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Glutamate Receptor, Metabotropic 3 Proteins (GRM3)

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 3 Antibodies (83) and Metabotropic Glutamate Receptor 3 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRM3 2913 Q14832
GRM3 108069 Q9QYS2
Rat GRM3 GRM3 24416 P31422
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Top Metabotropic Glutamate Receptor 3 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

GRM3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Glutamate Receptor, Metabotropic 3 (GRM3) Interaction Partners

Human Glutamate Receptor, Metabotropic 3 (GRM3) interaction partners

  1. Significant association was found between rs12704290 in GRM3 gene and schizophrenia(SCZ). A three-SNP LD spanning GRM3Delta4 splice site was significantly associated with SCZ. Interaction between the LD block and cognitive function was found in SCZ patients.

  2. Results show that GRM3 rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype

  3. Grm3 expression was decreased in B cells from patients with autoimmune diseases such as activated systemic lupus erythematosus and multiple sclerosis.

  4. Pharmacogenetic relationships were identified in patients with schizophrenia between GRM3 variants and symptom response to antipsychotics.

  5. PI4KA (show PI4KA Proteins) and GRM3 polymorphisms have potential to jointly modulate antipsychotic response

  6. Findings suggest that mGluR2 (show GRM2 Proteins)/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia

  7. Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2 (show GRM2 Proteins)/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density

  8. The mGluR3 promoted the proliferation of human embryonic cortical NPCs and increased cyclin D1 (show CCND1 Proteins) expression by activating ERK1/2 and JNK2 (show MAPK9 Proteins) signaling pathways.

  9. The data of this study suggest an association of the GRM3 rs6465084 polymorphism with changes in pursuit maintenance after antipsychotic treatment.

  10. This study provided that the evidence for an association between GRM3 genotype and schizophrenia and suggest a role for glutamate (show GRIN1 Proteins) neurotransmission in the establishment and maintenance of myelinated fibers.

Mouse (Murine) Glutamate Receptor, Metabotropic 3 (GRM3) interaction partners

  1. provided evidence that JARID1B (show KDM5B Proteins) via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB

  2. Activation of GABA(B) or mGlu2 (show GRM2 Proteins)/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 Proteins)+) transients and striatal field potentials.

  3. Activation of Grm3 ameliorates lupus-like disease in mice by reducing B cell numbers. Grm3 expression on B-cells is decreased in lupus-prone mice.

  4. The number of mGluR3-immunoractive cells was significantly reduced in the dorsal and intermediate but not ventral parts of the lateral septum in postpartum versus virgin females.

  5. GRM3-knockout mice exhibit a biphasic effect in spatial working memory, initially impaired but performing better after training.

  6. The results of these studies implicate mGlu3 as a major regulator of PFC (show CFP Proteins) function and cognition.

  7. This study demonistrated that mGluR3 knockout mice show a working memory defect.

  8. report we describe a novel neuroprotective function of mGlu3 receptors related to their ability to promote the non-amyloidogenic pathway of APP (show APP Proteins) cleavage in astrocytes, thus enhancing sAPPalpha production

  9. The findings support the possibility that interactions between mGlu2 (show GRM2 Proteins)/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders

  10. mGluR3 knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 (show GRM2 Proteins) receptors are critical in mediating addictive-like behavior.

Metabotropic Glutamate Receptor 3 (GRM3) Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene names and symbols associated with GRM3

  • glutamate receptor, metabotropic 3 (GRM3)
  • glutamate receptor, metabotropic 3 (Grm3)
  • 0710001G23Rik protein
  • GLUR3 protein
  • Gprc1c protein
  • mGlu3 protein
  • mGluR3 protein

Protein level used designations for GRM3

metabotropic glutamate receptor 3 , glutamate metabotropic receptor 3 , G protein-coupled receptor, family C, group 1, member C , mGluR3

GENE ID SPECIES
541056 Bos taurus
2913 Homo sapiens
108069 Mus musculus
24416 Rattus norvegicus
100172627 Pongo abelii
101113057 Ovis aries
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