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Glutathione S-Transferase alpha 4 Proteins (GSTA4)

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Additionally we are shipping Glutathione S-Transferase alpha 4 Antibodies (72) and Glutathione S-Transferase alpha 4 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GSTA4 300850 P14942
GSTA4 2941 O15217
GSTA4 14860 P24472
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Top Glutathione S-Transferase alpha 4 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,553.83
Details

GSTA4 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
,
Human , ,
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Mouse (Murine)

Top referenced Glutathione S-Transferase alpha 4 Proteins

  1. Human GSTA4 Protein expressed in Escherichia coli (E. coli) - ABIN1098254 : Balogh, Le Trong, Kripps, Shireman, Stenkamp, Zhang, Mannervik, Atkins: Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. in Biochemistry 2010 (PubMed)
    Show all 2 references for ABIN1098254

More Proteins for Glutathione S-Transferase alpha 4 (GSTA4) Interaction Partners

Human Glutathione S-Transferase alpha 4 (GSTA4) interaction partners

  1. Decreased gene expression of GSTA4 is associated with drug resistance in cervical cancer.

  2. Data indicate that steroidogenic factor 1 (SF-1 (show NR5A1 Proteins)) and glutathione S-transferase A (GSTA (show GSTa2 Proteins)) family genes (hGSTA1-hGSTA4) are involved in steroidogenesis.

  3. GSTA4 down-regulation and the concomitant increase in 4-hydroxynonenal adducts in muscle are indicative of susceptibility to infection in individuals with severe thermal injuries.

  4. Data show that mandatory overexpression of hGSTA4 by transient transfection in KYSE30 cells and attenuation of HNE (show ELANE Proteins)-induced EGFR (show EGFR Proteins) phosphorylation.

  5. analysis of four novel mutations that change the function of leukotriene C(4) synthase (show LTC4S Proteins) and are associated with increased risk of venous thromboembolism and ischemic stroke

  6. Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.

  7. Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS (show ROS1 Proteins) production, and mitochondrial dysfunction and may contribute to the development of insulin (show INS Proteins) resistance and type 2 diabetes.

  8. GSTA4-4 exploits the hydroxyl group of either 4R- or 4S-hydroxynonenal (HNE (show ELANE Proteins)), while specifically binding HNE (show ELANE Proteins) and glutathione (GSH) to maintain high catalytic efficiency linked with stereoselective product formation for both enantiomeric substrates.

  9. null mice had a significantly lower survival time than wild-type controls when chronically treated with relatively low doses of paraquat, a finding consistent with a role of glutathione transferase A4-4 in the defense against oxidative stress

  10. we observed a single nucleotide polymorphism (SNP) G351A leading to the silent mutation Gln117Gln.No significant difference was observed in the distribution of this GSTA4 polymorphism between Parkinson disease individuals and healthy controls

Mouse (Murine) Glutathione S-Transferase alpha 4 (GSTA4) interaction partners

  1. Data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins.

  2. although loss of GSTA4-4 led to enhanced susceptibility of cardiac mitochondria to radiation-induced loss of morphology, cardiac function was preserved in Gsta4-null mice

  3. These results indicate that 4-HNE (show ELANE Proteins) significantly contributes to the mechanisms of tubule injury and fibrosis and that these effects can be inhibited by the enhanced expression of GSTA4-4.

  4. In the absence of GSTA4-4 to modulate both physiological and pathological 4-hydroxynonenal (HNE (show ELANE Proteins)) levels, the adaptive NRF (show NKRF Proteins)-E2-related (Nrf)2 (show NFE2L2 Proteins) factor pathway may be primed to contribute to a preconditioned cardiac phenotype in the Gsta4-null mouse.

  5. The naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI (show TBPL1 Proteins). Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI (show TBPL1 Proteins).

  6. 2-APB (show RNPEP Proteins) treatment restrained nasal lavage fluid LTC4, ECP (show ECP Proteins), ovalbumin (show OVA Proteins)-specific IgE, and IL-4 (show IL4 Proteins) and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones.

  7. Gsta4/GSTA4 is a novel susceptibility gene for NMSC that affects risk in both mice and humans.

  8. Results indicate that downregulation of GSTA4 in adipose tissue leads to increased protein carbonylation, ROS (show ROS1 Proteins) production, and mitochondrial dysfunction and may contribute to the development of insulin (show INS Proteins) resistance and type 2 diabetes.

  9. mGsta4-null mice, in which 4-HNE (show ELANE Proteins) detoxification is impaired, have an extended life span.

  10. in regenerating hepatocytes, several GST isoforms are induced and that cytokines TNFalpha (show TNF Proteins) and IL-6 (show IL6 Proteins) and survival factor EGF (show EGF Proteins) positively regulate mGSTA4 via survival signaling pathways.

Glutathione S-Transferase alpha 4 (GSTA4) Protein Profile

Protein Summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.

Gene names and symbols associated with GSTA4

  • glutathione S-transferase alpha 4 (GSTA4)
  • glutathione S-transferase alpha 4 (gsta4)
  • glutathione S-transferase alpha 4 (Gsta4)
  • glutathione S-transferase alpha 4 (LOC100341622)
  • glutathione S-transferase mu 2 (Gstm2)
  • glutathione S-transferase, alpha 3 (GSTA3)
  • glutathione S-transferase, alpha 4 (Gsta4)
  • GST5.7 protein
  • GSTA4 protein
  • GSTA4-4 protein
  • GTA4 protein
  • mGsta4 protein
  • tGSTA4 protein

Protein level used designations for GSTA4

glutathione S-transferase A4 , glutathione S-transferase alpha class A4 , GST 8-8 , GST A4-4 , GST K , GST Yk , glutathione S-transferase Yk , glutathione S-transferase alpha-4 , glutathione transferase , GST class-alpha member 4 , S-(hydroxyalkyl)glutathione lyase A4 , glutathione S-alkyltransferase A4 , glutathione S-aralkyltransferase A4 , glutathione S-aryltransferase A4 , glutathione S-transferase A4-4 , glutathione transferase A4-4 , GST 4-4 , GST Yb2 , GSTM2-2 , Glutathione-S-transferase mu type 2 (Yb2) , Glutathione-S-transferase, mu type 2 (Yb2) , glutathione S-transferase M2 , glutathione S-transferase Mu 2 , glutathione S-transferase Yb-2 , glutathione S-transferase Yb2 subunit , GSTA4-4 , glutathione S-transferase 5.7

GENE ID SPECIES
462771 Pan troglodytes
549430 Xenopus (Silurana) tropicalis
734548 Xenopus laevis
100379163 Meleagris gallopavo
300850 Rattus norvegicus
2941 Homo sapiens
474939 Canis lupus familiaris
533917 Bos taurus
100152951 Sus scrofa
100341622 Oryctolagus cuniculus
24424 Rattus norvegicus
768055 Bos taurus
14860 Mus musculus
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