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QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Antibodies (57) and QPCT Proteins (13) and many more products for this protein.
Showing 3 out of 8 products:
Human QPCT ELISA Kit for Sandwich ELISA - ABIN422885
Valenti, Bolognin, Zanatta, Donatelli, Innamorati, Pampanin, Zanusso, Zatta, Dalle Carbonare: Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. in Journal of Alzheimer's disease : JAD 2013
observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP ELISA Kits) formation
this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.
Upregulation of QPCT expression is associated with thyroid carcinomas.
The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP ELISA Kits) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.
Upon binding to PBD150, a large loop movement in gQC (show QPCTL ELISA Kits) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.
This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP ELISA Kits) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.
Human isoQC (show QPCTL ELISA Kits)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.
human glutaminyl cyclase is a metal-dependent transferase
Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively
Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.
co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH ELISA Kits) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP ELISA Kits) deposits
This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL ELISA Kits) in defined brain regions of different inbred and outbred mouse strains
Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism
Murine isoQC (show QPCTL ELISA Kits) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.
The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE ELISA Kits), cathepsin B (show CTSB ELISA Kits), and glutaminyl cyclase.
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
, glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
, glutaminyl cyclase
, glutaminyl-tRNA cyclotransferase
, glutamyl cyclase