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anti-Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) Antibodies

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Additionally we are shipping GCLM Kits (33) and GCLM Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GCLM 29739 P48508
GCLM 2730 P48507
GCLM 14630 O09172
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Top anti-GCLM Antibodies at antibodies-online.com

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-GCLM Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of GCLM Antibody (C-term) (ABIN653046) in 293 cell line and mouse kidney tissue lysates (35 µg/lane). GCLM (arrow) was detected using the purified polyclonal antibody. GCLM Antibody (C-term)(ABIN653046) IHC analysis in formalin fixed and paraffin embedded skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB Flow cytometric analysis of 293 cells using GCLM / GLCLR Antibody (C-term) Cat.-No AP51801PU-N(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of GCLM / GLCLR Antibody (C-term) Cat.-No AP51801PU-N with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Mouse Un-conjugated ELISA, WB GCLM monoclonal antibody (M01), clone 2B8 Western Blot analysis of GCLM expression in HeLa . Detection limit for recombinant GST tagged GCLM is approximately 1ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of GCLM staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of GCLM expression in SHSY5Y (A), HeLa (B), 3T3 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

GCLM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , , ,
,
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Mouse (Murine)


Top referenced anti-GCLM Antibodies

  1. Human Monoclonal GCLM Primary Antibody for ELISA, WB - ABIN516058 : Balamurugan, Akhov, Selvaraj, Pugazhenthi: Induction of antioxidant enzymes by curcumin and its analogues in human islets: implications in transplantation. in Pancreas 2009 (PubMed)
    Show all 4 references for ABIN516058

  2. Chicken Polyclonal GCLM Primary Antibody for IHC, WB - ABIN2785805 : Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. in International archives of occupational and environmental health 2008 (PubMed)
    Show all 2 references for ABIN2785805

  3. Human Polyclonal GCLM Primary Antibody for EIA, FACS - ABIN952478 : Moyer, Sun, Batzler, Li, Schaid, Yang, Weinshilboum: Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010 (PubMed)
    Show all 2 references for ABIN952478

  4. Human Monoclonal GCLM Primary Antibody for EIA, WB - ABIN1449395 : Inoue, Tomisawa, Yamazaki, Abe, Suemizu, Tsukamoto, Tomii, Kawamura, Kijima, Hatanaka, Ueyama, Nakamura, Kobayashi: The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer. in International journal of oncology 2003 (PubMed)
    Show all 2 references for ABIN1449395

More Antibodies against GCLM Interaction Partners

Human Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  2. Data suggest expression of hepatocyte GCLC (show GCLC Antibodies) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (show GCLC Antibodies) and GCLM expression.

  3. miR (show MLXIP Antibodies)-320a has a role in modulating the induction of HO-1 (show HMOX1 Antibodies), GCLM and OKL38 (show OSGIN1 Antibodies) by oxidized phospholipids in endothelial cells

  4. This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (show GCLC Antibodies).

  5. Knockdown of glutamate cysteine ligase catalytic subunit (show GCLC Antibodies) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.

  6. Upregulation of both GCLC (show GCLC Antibodies) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  7. Ten of the 17 maternal SNPs and 2 of the 17 fetal SNPs were found within the GCLM gene conotruncal heart defect (show Vcan Antibodies) cases.

  8. TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity

  9. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, GCLM-588 TT genotype individuals showed a lower risk than CC genotype; however, there were few TT carriers and the results were not statistically significant.

  10. GCLM is a functional target gene of the BACH1 (show BACH1 Antibodies) transcription factor according to ChIP-seq and knockdown analysis in HEK (show EPHA3 Antibodies) 293 cells.

Mouse (Murine) Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.

  2. Upregulation of both GCLC (show GCLC Antibodies) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  3. In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (show PVALB Antibodies) interneurons and have long-term consequences.

  4. Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (show PHB2 Antibodies).

  5. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

  6. Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.

  7. Clinically relevant levels of TGF-beta1 (show TGFB1 Antibodies) suppresses GCLC (show GCLC Antibodies) and GCLM expression in mouse lung.

  8. Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.

  9. Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.

  10. gclm KO mice showed a potentiated hyperlocomotor response to amphetamine, impaired sensorimotor gating, and altered social behavior compared to WT. These anomalies resemble important aspects of both SZ and the manic component of BP.

GCLM Antigen Profile

Protein Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene names and symbols associated with GCLM

  • glutamate-cysteine ligase regulatory subunit (PTRG_09814) antibody
  • glutamate cysteine ligase, modifier subunit (Gclm) antibody
  • glutamate cysteine ligase, modifier subunit-like (LOC100352174) antibody
  • glutamate-cysteine ligase, modifier subunit (gclm) antibody
  • glutamate-cysteine ligase, modifier subunit (GCLM) antibody
  • glutamate-cysteine ligase, modifier subunit (Gclm) antibody
  • Glutamate-cysteine ligase, modifier subunit (LOC100153977) antibody
  • AI649393 antibody
  • Gcmc antibody
  • GLCLR antibody
  • id:ibd3182 antibody
  • wu:fi24c07 antibody
  • zgc:55903 antibody

Protein level used designations for GCLM

glutamate-cysteine ligase regulatory subunit , GCS light chain , gamma-ECS regulatory subunit , gamma-glutamylcysteine synthetase regulatory subunit , glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory , glutamate--cysteine ligase regulatory subunit , glutamate-cysteine ligase modifier subunit , GSC light chain , glutamate--cysteine ligase modifier subunit , glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD) , glutamate-cysteine ligase modifier subunit delta2 alternative splicing , glutamate-cysteine ligase regulatory protein

GENE ID SPECIES
6348110 Pyrenophora tritici-repentis Pt-1C-BFP
29739 Rattus norvegicus
100352174 Oryctolagus cuniculus
333974 Danio rerio
380105 Xenopus laevis
424492 Gallus gallus
2730 Homo sapiens
525659 Bos taurus
14630 Mus musculus
100725164 Cavia porcellus
101117899 Ovis aries
100153977 Sus scrofa
Selected quality suppliers for anti-GCLM (GCLM) Antibodies
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