group 1, member A , G protein-coupled receptor, family C, group 1, member A , G protein coupled receptor family C group 1 member A , mGluR1

GENE ID SPECIES
100060603 Equus caballus
463049 Pan troglodytes
555576 Danio rerio
406151 Apis mellifera
2911 Homo sapiens
100625610 Sus scrofa
14816 Mus musculus
24414 Rattus norvegicus
421614 Gallus gallus
484024 Canis lupus familiaris
540485 Bos taurus
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