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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Additionally we are shipping GSTM4 Antibodies (36) and GSTM4 Proteins (15) and many more products for this protein.
Our data suggest that the combined treatment with chemotherapy and GST(GSTM1 (show GSTM1 ELISA Kits), GSTM4 and GSTT1 (show GSTT1 ELISA Kits) ) inhibitors such as EA might be an interesting option for patients with chemoresistant Hodgkin's lymphoma
There were no significant associations between glutathione-S-transferases and p53 (show TP53 ELISA Kits) expressions and tumor stage, tumor grade and smoking status (p>0.05).
We observed suggestive associations between survival and GSTT1 (show GSTT1 ELISA Kits) copy number and GSTA5 (show GSTa5 ELISA Kits), GSTM4, and ABCC4 (show ABCC4 ELISA Kits) single nucleotide polymorphisms
A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer.
a novel splice variant of GSTM4 that resulted from tandem skipping of exons 4 and 5 is identified.
GSTM4 (glutathione S-transferase mu 4) haplotype 1101000 may be an important determinant for lung function growth
GSTM4 contributes to the cancerous behavior of Ewing's sarcoma.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
glutathione S-transferase M4
, GST class-mu 4
, S-(hydroxyalkyl)glutathione lyase M4
, glutathione S-alkyltransferase M4
, glutathione S-aralkyltransferase M4
, glutathione S-aryltransferase M4
, glutathione S-transferase Mu 4
, glutathione S-transferase mu 3
, glutathione S-transferase mu 4
, glutathione-S-transferase, mu 4