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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Antibodies (137) and Metabotropic Glutamate Receptor 1 Kits (14) and many more products for this protein.
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a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1 (show TRMT1 Proteins), both of which were found to co-segregate with the intellectual disability.
It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling.
These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.
Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.
elevated glutamate (show GRIN1 Proteins) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation
alpha-actinin-4 (show ACTN4 Proteins) is a novel group 1 mGluR (show GRM8 Proteins)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.
Deleterious GRM1 mutations are associated with schizophrenia.
These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.
Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor (show VEGFA Proteins) as well as a mediator of tumor progression.
In mice expressing mutant beta-III spectrin, mGluR1 localization is altered at Purkinje cell dendritic spines.
Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of mGlu1alpha. The expression of stress-alcohol locomotor cross-sensitization was associated with lower mGlu1alpha within the NAC core.
Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3 (show STAT3 Proteins)-mGluR1 and PI3K-p53 (show TP53 Proteins) signaling.
Because the mGluR1-PKCgamma (show PRKCG Proteins) signaling pathway is essential for the late-phase of climbing fiber synapse elimination, this signaling pathway promotes the two key features of excitatory synaptic wiring in Purkinje cells.
Numb (show NUMB Proteins) is a regulator for constitutive expression and dynamic transport of mGlu1.
CaMKIIalpha selectively regulates mGluR1a and mGluR5a ERK1/2 signaling.
STIM1 (show STIM1 Proteins) is a key regulator of mGluR1-dependent Ca(2 (show CA2 Proteins)+) signaling.
Selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate (show GRIN1 Proteins) receptors.
Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri (show POSTN Proteins)-junctional enrichment in glutamatergic synapses
Activation of mGluR1 facilitates firing of molecular layer interneurons through the TRPC1-mediated inward current, which depends on not only G protein-dependent but also Src-ERK1/2-dependent signaling pathways.
Homer (show HOMER1 Proteins) 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate (show GRIN1 Proteins) receptors.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.
metabotropic glutamate receptor 1
, metabotropic glutamate receptor A
, G protein coupled receptor, family C, group 1, member A
, G protein-coupled receptor, family C, group 1, member A
, G protein coupled receptor family C group 1 member A