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The protein encoded by GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Additionally we are shipping Glutaminase 2 (Liver, Mitochondrial) Kits (6) and Glutaminase 2 (Liver, Mitochondrial) Proteins (4) and many more products for this protein.
Showing 10 out of 49 products:
Human Polyclonal GLS2 Primary Antibody for ELISA, ICC - ABIN4314469
Gross, Demo, Dennison, Chen, Chernov-Rogan, Goyal, Janes, Laidig, Lewis, Li, Mackinnon, Parlati, Rodriguez, Shwonek, Sjogren, Stanton, Wang, Yang, Zhao, Bennett: Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. in Molecular cancer therapeutics 2014
Human Polyclonal GLS2 Primary Antibody for IHC (p), WB - ABIN652216
Shroff, Eberlin, Dang, Gouw, Gabay, Adam, Bellovin, Tran, Philbrick, Garcia-Ocana, Casey, Li, Dang, Zare, Felsher: MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. in Proceedings of the National Academy of Sciences of the United States of America 2015
Human Polyclonal GLS2 Primary Antibody for FACS, IHC - ABIN2437640
Shimmura, Suzuki, Iwata, Tsuchiya, Ohno, Matsuzaki, Iwata, Kameno, Takahashi, Wakuda, Nakamura, Hashimoto, Mori: Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism. in Molecular autism 2013
Chicken Polyclonal GLS2 Primary Antibody for IHC, WB - ABIN2781319
Toriumi, Mouri, Narusawa, Aoyama, Ikawa, Lu, Nagai, Mamiya, Kim, Nabeshima: Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012
As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1.
IDO (show IDO1 Antibodies), through GCN2 (show EIF2AK4 Antibodies) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Antibodies), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Antibodies) and GLS2
GABAergic neurons and astrocytes express Gls (show GLS Antibodies) and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons
Phosphate-activated glutaminase and GAD65 (show GAD2 Antibodies)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls
GLS2 expression is significantly decreased in hepatocellular carcinoma.
Silencing GLS (show GLS Antibodies) or overexpressing GLS2 induces growth inhibition in glioma cell lines.
GLS2 is acting, at least in part, downstream of p73 (show TP73 Antibodies) in neuronal differentiation and highlight a possible role of p73 (show TP73 Antibodies) in regulating neurotransmitter synthesis.
combination of negative modulation of glutaminase (show GLS Antibodies) isoforms arising from GLS (show GLS Antibodies) gene with the introduction of the GLS2 gene product, GAB (show A1BG Antibodies), may in the future provide a useful means to curb glioblastoma growth in situ
Epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers.
The present study was to investigate the potent effect of GLS2 on radioresistance of cervical carcinoma.
Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
Phosphate-activated glutaminase (GLS2) is a p53 (show TP53 Antibodies)-inducible regulator of glutamine (show GFPT1 Antibodies) metabolism and reactive oxygen species
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.
, L-glutamine amidohydrolase
, breast cell glutaminase
, glutaminase I
, glutaminase liver isoform, mitochondrial
, phosphate-activated glutaminase
, phosphate-dependent glutaminase
, liver mitochondrial glutaminase