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anti-Glutaminyl-Peptide Cyclotransferase (QPCT) Antibodies

QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Proteins (13) and QPCT Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
QPCT 25797 Q16769
QPCT 83621  
QPCT 70536 Q9CYK2
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Top anti-QPCT Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged QPCT is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.89 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB QPCT Antibody (C-term)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the QPCT antibody detected the QPCT protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB QPCT MaxPab polyclonal antibody. Western Blot analysis of QPCT expression in HeLa. Western Blot analysis of QPCT expression in transfected 293T cell line by QPCT MaxPab polyclonal antibody.Lane 1: QPCT transfected lysate(39.71 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated IHC (p), ELISA 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IP, WB QPCT MaxPab rabbit polyclonal antibody. Western Blot analysis of QPCT expression in HeLa. Immunoprecipitation of QPCT transfected lysate using anti-QPCT MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with QPCT purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 9 Days
$418.57
Details

QPCT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
,
,
, , , , ,
Rat (Rattus)


Mouse (Murine)


Top referenced anti-QPCT Antibodies

  1. Human Monoclonal QPCT Primary Antibody for ELISA, WB - ABIN394702 : Marroni, Pfeufer, Aulchenko, Franklin, Isaacs, Pichler, Wild, Oostra, Wright, Campbell, Witteman, Kääb, Hicks, Gyllensten, Rudan, Meitinger, Pattaro, van Duijn, Wilson, Pramstaller: A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. in Circulation. Cardiovascular genetics 2009 (PubMed)
    Show all 5 references for ABIN394702

  2. Human Polyclonal QPCT Primary Antibody for ELISA, WB - ABIN565166 : Morawski, Hartlage-Rübsamen, Jäger, Waniek, Schilling, Schwab, McGeer, Arendt, Demuth, Rossner: Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. in Acta neuropathologica 2010 (PubMed)
    Show all 4 references for ABIN565166

  3. Human Polyclonal QPCT Primary Antibody for WB - ABIN2565834 : Morawski, Schilling, Kreuzberger, Waniek, Jäger, Koch, Cynis, Kehlen, Arendt, Hartlage-Rübsamen, Demuth, Roßner: Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2014 (PubMed)

  4. Chicken Polyclonal QPCT Primary Antibody for WB - ABIN2783489 : Cynis, Rahfeld, Stephan, Kehlen, Koch, Wermann, Demuth, Schilling: Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery. in Journal of molecular biology 2008 (PubMed)

More Antibodies against QPCT Interaction Partners

Human Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP Antibodies) formation

  2. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.

  3. Upregulation of QPCT expression is associated with thyroid carcinomas.

  4. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP Antibodies) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.

  5. Upon binding to PBD150, a large loop movement in gQC (show QPCTL Antibodies) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.

  6. This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP Antibodies) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.

  7. Human isoQC (show QPCTL Antibodies)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  8. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.

  9. human glutaminyl cyclase is a metal-dependent transferase

  10. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively

Mouse (Murine) Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.

  2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH Antibodies) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP Antibodies) deposits

  3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL Antibodies) in defined brain regions of different inbred and outbred mouse strains

  4. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism

  5. Murine isoQC (show QPCTL Antibodies) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  6. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.

  7. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE Antibodies), cathepsin B (show CTSB Antibodies), and glutaminyl cyclase.

QPCT Antigen Profile

Protein Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Gene names and symbols associated with QPCT

  • glutaminyl-peptide cyclotransferase (QPCT) antibody
  • glutaminyl-peptide cyclotransferase (M6_Spy0443) antibody
  • glutaminyl-peptide cyclotransferase (M5005_Spy_0416) antibody
  • glutaminyl-peptide cyclotransferase (M28_Spy0404) antibody
  • glutaminyl-peptide cyclotransferase (CJA_2408) antibody
  • glutaminyl-peptide cyclotransferase (CCNA_02733) antibody
  • glutaminyl-peptide cyclotransferase (Tsp_03182) antibody
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (LOC100217805) antibody
  • glutaminyl-peptide cyclotransferase (Qpct) antibody
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct) antibody
  • 5730422A13Rik antibody
  • GCT antibody
  • QC antibody
  • QPCT antibody
  • sQC antibody

Protein level used designations for QPCT

glutaminyl-peptide cyclotransferase , glutaminyl-peptide cyclotransferase (glutaminyl cyclase) , EC , glutaminyl cyclase , glutaminyl-tRNA cyclotransferase , glutamyl cyclase , QC

GENE ID SPECIES
744549 Pan troglodytes
2942628 Streptococcus pyogenes MGAS10394
3572510 Streptococcus pyogenes MGAS5005
3574689 Streptococcus pyogenes MGAS6180
6415865 Cellvibrio japonicus Ueda107
7330894 Caulobacter crescentus NA1000
10908433 Trichinella spiralis
100217805 Taeniopygia guttata
421479 Gallus gallus
25797 Homo sapiens
403861 Canis lupus familiaris
397424 Sus scrofa
281437 Bos taurus
83621 Rattus norvegicus
70536 Mus musculus
Selected quality suppliers for anti-QPCT (QPCT) Antibodies
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