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Glutamate-Cysteine Ligase, Catalytic Subunit Proteins (GCLC)

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. Additionally we are shipping Glutamate-Cysteine Ligase, Catalytic Subunit Antibodies (127) and Glutamate-Cysteine Ligase, Catalytic Subunit Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCLC 2729 P48506
GCLC 14629 P97494
GCLC 25283 P19468
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Top Glutamate-Cysteine Ligase, Catalytic Subunit Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$816.20
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,844.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details

GCLC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Interaction Partners

Fruit Fly (Drosophila melanogaster) Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. Microarray analysis revealed that glutamate (show GRIN2A Proteins) cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.

  2. investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels

  3. Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies

  4. The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP.

  5. that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression.

  6. GSH biosynthesis in the nucleus is associated with migration of only the GCLc subunit from the cytoplasm into the nucleus, and this migration requires the presence of an intact nuclear localization signal

Human Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  2. Data suggest expression of hepatocyte GCLC and GCLM (show GCLM Proteins) can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC and GCLM (show GCLM Proteins) expression.

  3. Cigarette smoke-induced hypermethylation of the GCLC promoter is related to the initiation and progression of COPD (show ARCN1 Proteins).

  4. GCLC and GSS (show GSS Proteins) were expressed at higher levels in colon cancer tissue, as compared with normal mucosa.

  5. The Kaplan-Meier analysis shows that rs3736729 on GCLC presents a significant association with disease-free survival and overall survival.

  6. H2S upregulates GCLC and GSH and inhibits IL-1beta (show IL1B Proteins) levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis

  7. the CYP1A1 (rs2606345, rs4646903, rs1048943), GCLC, AGT, and AGTR1 genes was associated with pleuritis, empyema, acute respiratory distress syndrome, all PC and acute respiratory failure (ARF).

  8. A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.

  9. These data strongly indicate a discrepancy between the regulation of GCLC and of GGT following the oxidative stress situation due to mitochondrial uncoupling.

  10. 1,25 (OH) vitamin D significantly upregulated expression of GCLC and GR and lowered secretion of IL-8 (show IL8 Proteins) and MCP-1 (show CCL2 Proteins) in high-glucose exposed U937 monocytes.

Mouse (Murine) Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) interaction partners

  1. A floxed Gclc mouse was generated and crossed with a transgenic mouse expressing Cre in the lens to generate the Lens Glutathione Synthesis Knockout mouse in which de novo GSH synthesis was completely abolished in the lens.

  2. Clinically relevant levels of TGF-beta1 (show TGFB1 Proteins) suppresses GCLC and GCLM (show GCLM Proteins) expression in mouse lung.

  3. Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.

  4. The impacts of four clinical missense mutations on GCLC enzymatic function in vivo and in vitro, was evaluated.

  5. tBHQ has beneficial effects on reducing hyperglycemia-induced kidney injury, which is associated with the enhanced expression of Nrf2 (show NFE2L2 Proteins), and its downstream antioxidant HO-1 (show HMOX1 Proteins) and gamma-GCS (show UGCG Proteins) in the glomeruli of diabetic mice

  6. In first days of life luminescence measured was in all mice with distinct strain differences indicating NF-kappaB (show NFKB1 Proteins), superoxide dismutase (show SOD1 Proteins), gamma-glutamylcysteine synthetase, and antioxidant responsive element activity.

  7. Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (show GSS Proteins) (GS) (E.C. 6.3.2.3)

  8. activation of GSK-3beta is a key mediator of the initial phase of acetaminophen-induced liver injury through modulating GCL and Mcl-1 (show MCL1 Proteins) degradation, as well as JNK (show MAPK8 Proteins) activation in liver

  9. These findings demonstrate that TAT (show TAT Proteins)-mediated transduction of wild-type or dominant-inhibitory mutants of the Glutamate cysteine ligase (GCL) subunits is a viable means of manipulating cellular GCL activity.

  10. The GCLc protein was widely expressed throughout the embryo, and, in general, it co-localized with the Gclc mRNA.

Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC) Protein Profile

Protein Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Gene names and symbols associated with GCLC

  • glutamate-cysteine ligase, catalytic subunit (GCLC)
  • glutamate-cysteine ligase, catalytic subunit (gclc)
  • Glutamate-cysteine ligase catalytic subunit (Gclc)
  • gamma glutamylcysteine synthetase (LbGCS)
  • gamma glutamylcysteine synthetase (gcsA)
  • glutamate-cysteine ligase, catalytic subunit (LOC100049719)
  • gamma-glutamylcysteine synthetase (GSH1)
  • glutamate-cysteine ligase, catalytic subunit (Gclc)
  • 2259 protein
  • cb1049 protein
  • CG2259 protein
  • D9Wsu168e protein
  • DDBDRAFT_0186120 protein
  • DDBDRAFT_0231403 protein
  • DDB_0186120 protein
  • DDB_0231403 protein
  • Dmel\\CG2259 protein
  • DmGCLC protein
  • DmGCS protein
  • DmGCSh protein
  • fe36e11 protein
  • GCL protein
  • GCLc protein
  • GCS protein
  • Gcsh protein
  • Ggcs-hs protein
  • GLCL protein
  • GLCL-H protein
  • Glclc protein
  • MGC146287 protein
  • wu:fe36e11 protein

Protein level used designations for GCLC

glutamate--cysteine ligase catalytic subunit , glutamate-cysteine ligase, catalytic subunit , CG2259-PA , CG2259-PB , Gclc-PA , Gclc-PB , gamma-Glutamylcysteine synthetase , gamma-Glutamylcysteine synthetase catalytic subunit , gamma-glutamylcysteine ligase , glutamate cysteine ligase , glutamate-cysteine ligase , gamma glutamylcysteine synthetase , gamma-ECS , glutamate--cysteine ligase, chloroplastic , GCS heavy chain , gamma-glutamylcysteine synthetase , gamma GCS-HS , gamma-glutamylcysteine synthetase heavy subunit , Glutamylcysteine gamma synthetase light chain , glutamate-cysteine ligase catalytic subunit

GENE ID SPECIES
710508 Macaca mulatta
742732 Pan troglodytes
780264 Xenopus (Silurana) tropicalis
53581 Drosophila melanogaster
6073019 Laccaria bicolor S238N-H82
8624704 Dictyostelium discoideum AX4
100049719 Xenopus laevis
100137615 Xenopus laevis
543536 Solanum lycopersicum
2729 Homo sapiens
14629 Mus musculus
25283 Rattus norvegicus
326857 Danio rerio
609822 Canis lupus familiaris
512468 Bos taurus
421894 Gallus gallus
100726181 Cavia porcellus
100522018 Sus scrofa
100342383 Oryctolagus cuniculus
101114822 Ovis aries
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