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Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) ELISA Kits

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Additionally we are shipping GCLM Antibodies (73) and GCLM Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GCLM 29739 P48508
GCLM 2730 P48507
GCLM 14630 O09172
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Top GCLM ELISA Kits at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.061 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$700.00
Details
Mouse 0.068 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$720.00
Details
Rat 0.052 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$760.00
Details
Mouse
  96 Tests Log in to see 8 to 9 Days
$680.63
Details
Pig
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Rabbit
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Chicken
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Monkey
  96 Tests Log in to see 8 to 9 Days
$770.00
Details
Human
  96 Tests Log in to see 11 to 13 Days
$785.71
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$785.71
Details

More ELISA Kits for GCLM Interaction Partners

Human Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  2. Data suggest expression of hepatocyte GCLC (show GCLC ELISA Kits) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (show GCLC ELISA Kits) and GCLM expression.

  3. miR (show MLXIP ELISA Kits)-320a has a role in modulating the induction of HO-1 (show HMOX1 ELISA Kits), GCLM and OKL38 (show OSGIN1 ELISA Kits) by oxidized phospholipids in endothelial cells

  4. This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (show GCLC ELISA Kits).

  5. Knockdown of glutamate cysteine ligase catalytic subunit (show GCLC ELISA Kits) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.

  6. Upregulation of both GCLC (show GCLC ELISA Kits) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  7. Ten of the 17 maternal SNPs and 2 of the 17 fetal SNPs were found within the GCLM gene conotruncal heart defect (show Vcan ELISA Kits) cases.

  8. TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity

  9. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, GCLM-588 TT genotype individuals showed a lower risk than CC genotype; however, there were few TT carriers and the results were not statistically significant.

  10. GCLM is a functional target gene of the BACH1 (show BACH1 ELISA Kits) transcription factor according to ChIP-seq and knockdown analysis in HEK (show EPHA3 ELISA Kits) 293 cells.

Mouse (Murine) Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.

  2. Upregulation of both GCLC (show GCLC ELISA Kits) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  3. In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (show PVALB ELISA Kits) interneurons and have long-term consequences.

  4. Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (show PHB2 ELISA Kits).

  5. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

  6. Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.

  7. Clinically relevant levels of TGF-beta1 (show TGFB1 ELISA Kits) suppresses GCLC (show GCLC ELISA Kits) and GCLM expression in mouse lung.

  8. Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.

  9. Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.

  10. gclm KO mice showed a potentiated hyperlocomotor response to amphetamine, impaired sensorimotor gating, and altered social behavior compared to WT. These anomalies resemble important aspects of both SZ and the manic component of BP.

GCLM Antigen Profile

Antigen Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene names and symbols associated with GCLM

  • glutamate-cysteine ligase regulatory subunit (PTRG_09814) antibody
  • glutamate cysteine ligase, modifier subunit (Gclm) antibody
  • glutamate cysteine ligase, modifier subunit-like (LOC100352174) antibody
  • glutamate-cysteine ligase, modifier subunit (gclm) antibody
  • glutamate-cysteine ligase, modifier subunit (GCLM) antibody
  • glutamate-cysteine ligase, modifier subunit (Gclm) antibody
  • Glutamate-cysteine ligase, modifier subunit (LOC100153977) antibody
  • AI649393 antibody
  • Gcmc antibody
  • GLCLR antibody
  • id:ibd3182 antibody
  • wu:fi24c07 antibody
  • zgc:55903 antibody

Protein level used designations for GCLM

glutamate-cysteine ligase regulatory subunit , GCS light chain , gamma-ECS regulatory subunit , gamma-glutamylcysteine synthetase regulatory subunit , glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory , glutamate--cysteine ligase regulatory subunit , glutamate-cysteine ligase modifier subunit , GSC light chain , glutamate--cysteine ligase modifier subunit , glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD) , glutamate-cysteine ligase modifier subunit delta2 alternative splicing , glutamate-cysteine ligase regulatory protein

GENE ID SPECIES
6348110 Pyrenophora tritici-repentis Pt-1C-BFP
29739 Rattus norvegicus
100352174 Oryctolagus cuniculus
333974 Danio rerio
380105 Xenopus laevis
424492 Gallus gallus
2730 Homo sapiens
525659 Bos taurus
14630 Mus musculus
100725164 Cavia porcellus
101117899 Ovis aries
100153977 Sus scrofa
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