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anti-Glutamate Receptor, Metabotropic 2 (GRM2) Antibodies

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM2 Kits (27) and GRM2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GRM2 2912 Q14416
GRM2 108068 Q14BI2
GRM2 24415 P31421
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Top anti-GRM2 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of rat cerebellum (lanes 1 and 3) and cortex (lanes 2 and 4) membranes: 1, 2. Anti-mGluR2 (extracellular) antibody, (1:400). 3, 4. Anti-mGluR2 (extracellular) antibody, preincubated with the control peptide antigen. Western blot analysis of mouse brain membranes: 1. Anti-mGluR2 (extracellular) antibody, (1:200). 2. Anti-mGluR2 antibody, preincubated with the control peptide antigen. 50 μL Log in to see 10 to 11 Days
$678.57
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Cow Rabbit Un-conjugated IF, IHC (p), WB Immunohistochemical staining of Brain (Neurons and glia) using anti- GRM2 antibody ABIN122313 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GRM2 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of LOVO cells, using GRM2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-GRM2 / MGLUR2 antibody  ABIN1048930 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Rat Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged GRM2 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB Anti-GRM2 / MGLUR2 antibody  ABIN1048929 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-GRM2 / MGLUR2 antibody  ABIN1048928 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details

GRM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GRM2 Antibodies

  1. Human Polyclonal GRM2 Primary Antibody for IHC, WB - ABIN1742078 : Conn, Pin: Pharmacology and functions of metabotropic glutamate receptors. in Annual review of pharmacology and toxicology 1997 (PubMed)

More Antibodies against GRM2 Interaction Partners

Human Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. Allosteric signaling through an mGlu2 and 5-HT2A (show HTR2A Antibodies) heteromeric receptor complex and its potential contribution to schizophrenia.

  2. Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.

  3. Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia

  4. Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density

  5. Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects

  6. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.

  7. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5 (show GRM5 Antibodies), and GRIA3 (show GRIA3 Antibodies) genes increased significantly in patients in comparison to healthy controls.

  8. the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.

  9. Only full-length dimeric mGlu2 activates G protein upon glutamate (show GRIN1 Antibodies) binding.

  10. Suggest a genetic association exists between SNPs in several genes, such as HTR2A (show HTR2A Antibodies) and NRG1 (show NRG1 Antibodies), and response to mGlu2/3 agonist LY2140023 treatment in schizophrenia.

Mouse (Murine) Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. Allosteric signaling through an mGlu2 and 5-HT2A (show HTR2A Antibodies) heteromeric receptor complex and its potential contribution to schizophrenia.

  2. provided evidence that JARID1B (show KDM5B Antibodies) via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB

  3. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 Antibodies)+) transients and striatal field potentials.

  4. In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice.

  5. The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders

  6. mGluR3 (show GRM3 Antibodies) knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior.

  7. In the central nervous system, mGluR2 and mGluR4 (show GRM4 Antibodies) form a hetero-complex with a distinct pharmacological profile.

  8. The reduction in the expression of mGluR2 and mGluR3 (show GRM3 Antibodies) may be involved in the development of benzodiazepine dependence.

  9. 5-HT(2A (show HTR2A Antibodies)) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex.

  10. The mGluR2 subtype activates an inwardly rectifying potassium conductance in dendrites of the dentate gyrus.

GRM2 Antigen Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GRM2

  • glutamate receptor, metabotropic 2 (GRM2) antibody
  • glutamate receptor, metabotropic 2 (Grm2) antibody
  • 4930441L02Rik antibody
  • GLUR2 antibody
  • Gprc1b antibody
  • mGlu2 antibody
  • mGluR2 antibody
  • mGluR7 antibody

Protein level used designations for GRM2

glutamate metabotropic receptor 2 , glutamate receptor homolog , metabotropic glutamate receptor 2 , G protein coupled receptor, family C, group 1, member B , G protein-coupled receptor, family C, group 1, member B , mGluR2

GENE ID SPECIES
2912 Homo sapiens
108068 Mus musculus
24415 Rattus norvegicus
427575 Gallus gallus
519904 Bos taurus
484751 Canis lupus familiaris
101116870 Ovis aries
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