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Glutamate Receptor, Metabotropic 2 Proteins (GRM2)

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping GRM2 Antibodies (97) and GRM2 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRM2 2912 Q14416
GRM2 108068 Q14BI2
Rat GRM2 GRM2 24415 P31421
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Top GRM2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

GRM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Glutamate Receptor, Metabotropic 2 (GRM2) Interaction Partners

Human Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

  2. Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.

  3. Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia

  4. Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density

  5. Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects

  6. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.

  7. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5 (show GRM5 Proteins), and GRIA3 (show GRIA3 Proteins) genes increased significantly in patients in comparison to healthy controls.

  8. the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.

  9. Only full-length dimeric mGlu2 activates G protein upon glutamate (show GRIN1 Proteins) binding.

  10. Suggest a genetic association exists between SNPs in several genes, such as HTR2A and NRG1 (show NRG1 Proteins), and response to mGlu2/3 agonist LY2140023 treatment in schizophrenia.

Mouse (Murine) Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

  2. provided evidence that JARID1B (show KDM5B Proteins) via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB

  3. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 Proteins)+) transients and striatal field potentials.

  4. In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice.

  5. The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders

  6. mGluR3 (show GRM3 Proteins) knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior.

  7. In the central nervous system, mGluR2 and mGluR4 (show GRM4 Proteins) form a hetero-complex with a distinct pharmacological profile.

  8. The reduction in the expression of mGluR2 and mGluR3 (show GRM3 Proteins) may be involved in the development of benzodiazepine dependence.

  9. 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex.

  10. The mGluR2 subtype activates an inwardly rectifying potassium conductance in dendrites of the dentate gyrus.

GRM2 Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GRM2

  • glutamate receptor, metabotropic 2 (GRM2)
  • glutamate receptor, metabotropic 2 (Grm2)
  • 4930441L02Rik protein
  • GLUR2 protein
  • Gprc1b protein
  • mGlu2 protein
  • mGluR2 protein
  • mGluR7 protein

Protein level used designations for GRM2

glutamate metabotropic receptor 2 , glutamate receptor homolog , metabotropic glutamate receptor 2 , G protein coupled receptor, family C, group 1, member B , G protein-coupled receptor, family C, group 1, member B , mGluR2

GENE ID SPECIES
2912 Homo sapiens
108068 Mus musculus
24415 Rattus norvegicus
427575 Gallus gallus
519904 Bos taurus
484751 Canis lupus familiaris
101116870 Ovis aries
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