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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. Additionally we are shipping GCLM Antibodies (102) and GCLM Kits (42) and many more products for this protein.
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Glutaminolysis is activated in ES2 (show DGCR14 Proteins) and OVCAR3, though ES2 (show DGCR14 Proteins) exclusively synthesizes amino acids and GSH. ES2 (show DGCR14 Proteins) cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 (show DGCR14 Proteins) to carboplatin. HNF1beta (show HNF1B Proteins) regulates the expression of GCLC (show GCLC Proteins), but not GCLM, and consequently GSH production in ES2 (show DGCR14 Proteins)
Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (show HMOX1 Proteins)) and GCLM via activation of NRF2 (show GABPA Proteins)-ARE (nuclear factor erythroid 2-antioxidant response element) signaling.
miR-433 targets both catalytic (GCLc) and regulatory (GCLm) subunits of GCL.
Data suggest expression of hepatocyte GCLC (show GCLC Proteins) and GCLM can be regulated by dietary component; alpha-lipoic acid, a vitamin B complex nutrient, protects against oxidative stress/cytotoxicity induced by cadmium via restoration of GCLC (show GCLC Proteins) and GCLM expression.
miR (show MLXIP Proteins)-320a has a role in modulating the induction of HO-1 (show HMOX1 Proteins), GCLM and OKL38 (show OSGIN1 Proteins) by oxidized phospholipids in endothelial cells
This study demonstrated that Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase (show GCLC Proteins).
Knockdown of glutamate cysteine ligase catalytic subunit (show GCLC Proteins) by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.
Upregulation of both GCLC (show GCLC Proteins) and GLCM mRNA levels in response to cysteine deprivation was dependent on new protein synthesis.
Ten of the 17 maternal SNPs and 2 of the 17 fetal SNPs were found within the GCLM gene conotruncal heart defect (show Vcan Proteins) cases.
TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity
glutathione levels in the skin of Gclm knock-out mice are reduced by 70 %, which is sufficient for wound repair in young mice, but become rate-limiting upon aging
Gclm(-/-) mice have accelerated ovarian aging due to ovarian oxidative stress.
In Gclm KO mice, early-life insults inducing oxidative stress are detrimental to immature parvalbumin (show PVALB Proteins) interneurons and have long-term consequences.
Wild type female mice deficient in GSH due to deletion of Gclm were resistant to increase visceral adiposity and hepatic steatosis caused by exposure to the PAH BaP (show PHB2 Proteins).
The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.
Anxiety and drug-stimulated locomotor control brain regions are vulnerable to gclm/glutathione deficiencies.
Clinically relevant levels of TGF-beta1 (show TGFB1 Proteins) suppresses GCLC (show GCLC Proteins) and GCLM expression in mouse lung.
Genetic disruption of Gclm results in reduced aortic glutathione content and impaired acetylcholine mediated aortic ring relaxation.
Data suggest that Gclm is not involved in spermatogenesis but is involved in shielding testis/epididymis from oxidative stress; Gclm knockout mice are fertile but more sensitive to transplacental testicular/epididymal toxicity of benzo[a]pyrene.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.
glutamate-cysteine ligase regulatory subunit
, GCS light chain
, gamma-ECS regulatory subunit
, gamma-glutamylcysteine synthetase regulatory subunit
, glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
, glutamate--cysteine ligase regulatory subunit
, glutamate-cysteine ligase modifier subunit
, GSC light chain
, glutamate--cysteine ligase modifier subunit
, glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
, glutamate-cysteine ligase modifier subunit delta2 alternative splicing
, glutamate-cysteine ligase regulatory protein