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Glutaminase 2 (Liver, Mitochondrial) Proteins (GLS2)

The protein encoded by GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Additionally we are shipping Glutaminase 2 (Liver, Mitochondrial) Antibodies (47) and Glutaminase 2 (Liver, Mitochondrial) Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLS2 27165 Q9UI32
GLS2 216456 Q571F8
GLS2 192268 P28492
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Top Glutaminase 2 (Liver, Mitochondrial) Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,692.33
Details

GLS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Glutaminase 2 (Liver, Mitochondrial) (GLS2) Interaction Partners

Human Glutaminase 2 (Liver, Mitochondrial) (GLS2) interaction partners

  1. As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1.

  2. IDO (show IDO1 Proteins), through GCN2 (show EIF2AK4 Proteins) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2

  3. GABAergic neurons and astrocytes express Gls (show GLS Proteins) and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons

  4. Phosphate-activated glutaminase and GAD65 (show GAD2 Proteins)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls

  5. GLS2 expression is significantly decreased in hepatocellular carcinoma.

  6. Silencing GLS (show GLS Proteins) or overexpressing GLS2 induces growth inhibition in glioma cell lines.

  7. GLS2 is acting, at least in part, downstream of p73 (show TP73 Proteins) in neuronal differentiation and highlight a possible role of p73 (show TP73 Proteins) in regulating neurotransmitter synthesis.

  8. combination of negative modulation of glutaminase (show GLS Proteins) isoforms arising from GLS (show GLS Proteins) gene with the introduction of the GLS2 gene product, GAB (show A1BG Proteins), may in the future provide a useful means to curb glioblastoma growth in situ

  9. Epigenetic silencing of Gls2 via promoter hypermethylation is common in human liver and colon cancers.

  10. The present study was to investigate the potent effect of GLS2 on radioresistance of cervical carcinoma.

Mouse (Murine) Glutaminase 2 (Liver, Mitochondrial) (GLS2) interaction partners

  1. Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.

  2. Phosphate-activated glutaminase (GLS2) is a p53 (show TP53 Proteins)-inducible regulator of glutamine (show GFPT1 Proteins) metabolism and reactive oxygen species

Glutaminase 2 (Liver, Mitochondrial) (GLS2) Protein Profile

Protein Summary

The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.

Gene names and symbols associated with GLS2

  • glutaminase 2 (glsA2)
  • glutaminase 2 (LOAG_03311)
  • glutaminase 2 (liver, mitochondrial) (gls2)
  • glutaminase 2 (liver, mitochondrial) (GLS2)
  • glutaminase 2 (liver, mitochondrial) (Gls2)
  • A330074B06Rik protein
  • AI195532 protein
  • Ga protein
  • GLS protein
  • hLGA protein
  • Lga protein
  • si:ch211-216k22.10 protein

Protein level used designations for GLS2

glutaminase 2 , L-glutamine amidohydrolase , breast cell glutaminase , glutaminase I , glutaminase liver isoform, mitochondrial , phosphate-activated glutaminase , phosphate-dependent glutaminase , L-glutaminase , liver mitochondrial glutaminase , GLS

GENE ID SPECIES
8710836 Citrobacter rodentium ICC168
9940699 Loa loa
100006303 Danio rerio
27165 Homo sapiens
100686499 Canis lupus familiaris
539561 Bos taurus
216456 Mus musculus
192268 Rattus norvegicus
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