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has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina [RGD, Feb 2006].. Additionally we are shipping Metabotropic Glutamate Receptor 6 Antibodies (99) and Metabotropic Glutamate Receptor 6 Kits (15) and many more products for this protein.
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Two mutations in GRM6 gene have been identified in two consanguineous Pakistani families with congenital stationary night blindness.
These data suggest differences in coupling of TRPM1 (show TRPM1 Proteins) function to mGluR6 signaling explain different cellular responses to glutamate (show GRIN1 Proteins) in the retina and the skin.
We found 5 different mutations in GRM6, in congenital stationary night blindness.
The selective thinning of the inner retinal layers in patients with GRM6 mutations suggests either reduced bipolar or ganglion cell numbers or altered synaptic structure in the inner retina.
The results expand the mutation spectrum of NYX (show NYX Proteins), CACNA1F (show CACNA1F Proteins) and GRM6. They also suggest that NYX (show NYX Proteins) mutations are a common cause of congenital stationary night blindness (CSNB (show CSN2 Proteins)).
The phenotype associated with GRM6 mutation is variable in terms of presentation, refractive error, visual acuity and macular function. ERGs are electronegative and suggest ON-pathway dysfunction.
A positive association was observed between response to methadone and two variants in the genes MYOCD and GRM6.
Affected individuals in three of five families carried either compound heterozygous or homozygous mutations in GRM6.
The ligand-binding and the poorly characterized cysteine-rich domains, in addition to the intracellular domains, have a pivotal role in correct trafficking of metabotropic glutamate (show GRIN1 Proteins) receptors to the cell surface.
A switch in G-protein coupling, in which glutamate775lysine loses G(o) subunit coupling but retains coupling to G(i), may explain the highly specialized metabotropic glutamate (show GRIN1 Proteins) receptor mGlur6 phenotype.
These results indicate that Grm6 nob7 is a new model of the complete form of congenital stationary night blindness.
The mGluR6-KO phenotype showed negative effects on ribbon synapse formation.
Diagnosis of concurrent Stargardt disease and CSNB (show CSN2 Proteins) was made on the ophthalmic history; genetic testing revealed two previously reported mutations in the ABCA4 (show ABCA4 Proteins) gene and two novel deletions in the GRM6 gene.
the localization and stability of Cacna1s (show CACNA1S Proteins) depend on the expression of mGluR6 and its cascade components, and they suggest that Cacna1s (show CACNA1S Proteins) is part of the mGluR6 complex.
The results suggested that the TRPM1 (show TRPM1 Proteins) channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.
These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs.
The mGluR6 mRNA levels are altered in the young and adult rat retina of Royal College of Surgeons rat and suggest that the genetically induced degeneration of photoreceptors affects the expression of this receptor by the INL retinal neurons.
In mGluR6-null mice, long-latency ON responses are observed in the visual cortex, indicating that they can be conducted reliably to higher visual areas.
mGluR6 expression was limited to the outer plexiform layer
Visual responses of Grm6(no b-wave3 (show WASF3 Proteins)) retinal ganglion cells to light onset were abnormal.
has adenylate cyclase inhibiting metabotropic glutamate receptor activity\; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina
metabotropic glutamate receptor 6
, G protein-coupled receptor GRM6
, G protein-coupled receptor, family C, group 1, member F