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GFPT1 encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. Additionally we are shipping Glutamine--Fructose-6-Phosphate Transaminase 1 Proteins (7) and Glutamine--Fructose-6-Phosphate Transaminase 1 Kits (3) and many more products for this protein.
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GFAT-1 plays a critical role in modulating adipogenesis
3'-UTR (show UTS2R Antibodies) mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome
Two GFPT1 untranslated mutations may cause limb-girdle myasthenia by reducing GFPT1 expression and ultimately impairing protein glycosylation.
Inhibition of GFPT1 enzymatic activity or siRNA silencing of GFPT1 expression resulted in reduced AChR expression.
The results found no correlation between end plate morphology and physiology or between genotype and phenotype in GFPT1-myasthenia.
GFPT1 is the key enzyme in the hexosamine biosynthesis pathway. Mutations in GFPT1 cause defective glycosylation in the proteins of the neuromuscular junction.
Downregulation of the GFPT1 is associated with neuromuscular transmission defect.
An increased concentration of wild-type GFAT in mesangial cells is enhanced both TGF-beta1 (show TGFB1 Antibodies) and fibronectin (show FN1 Antibodies)
Genetic variation in GFPT1 is unlikely to have a major impact on susceptibility to diabetic nephropathy.
Variants in the GFPT1 gene show suggestive evidence of an association with diabetic nephropathy among African-American individuals, and increased GFPT1 gene expression may characterize Caucasian subjects with diabetic nephropathy.
On the basis of the docking results, a binding pocket of human GFAT1 dimer for UDP-GlcNAc (show B3GNT3 Antibodies) is defined.
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Gfpt, Oga (O-GlcNAcase), and Ogt (O-GlcNAc transferase).
cDNA sequence of the porcine GFAT1 gene was cloned and a GFAT1 splice variant (designed GFAT1-L) that contains a 54 bp insertion within the coding region, was identified.
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate.
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine-fructose-6-phosphate transaminase 1
, glutamine--fructose-6-phosphate transaminase 1
, D-fructose-6-phosphate amidotransferase 1
, GFAT 1
, glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine:fructose 6 phosphate amidotransferase 1
, glutamine:fructose-6-phosphate amidotransferase 1
, hexosephosphate aminotransferase 1
, glutamine fructose aminotransferase
, glutamine-fructose-6-phosphate aminotransferase 1