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Glutathione Peroxidase 4 Proteins (GPX4)

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Additionally we are shipping GPX4 Antibodies (91) and GPX4 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPX4 2879 P36969
GPX4 625249 O70325,Q91XR9
GPX4 29328 P36970,Q91XR8
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Top GPX4 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 5 to 8 Days
$299.25
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$823.90
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,651.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.5 mg Log in to see 11 to 16 Days
$555.13
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   500 μg Log in to see 3 to 4 Days
$328.21
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details

GPX4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for Glutathione Peroxidase 4 (GPX4) Interaction Partners

Zebrafish Glutathione Peroxidase 4 (GPX4) interaction partners

  1. We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.

Human Glutathione Peroxidase 4 (GPX4) interaction partners

  1. use GPX4 and GPX7 (show GPX7 Proteins) as possible markers for improving HCC (show FAM126A Proteins) diagnosis/prognosis.

  2. One SNP (rs3746162) in GPX4 was significantly associated with bladder cancer recurrence after transurethral resection.

  3. Hepatitis C virus (HCV) induces oxidative stress but controls it tightly by inducing ROS (show ROS1 Proteins) scavengers. Among these, GPx4 plays an essential role in the HCV life cycle.

  4. GPX1 (show GPX1 Proteins), GPX3 (show GPX3 Proteins), and GPX4 genes may play a role in clear cell renal cell carcinoma (show MOK Proteins) cancerogenesis.

  5. polymorphism of gene of glutathione peroxidase (show GPX1 Proteins) predisposes to more severe affection of liver and progression of chronic hepatitis C.

  6. GPx4 is essential for maintaining oxidative homeostasis and keeping defense against oxidative stress in conjunctival epithelial cells.

  7. Identification of truncating mutations in GPX4 in two families affected with Sedaghatian-type spondylometaphyseal dysplasia.

  8. A membrane glycoprotein (show CD86 Proteins) GPX4 was shown to play a significant role in gamete interactions.

  9. Erythrocyte glutathione peroxidase (show GPX1 Proteins) activity is modified by single nucleotide polymorphisms in SEPP1 (show SEPP1 Proteins), GPX4 and GPX1 (show GPX1 Proteins) and by estrogens.

  10. neither CYBB (show CYBB Proteins) nor GPX4 are major genetic determinants of diabetic nephropathy, but nevertheless, they could modulate in a gender-specific manner the risk for renal disease in patients with type 1 diabetes.

Mouse (Murine) Glutathione Peroxidase 4 (GPX4) interaction partners

  1. Phospholipid hydroperoxide glutathione peroxidase (show GPX1 Proteins) is involved in the maintenance of male fertility under cryptorchidism in mice

  2. dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo

  3. The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice.

  4. Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice.

  5. GPx4 suppresses the increase in the VEGF-A (show VEGFA Proteins) protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV.

  6. Inducible disruption of Gpx4 causes acute renal failure and early death in an Alox15 (show ALOX15 Proteins)-independent manner

  7. A membrane glycoprotein (show CD86 Proteins) GPX4 was shown to play a significant role in gamete interactions.

  8. Rat Gpx4 is a moonlighting protein that functions both as a peroxidase, as well as a structural protein.

  9. GPx4-overexpressing mice showed no free fatty acid induced increase in reactive oxygen species and lipid peroxidation

  10. Activity of cutaneous GPx4 is linked to the regulation of COX-2 and hair follicle morphogenesis and provides insight into the function of individual selenoprotein activity in maintaining cutaneous homeostasis.

Cow (Bovine) Glutathione Peroxidase 4 (GPX4) interaction partners

  1. GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen

GPX4 Protein Profile

Protein Summary

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.

Gene names and symbols associated with GPX4

  • glutathione peroxidase 4a (gpx4a)
  • glutathione peroxidase 4 (GPX4)
  • glutathione peroxidase 4 (Gpx4)
  • 1700027O09Rik protein
  • cb563 protein
  • cb691 protein
  • GP-GPx4 protein
  • gpx-4 protein
  • GSHPx-4 protein
  • MCSP protein
  • mtPHGPx protein
  • Phgpx protein
  • PHGPxa protein
  • sb:cb563 protein
  • snGpx protein
  • snPHGPx protein
  • wu:fb82e03 protein
  • zgc:92253 protein

Protein level used designations for GPX4

glutathione peroxidase 4 , phospholipid hydroperoxidase , phospholipid hydroperoxide glutathione peroxidase, mitochondrial , sperm nucleus glutathione peroxidase , GPx-4 , GSHPx-4 , phospholipid hydroperoxide glutathione peroxidase, nuclear , sperm nuclei glutathione peroxidase , phospholipid hydroperoxide glutathione peroxidase , glutathione peroxidase 4 (phospholipid hydroperoxidase)

GENE ID SPECIES
352928 Danio rerio
2879 Homo sapiens
625249 Mus musculus
29328 Rattus norvegicus
100730119 Cavia porcellus
399537 Sus scrofa
286809 Bos taurus
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