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Glutaredoxin 2 Proteins (GRX2)

The protein encoded by GRX2 is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. Additionally we are shipping Glutaredoxin 2 Antibodies (44) and Glutaredoxin 2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRX2 51022 Q9NS18
Rat GRX2 GRX2 114022 Q6AXW1
GRX2 69367 Q923X4
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Top Glutaredoxin 2 Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,200.00
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,297.17
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,306.33
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Yeast Un-conjugated   10 μg Log in to see 6 to 11 Days
$142.86
Details

GRX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Glutaredoxin 2 Proteins

  1. Human Glutaredoxin 2 Protein expressed in Escherichia coli (E. coli) - ABIN666919 : Nagy, Malik, Tosaki, Ho, Maulik, Das: Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis. in Journal of molecular and cellular cardiology 2008 (PubMed)
    Show all 2 references for ABIN666919

More Proteins for Glutaredoxin 2 (GRX2) Interaction Partners

Human Glutaredoxin 2 (GRX2) interaction partners

  1. Grx2 and Trx1 (show MLL Proteins) contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders.

  2. The Grx2 system could help to keep Trx2 (show TXN2 Proteins)/1 reduced during an oxidative stress, thereby contributing to the anti-apoptotic signaling.

  3. Grx2 thiol redox regulation is essential for vertebrate embryonic development

  4. Exchange of [2Fe-2S] centers between glutaredoxin 2 and the cluster scaffold protein (show HOMER1 Proteins) ISU, supports a direct link for glutaredoxin 2 and glutathione involvement in ISU promoted Fe-S cluster biosynthesis.

  5. Both thioredoxin 2 (show TXN2 Proteins) and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys (show DNAJC5 Proteins) peroxiredoxin Prx3 (show PRDX3 Proteins).

  6. Studies indicate that the mechanism of Grx2 protection against H(2)O(2)-induced apoptosis is likely associated with its ability to preserve complex I.

  7. results suggest an important role for glutaredoxin 2 in protection and recovery from oxidative stress

  8. Grx1 (show GRX1 Proteins) and Grx2 were present in placenta extracts and in cell lysates prepared from tumor cell lines; however, the levels of Grx1 (show GRX1 Proteins) were at least 20 times higher than those of Grx2; Grx2 was not detected in plasma from healthy blood donors

  9. Lung cells can synthesize Grx2 mRNA and protein.

  10. characterization of Grx2 as an iron-sulfur center-containing member of the thioredoxin (show TXN Proteins) fold protein family

Mouse (Murine) Glutaredoxin 2 (GRX2) interaction partners

  1. Increasing Grx2a activity in macrophage mitochondria disrupts mitochondrial respiration and ATP production, but without affecting the proatherogenic potential of macrophages from LDL receptor (show LDLR Proteins) knockout mice.

  2. Grx2 gene deletion altered the function of lens structural proteins through S-glutathionylation and also caused severe disturbance in mitochondrial function.

  3. The results suggest that Glrx2b enhances RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis via p38 (show CRK Proteins) activation.

  4. Data indicate that glutaredoxin-2 (Grx2) plays a vital role in modulating mitochondrial metabolism in cardiac muscle, and Grx2 deficiency leads to pathology.

  5. Grx2 deactivates UCP3 by glutathionylation.

  6. Grx2 has a function that protects cells against H(2)O(2)-induced injury via its peroxidase and dethiolase activities; particularly, Grx2 prevents complex I inactivation and preserves mitochondrial function.

  7. Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2, Prx3 (show PRDX3 Proteins), and Prx6 (show PRDX6 Proteins) were highly expressed in proximal tubule cells

  8. Both thioredoxin 2 (show TXN2 Proteins) and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys (show DNAJC5 Proteins) peroxiredoxin Prx3 (show PRDX3 Proteins).

  9. Data indicate that glutaredoxin 2 plays a central role in the response of mitochondria to both redox signals and oxidative stress by facilitating the interplay between the mitochondrial glutathione pool and protein thiols.

  10. Glutaredoxin-2 expression increased in a murine model of high-fat diet-induced atherogenesis.

Glutaredoxin 2 (GRX2) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression.

Gene names and symbols associated with Glutaredoxin 2 Proteins (GRX2)

  • glutaredoxin 2 (Grx2) (grxB)
  • glutaredoxin Grx2 (grx2)
  • glutaredoxin (grx-2) (grx-2)
  • glutaredoxin 2 (GLRX2)
  • glutaredoxin 2 (Glrx2)
  • glutaredoxin 2 (thioltransferase) (Glrx2)
  • 1700010P22Rik protein
  • AI645710 protein
  • CGI-133 protein
  • ECK1049 protein
  • Grx2 protein
  • JW1051 protein

Protein level used designations for Glutaredoxin 2 Proteins (GRX2)

glutaredoxin 2 (Grx2) , glutaredoxin Grx2 , glutaredoxin (grx-2) , bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) , glutaredoxin 2 (thioltransferase) , glutaredoxin-2, mitochondrial

GENE ID SPECIES
7955106 Escherichia coli BW2952
8215931 Escherichia coli O157:H7 str. TW14359
946926 Escherichia coli str. K-12 substr. MG1655
8183352 Escherichia coli BL21(DE3)
8175830 Escherichia coli B str. REL606
2542807 Schizosaccharomyces pombe 972h-
1485374 Archaeoglobus fulgidus DSM 4304
51022 Homo sapiens
114022 Rattus norvegicus
513762 Bos taurus
100172258 Pongo abelii
478956 Canis lupus familiaris
69367 Mus musculus
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