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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 4 Antibodies (39) and Metabotropic Glutamate Receptor 4 Kits (19) and many more products for this protein.
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The GRM4 gene polymorphism was associated with the susceptibility and metastasis of osteosarcoma in a Chinese Han population.
The major depression subjects exhibited significantly higher expression level in the metabotropic receptor genes GRM4 in Locus coeruleus neurons.
explored the relationship between the binding pockets of mGlu4-positive allosteric modulators with different chemical scaffolds and their functional properties
Data show that mGlu2 (show GRM2 Proteins) and mGlu4 subunits (but not mGlu2 (show GRM2 Proteins) and mGlu1 (show GRM1 Proteins)) can heteromerize.
GRM4 sequence variants might confer low-risk effects to the etiology of idiopathic generalized epilepsies.
residues shaping the binding pocket determine ligand selectivity for mGLUR4
mGluR4 has a role in 5-FU resistance in colonic neoplasms
Results suggest that overexpression of mGluR4 is associated with poor prognosis.
mGluR4 internalization and desensitization are agonist-independent unless pathways leading to the activation of PKC are induced.
These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas.
Results offer the first evidence that changes in the striatal expression of mGlu4 and mGlu5 (show GRM5 Proteins) receptors occur in acute models of parkinsonisms
Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice
A functional hetero-complex is formed with mGluR2 (show GRM2 Proteins) and mGluR4 in central nervous system.
mGluR4-/- mice show increased long-term potentiation in hippocampal CA1 (show CA1 Proteins) region and improved maze learning.
data support a role for mGluR4 signaling in acquisition of fear learning and memory.
The expression of mGluR4 is down-regulated in the cardiomyocyte differentiation of embryonic stem cells.
These data indicate that effects of mGluR4 on sensorimotor function and measures of anxiety, but not cued fear conditioning, are critically modulated by sex and age.
A role for mGlu4 was found whereby simultaneous activation with GABA(A) receptors acts to amplify glutamate (show GRIN1 Proteins) release at parallel fiber-Purkinje cell synapses.
These data indicate that activation of mGlu4 receptors limit the development of brain damage after permanent or transient focal ischemia
Grm4 modulates adaptive immunity and restrains neuroinflammation.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
metabotropic glutamate receptor 4
, G protein-coupled receptor GRM4
, G protein-coupled receptor, family C, group 1, member D