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Glyceraldehyde-3-Phosphate Dehydrogenase Proteins (GAPDH)

The product of GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). Additionally we are shipping GAPDH Antibodies (808) and GAPDH Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human GAPDH GAPDH 2597 P04406
Mouse GAPDH GAPDH 14433 P16858
Rat GAPDH GAPDH 24383 P04797
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Top GAPDH Proteins at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$480.00
Details
Yeast Chicken His tag Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) (AA 2-333) protein (His tag) expressed in E. coli 1 mg Log in to see 56 to 66 Days
$2,896.67
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$510.40
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) (AA 3-335), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

GAPDH Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced GAPDH Proteins

  1. Human GAPDH Protein expressed in Escherichia coli (E. coli) - ABIN2002045 : Tarze, Deniaud, Le Bras, Maillier, Molle, Larochette, Zamzami, Jan, Kroemer, Brenner: GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization. in Oncogene 2007 (PubMed)

More Proteins for Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaction Partners

Cow (Bovine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels

  2. present in, and accounts for, glycolysis and glutamate (show GRIN2A Proteins) accumulation into synaptic vesicles

  3. GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser (show SIGLEC1 Proteins)-416 & Thr (show TRH Proteins)-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase.

  4. Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle.

Arabidopsis thaliana Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation.

  2. The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC2]

Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. transient silencing of GAPDH reduces intracellular ROS (show ROS1 Proteins) and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.

  2. This review will summarize our current understanding of GAPDH-mediated regulation of RNA function

  3. analysis of PSCA (show PSCA Proteins) level in the peripheral blood of PC patients who underwent radical prostatectomy shows it is related to a GADPH reference level (PSCA (show PSCA Proteins)/GAPDH ratio)

  4. In 60 % of patients with type 2 diabetes, a reversible inhibition of GAPDH is observed.

  5. The results of this study led us to conclude that in cancer cells constantly exposed to conditions of oxidative stress, the protective power of Hsp70 (show HSP70 Proteins) should be abolished by specific inhibitors of Hsp70 (show HSP70 Proteins) expression.

  6. GAPDH and protoporphyrinogen oxidase (show PPOX Proteins) were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX reduced the growth of colon cancer cells in vitro

  7. The levels of GAPDH protein were significantly up-regulated in lung squamous cell carcinoma tissues and elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.

  8. Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.

  9. Data revealed that GAPDH is a phosphorylation substrate for AMPK (show PRKAA1 Proteins) and its interaction with Sirt1 (show SIRT1 Proteins) in the nucleus. The phosphorylation and the nuclear translocation of GAPDH mediate rapid Sirt1 (show SIRT1 Proteins) activation and autophagy initiation under glucose deprivation.

  10. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of diabetic retinopathy

Pig (Porcine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound.

Rabbit Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA

  2. The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.

  3. Purified UCH-L1 (show UCHL1 Proteins) and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.

  4. dissociation of alpha-crystallin and GAPDH

  5. results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.

  6. In the presence of alpha-crystallin or GroEL (show GroEL Proteins) the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

  7. The interactions described herein between the beta subunit (show POLG Proteins) of PhK (show PHKA2 Proteins) and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.

  8. FKBP36 (show FKBP6 Proteins) diminishes GAPDH activity by direct interaction and down-regulation of GAPDH

Mouse (Murine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR (show SRR Proteins).

  2. Selective inhibition of the glycolytic pathway through GAPDH in chronic lymphocytic leukemia cells with nanoliposomal C6-ceramide could be an effective therapy for leukemia by targeting the Warburg effect.

  3. glyceraldehyde-3-phosphate dehydrogenase plays a critical role in determining the superior functions of female bone marrow-derived mesenchymal stem cells in cell therapy against pulmonary arterial hypertension.

  4. Data indicate that the HNO-nonsteroidal anti-inflammatory drugs (NSAIDs) prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes.

  5. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor.

  6. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability.

  7. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase.

  8. Overexpression of GAPDH significantly augmented Mst1 (show MST1 Proteins) mediated apoptosis, whereas knockdown of GAPDH markedly attenuated Mst1 (show MST1 Proteins) activation and cardiomyocyte apoptosis.

  9. analysis of a GAPDH/PKCdelta (show PKCd Proteins) signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria

  10. For gene expression analysis in the developing murine neocortex, Gapdh is recommended as a reference gene based on the authors' ranking.

