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Glutamate-Cysteine Ligase, Modifier Subunit Proteins (GCLM)

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Additionally we are shipping GCLM Antibodies (100) and GCLM Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCLM 29739 P48508
GCLM 2730 P48507
GCLM 14630 O09172
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Top GCLM Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,715.17
Details
Human Un-conjugated 100 μg Log in to see 16 to 21 Days
$199.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GCLM Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
, ,
Mouse (Murine)

Top referenced GCLM Proteins

  1. Human GCLM Protein expressed in Escherichia coli (E. coli) - ABIN1098356 : Hanzawa, Ohnuma, Nagai, Shibata, Maeshima, Baba, Hatano, Takebayashi, Hotta, Kitazawa, Arai: No association between glutathione-synthesis-related genes and Japanese schizophrenia. in Psychiatry and clinical neurosciences 2011 (PubMed)

More Proteins for Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) Interaction Partners

Human Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (show HMOX1 Proteins)) and GCLM via activation of NRF2 (show GABPA Proteins)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.

  2. miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.

  3. Data suggest expression of hepatocyte GCLC (show GCLC Proteins) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (show GCLC Proteins) and GCLM expression.

  4. miR (show MLXIP Proteins)-320a has a role in modulating the induction of HO-1 (show HMOX1 Proteins), GCLM and OKL38 (show OSGIN1 Proteins) by oxidized phospholipids in endothelial cells

  5. This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (show GCLC Proteins).

  6. Knockdown of glutamate cysteine ligase catalytic subunit (show GCLC Proteins) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.

  7. Upregulation of both GCLC (show GCLC Proteins) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  8. Ten of the 17 maternal SNPs and 2 of the 17 fetal SNPs were found within the GCLM gene conotruncal heart defect (show Vcan Proteins) cases.

  9. TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity

  10. When eicosapentaenoic+docosahexaenoic acid or erythrocyte-mercury were divided into tertiles, GCLM-588 TT genotype individuals showed a lower risk than CC genotype; however, there were few TT carriers and the results were not statistically significant.

Mouse (Murine) Glutamate-Cysteine Ligase, Modifier Subunit (GCLM) interaction partners

  1. Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.

  2. Upregulation of both GCLC (show GCLC Proteins) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.

  3. In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (show PVALB Proteins) interneurons and have long-term consequences.

  4. Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (show PHB2 Proteins).

  5. The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.

  6. Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.

  7. Clinically relevant levels of TGF-beta1 (show TGFB1 Proteins) suppresses GCLC (show GCLC Proteins) and GCLM expression in mouse lung.

  8. Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.

  9. Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.

  10. gclm KO mice showed a potentiated hyperlocomotor response to amphetamine, impaired sensorimotor gating, and altered social behavior compared to WT. These anomalies resemble important aspects of both SZ and the manic component of BP.

GCLM Protein Profile

Protein Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene names and symbols associated with GCLM

  • glutamate-cysteine ligase regulatory subunit (PTRG_09814)
  • glutamate cysteine ligase, modifier subunit (Gclm)
  • glutamate cysteine ligase, modifier subunit-like (LOC100352174)
  • glutamate-cysteine ligase, modifier subunit (gclm)
  • glutamate-cysteine ligase, modifier subunit (GCLM)
  • glutamate-cysteine ligase, modifier subunit (Gclm)
  • Glutamate-cysteine ligase, modifier subunit (LOC100153977)
  • AI649393 protein
  • Gcmc protein
  • GLCLR protein
  • id:ibd3182 protein
  • wu:fi24c07 protein
  • zgc:55903 protein

Protein level used designations for GCLM

glutamate-cysteine ligase regulatory subunit , GCS light chain , gamma-ECS regulatory subunit , gamma-glutamylcysteine synthetase regulatory subunit , glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory , glutamate--cysteine ligase regulatory subunit , glutamate-cysteine ligase modifier subunit , GSC light chain , glutamate--cysteine ligase modifier subunit , glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD) , glutamate-cysteine ligase modifier subunit delta2 alternative splicing , glutamate-cysteine ligase regulatory protein

GENE ID SPECIES
6348110 Pyrenophora tritici-repentis Pt-1C-BFP
29739 Rattus norvegicus
100352174 Oryctolagus cuniculus
333974 Danio rerio
380105 Xenopus laevis
424492 Gallus gallus
2730 Homo sapiens
525659 Bos taurus
14630 Mus musculus
100725164 Cavia porcellus
101117899 Ovis aries
100153977 Sus scrofa
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