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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. Additionally we are shipping Glutamate-Cysteine Ligase, Catalytic Subunit Kits (23) and Glutamate-Cysteine Ligase, Catalytic Subunit Proteins (12) and many more products for this protein.
Showing 10 out of 137 products:
Human Monoclonal GCLC Primary Antibody for IF, ELISA - ABIN561050
Hardwick, Fisher, Canet, Lake, Cherrington: Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. in Drug metabolism and disposition: the biological fate of chemicals 2010
Show all 6 references for ABIN561050
Human Polyclonal GCLC Primary Antibody for EIA, FACS - ABIN952477
Man, Baum, Fu, Chan, Lam, Hui, Leung, Wong: Genetic polymorphisms of Chinese patients with ischemic stroke and concurrent stenoses of extracranial and intracranial vessels. in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010
Show all 3 references for ABIN952477
Human Polyclonal GCLC Primary Antibody for IHC, WB - ABIN2785780
Bardag-Gorce, Oliva, Lin, Li, French, French: Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. in Experimental and molecular pathology 2011
Show all 2 references for ABIN2785780
Cow (Bovine) Polyclonal GCLC Primary Antibody for WB - ABIN2774078
Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. in International archives of occupational and environmental health 2008
Cow (Bovine) Polyclonal GCLC Primary Antibody for IP, WB - ABIN4313738
Theodoratos, Blackburn, Cappello, Tummala, Dahlstrom, Board: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase. in Biochemical pharmacology 2011
Microarray analysis revealed that glutamate (show GRIN2A Antibodies) cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.
investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels
Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies
The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP.
that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression.
GSH biosynthesis in the nucleus is associated with migration of only the GCLc subunit from the cytoplasm into the nucleus, and this migration requires the presence of an intact nuclear localization signal
Glutaminolysis is activated in ES2 (show DGCR14 Antibodies) and OVCAR3, though ES2 (show DGCR14 Antibodies) exclusively synthesizes amino acids and GSH. ES2 (show DGCR14 Antibodies) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (show DGCR14 Antibodies) to carboplatin. HNF1beta (show HNF1B Antibodies) regulates the expression of GCLC, but not GCLM (show GCLM Antibodies), and consequently GSH production in ES2 (show DGCR14 Antibodies)
miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.
Data suggest expression of hepatocyte GCLC and GCLM (show GCLM Antibodies) can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC and GCLM (show GCLM Antibodies) expression.
Cigarette smoke-induced hypermethylation of the GCLC promoter is related to the initiation and progression of COPD (show ARCN1 Antibodies).
GCLC and GSS (show GSS Antibodies) were expressed at higher levels in colon cancer tissue, as compared with normal mucosa.
The Kaplan-Meier analysis shows that rs3736729 on GCLC presents a significant association with disease-free survival and overall survival.
H2S upregulates GCLC and GSH and inhibits IL-1beta (show IL1B Antibodies) levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis
the CYP1A1 (show CYP1A1 Antibodies) (rs2606345, rs4646903, rs1048943), GCLC, AGT (show AGXT Antibodies), and AGTR1 (show AGTR1 Antibodies) genes was associated with pleuritis, empyema, acute respiratory distress syndrome, all PC and acute respiratory failure (ARF (show CDKN2A Antibodies)).
A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.
These data strongly indicate a discrepancy between the regulation of GCLC and of GGT following the oxidative stress situation due to mitochondrial uncoupling.
A floxed Gclc mouse was generated and crossed with a transgenic mouse expressing Cre in the lens to generate the Lens Glutathione Synthesis Knockout mouse in which de novo GSH synthesis was completely abolished in the lens.
Clinically relevant levels of TGF-beta1 (show TGFB1 Antibodies) suppresses GCLC and GCLM (show GCLM Antibodies) expression in mouse lung.
Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.
The impacts of four clinical missense mutations on GCLC enzymatic function in vivo and in vitro, was evaluated.
tBHQ has beneficial effects on reducing hyperglycemia-induced kidney injury, which is associated with the enhanced expression of Nrf2 (show NFE2L2 Antibodies), and its downstream antioxidant HO-1 (show HMOX1 Antibodies) and gamma-GCS (show UGCG Antibodies) in the glomeruli of diabetic mice
In first days of life luminescence measured was in all mice with distinct strain differences indicating NF-kappaB (show NFKB1 Antibodies), superoxide dismutase (show SOD1 Antibodies), gamma-glutamylcysteine synthetase, and antioxidant responsive element activity.
Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 184.108.40.206) and glutathione synthase (show GSS Antibodies) (GS) (E.C. 220.127.116.11)
activation of GSK-3beta (show GSK3b Antibodies) is a key mediator of the initial phase of acetaminophen-induced liver injury through modulating GCL and Mcl-1 (show MCL1 Antibodies) degradation, as well as JNK (show MAPK8 Antibodies) activation in liver
These findings demonstrate that TAT (show TAT Antibodies)-mediated transduction of wild-type or dominant-inhibitory mutants of the Glutamate cysteine ligase (GCL) subunits is a viable means of manipulating cellular GCL activity.
The GCLc protein was widely expressed throughout the embryo, and, in general, it co-localized with the Gclc mRNA.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
glutamate--cysteine ligase catalytic subunit
, glutamate-cysteine ligase, catalytic subunit
, gamma-Glutamylcysteine synthetase
, gamma-Glutamylcysteine synthetase catalytic subunit
, gamma-glutamylcysteine ligase
, glutamate cysteine ligase
, glutamate-cysteine ligase
, gamma glutamylcysteine synthetase
, glutamate--cysteine ligase, chloroplastic
, GCS heavy chain
, gamma-glutamylcysteine synthetase
, gamma GCS-HS
, gamma-glutamylcysteine synthetase heavy subunit
, Glutamylcysteine gamma synthetase light chain
, glutamate-cysteine ligase catalytic subunit