Xenopus laevis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. The effect of metal ions on the activity of glyceraldehyde-3-phosphate dehydrogenase.

Zebrafish Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) interaction partners

  1. amino acid sequences were used to establish the 3D structures of the active site of glyceraldehyde-3-phosphate dehydrogenase and the phylogenetic relationships of the sardine and octopus enzymes

  2. The expression level of GAPDH was upregulated to a greater extent than those for myogenin (show MYOG Proteins) and myostatin 1 under restricted feeding.

GAPDH Protein Profile

Protein Summary

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GAPDH

  • Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2)
  • glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
  • glyceraldehyde-3-phosphate dehydrogenase (gapdh)
  • glyceraldehyde 3-phosphate dehydrogenase (Gapdh)
  • glyceraldehyde 3-phosphate dehydrogenase (GAPC2)
  • similar to Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (GAPDH)
  • glyceraldehyde-3-phosphate dehydrogenase, type I (gapDH)
  • Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1)
  • glyceraldehyde-3-phosphate dehydrogenase (Gapdh)
  • glyceraldehyde-3-phosphate dehydrogenase-like (GAPDH)
  • olfactory receptor, family 8, subfamily K, member 3-like (LOC614985)
  • BEST:GH12586 protein
  • cb609 protein
  • CG8893 protein
  • CG12055 protein
  • Dmel\\CG8893 protein
  • Dmel\\CG12055 protein
  • G3PD protein
  • G3PDH protein
  • GA3PDH protein
  • gadph protein
  • GAP protein
  • GAPC-2 protein
  • gapd protein
  • gapdh protein
  • gapdh-1 protein
  • Gapdh-2 protein
  • GAPDH1 protein
  • GAPDH2 protein
  • Gapdh13F protein
  • Gapdh43E protein
  • GAPDH I protein
  • GAPDHI protein
  • GAPDH II protein
  • GB14798 protein
  • gh12586 protein
  • GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-2 protein
  • glyceraldehyde-3-phosphate dehydrogenase C2 protein
  • KNC-NDS6 protein
  • mg:bb02e05 protein
  • T6J4.17 protein
  • T6J4_17 protein
  • wu:fb33a10 protein
  • wu:ft80f05 protein

Protein level used designations for GAPDH

CG8893-PA , CG8893-PB , CG8893-PC , G3-P dehydrogenase , GAPDH2 , Gapdh2-PA , Gapdh2-PB , Gapdh2-PC , glyceraldehyde 3 phosphate dehydrogenase 2 , glyceraldehyde 3-phosphate dehydrogenase , glyceraldehyde-3-phosphate dehydrogenase , glyceraldehyde phosphate dehydrogenase , peptidyl-cysteine S-nitrosylase GAPDH , glyceraldehyde-3-phosphate dehydrogenase, type I , glyceraldehyde-3-phosphate dehydrogenase-like , CG12055-PA , CG12055-PB , GAPDH1 , Gapdh1-PA , Gapdh1-PB , Glyceraldehyde-3-phosphate dehydrogenase1 , glyceraldehyde 3 phosphate dehydrogenase , glyceraldehyde 3 phosphate dehydrogenase 1 , glyceraldehyde 3 phosphate dehydrogenase1 , aging-associated gene 9 protein , 38 kDa BFA-dependent ADP-ribosylation substrate , BARS-38 , bb02e05

GENE ID SPECIES
32545 Drosophila melanogaster
281181 Bos taurus
448356 Xenopus (Silurana) tropicalis
410122 Apis mellifera
837904 Arabidopsis thaliana
100135863 Oncorhynchus mykiss
574353 Macaca mulatta
712631 Macaca mulatta
2734417 Bdellovibrio bacteriovorus HD100
8970424 Mycoplasma crocodyli MP145
100404960 Callithrix jacchus
100478741 Ailuropoda melanoleuca
35728 Drosophila melanogaster
374193 Gallus gallus
2597 Homo sapiens
396823 Sus scrofa
100009074 Oryctolagus cuniculus
14433 Mus musculus
24383 Rattus norvegicus
380259 Xenopus laevis
403755 Canis lupus familiaris
100860872 Capra hircus
493876 Felis catus
451783 Pan troglodytes
100135525 Cavia porcellus
317743 Danio rerio
443005 Ovis aries
100033897 Equus caballus
100172694 Pongo abelii
786101 Bos taurus
614985 Bos taurus
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