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Glutaminyl-Peptide Cyclotransferase (QPCT) ELISA Kits

QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Antibodies (57) and QPCT Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
QPCT 25797 Q16769
Anti-Rat QPCT QPCT 83621  
QPCT 70536 Q9CYK2
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Top QPCT ELISA Kits at antibodies-online.com

Showing 3 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.064 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$736.84
Details
Mouse
  96 Tests Log in to see 11 to 13 Days
$875.60
Details
Cow
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

Top referenced QPCT ELISA Kits

  1. Human QPCT ELISA Kit for Sandwich ELISA - ABIN422885 : Valenti, Bolognin, Zanatta, Donatelli, Innamorati, Pampanin, Zanusso, Zatta, Dalle Carbonare: Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. in Journal of Alzheimer's disease : JAD 2013 (PubMed)

More ELISA Kits for QPCT Interaction Partners

Human Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP ELISA Kits) formation

  2. this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.

  3. Upregulation of QPCT expression is associated with thyroid carcinomas.

  4. The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP ELISA Kits) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.

  5. Upon binding to PBD150, a large loop movement in gQC (show QPCTL ELISA Kits) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.

  6. This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP ELISA Kits) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.

  7. Human isoQC (show QPCTL ELISA Kits)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  8. Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.

  9. human glutaminyl cyclase is a metal-dependent transferase

  10. Glutaminyl cyclase was expressed as a fully active 37 kDa enzyme with kcat/Km values of 14.3, 9.3, and 2.4 mM(-1)s(-1) for the substrates Gln-Gln, Gln-NH(2), and Gln-t-butyl ester, respectively

Mouse (Murine) Glutaminyl-Peptide Cyclotransferase (QPCT) interaction partners

  1. Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.

  2. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH ELISA Kits) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP ELISA Kits) deposits

  3. This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL ELISA Kits) in defined brain regions of different inbred and outbred mouse strains

  4. Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism

  5. Murine isoQC (show QPCTL ELISA Kits) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.

  6. Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.

  7. The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE ELISA Kits), cathepsin B (show CTSB ELISA Kits), and glutaminyl cyclase.

QPCT Antigen Profile

Antigen Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.

Gene names and symbols associated with QPCT

  • glutaminyl-peptide cyclotransferase (QPCT) antibody
  • glutaminyl-peptide cyclotransferase (M6_Spy0443) antibody
  • glutaminyl-peptide cyclotransferase (M5005_Spy_0416) antibody
  • glutaminyl-peptide cyclotransferase (M28_Spy0404) antibody
  • glutaminyl-peptide cyclotransferase (CJA_2408) antibody
  • glutaminyl-peptide cyclotransferase (CCNA_02733) antibody
  • glutaminyl-peptide cyclotransferase (Tsp_03182) antibody
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (LOC100217805) antibody
  • glutaminyl-peptide cyclotransferase (Qpct) antibody
  • glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct) antibody
  • 5730422A13Rik antibody
  • GCT antibody
  • QC antibody
  • QPCT antibody
  • sQC antibody

Protein level used designations for QPCT

glutaminyl-peptide cyclotransferase , glutaminyl-peptide cyclotransferase (glutaminyl cyclase) , EC , glutaminyl cyclase , glutaminyl-tRNA cyclotransferase , glutamyl cyclase , QC

GENE ID SPECIES
744549 Pan troglodytes
2942628 Streptococcus pyogenes MGAS10394
3572510 Streptococcus pyogenes MGAS5005
3574689 Streptococcus pyogenes MGAS6180
6415865 Cellvibrio japonicus Ueda107
7330894 Caulobacter crescentus NA1000
10908433 Trichinella spiralis
100217805 Taeniopygia guttata
421479 Gallus gallus
25797 Homo sapiens
403861 Canis lupus familiaris
397424 Sus scrofa
281437 Bos taurus
83621 Rattus norvegicus
70536 Mus musculus
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