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The product of GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). Additionally we are shipping GAPDH Proteins (72) and GAPDH Kits (43) and many more products for this protein.
Showing 10 out of 829 products:
Dog (Canine) Polyclonal GAPDH Primary Antibody for EIA, IF - ABIN374435
Happold, Roth, Wick, Schmidt, Florea, Silginer, Reifenberger, Weller: Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells. in Journal of neurochemistry 2013
Show all 7 references for ABIN374435
Broad Bean (Vicia faba) Polyclonal GAPDH Primary Antibody for EIA, IF - ABIN401403
Sirover: New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells. in Journal of cellular biochemistry 2005
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Dog (Canine) Polyclonal GAPDH Primary Antibody for EIA, IHC (fro) - ABIN374640
Chakir, Daya, Aiba, Tunin, Dimaano, Abraham, Jaques-Robinson, Jacques, Lai, Pacak, Zhu, Xiao, Tomaselli, Kass: Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. in Circulation 2009
Show all 6 references for ABIN374640
Human Polyclonal GAPDH Primary Antibody for FACS, IF - ABIN392354
Azam, Jouvet, Jilani, Vongsamphanh, Yang, Yang, Ramotar: Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1. in The Journal of biological chemistry 2008
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Human Polyclonal GAPDH Primary Antibody for EIA, IHC (p) - ABIN360236
Lu, Suzuki, Lu, Suzuki: Involvement of glyceraldehyde-3-phosphate dehydrogenase in the X-Ray resistance of HeLa cells. in Bioscience, biotechnology, and biochemistry 2008
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Human Polyclonal GAPDH Primary Antibody for EIA, FACS - ABIN360237
Zhou, Yi, Stoffer, Bonafe, Gilmore-Hebert, McAlpine, Chambers: The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer. in Molecular cancer research : MCR 2008
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Human Monoclonal GAPDH Primary Antibody for EIA, IF - ABIN492380
Chuang, Hough, Senatorov: Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. in Annual review of pharmacology and toxicology 2005
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Cow (Bovine) Polyclonal GAPDH Primary Antibody for IHC, WB - ABIN2778645
Rinne, Clements, Lamme, Duijf, Bolat, Meijer, Scheffer, Rosser, Tan, McGrath, Schalkwijk, Brunner, Zhou, van Bokhoven: A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes. in Human molecular genetics 2008
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GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels
present in, and accounts for, glycolysis and glutamate (show GRIN2A Antibodies) accumulation into synaptic vesicles
GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser (show SIGLEC1 Antibodies)-416 & Thr (show TRH Antibodies)-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase.
Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle.
GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation.
The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC2]
This suggests that RX624 might be useful as a drug against polyglutamine pathologies, and that is could be administered exogenously without affecting target cell physiology. This protective effect was validated by the similar effect of an anti-GAPDH specific antibody.
GAPDH can interact with proteins participating in DNA repair, such as APE1 (show APEX1 Antibodies), PARP1 (show PARP1 Antibodies), HMGB1 (show HMGB1 Antibodies), and HMGB2 (show HMGB2 Antibodies). In this review, the functions of GAPDH associated with DNA repair are discussed in detail.
Nitric oxide-induced GAPDH aggregation specifically induces mitochondrial dysfunction via permeability transition pore opening, leading to cell death.
GAPDH may act as a chaperone in heme transfer to downstream areas
NAD(+) inhibited both GAPDH aggregation and co-aggregation with GOSPEL (show RILPL1 Antibodies), a hitherto undescribed effect of the coenzyme against the consequences of oxidative stress.
Monoclonal Antibodies DSHB-hGAPDH-2G7 and DSHB-hGAPDH-4B7 Against Human Glyceraldehyde-3-Phosphate Dehydrogenase.
the present study suggests that GAPDH plays an important role in cancer metastasis by affecting EMT (show ITK Antibodies) through regulation of Sp1 (show PSG1 Antibodies)-mediated SNAIL (show SNAI1 Antibodies) expression.
Knockdown of LAMP2A, a CMA-related protein, and TSG101 (show TSG101 Antibodies), an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH-HT in AD293 cells and primary cultured rat cortical neurons.
In conclusion, the data show that two GAPDH binders could be therapeutically relevant in the treatment of injuries stemming from hard oxidative stress.
transient silencing of GAPDH reduces intracellular ROS (show ROS1 Antibodies) and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.
The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound.
The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA
The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.
Purified UCH-L1 (show UCHL1 Antibodies) and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.
dissociation of alpha-crystallin and GAPDH
results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.
In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.
The interactions described herein between the beta subunit (show POLG Antibodies) of PhK (show PHKA2 Antibodies) and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.
FKBP36 (show FKBP6 Antibodies) diminishes GAPDH activity by direct interaction and down-regulation of GAPDH
Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC (show SCNN1A Antibodies) Activity
Data indicate that lactoferrin (show LTF Antibodies) uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR (show SRR Antibodies).
Selective inhibition of the glycolytic pathway through GAPDH in chronic lymphocytic leukemia cells with nanoliposomal C6-ceramide could be an effective therapy for leukemia by targeting the Warburg effect.
glyceraldehyde-3-phosphate dehydrogenase plays a critical role in determining the superior functions of female bone marrow-derived mesenchymal stem cells in cell therapy against pulmonary arterial hypertension.
Data indicate that the HNO-nonsteroidal anti-inflammatory drugs (NSAIDs) prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase.
Overexpression of GAPDH significantly augmented Mst1 (show MST1 Antibodies) mediated apoptosis, whereas knockdown of GAPDH markedly attenuated Mst1 (show MST1 Antibodies) activation and cardiomyocyte apoptosis.
The effect of metal ions on the activity of glyceraldehyde-3-phosphate dehydrogenase.
amino acid sequences were used to establish the 3D structures of the active site of glyceraldehyde-3-phosphate dehydrogenase and the phylogenetic relationships of the sardine and octopus enzymes
The expression level of GAPDH was upregulated to a greater extent than those for myogenin (show MYOG Antibodies) and myostatin 1 under restricted feeding.
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.
, G3-P dehydrogenase
, glyceraldehyde 3 phosphate dehydrogenase 2
, glyceraldehyde 3-phosphate dehydrogenase
, glyceraldehyde-3-phosphate dehydrogenase
, glyceraldehyde phosphate dehydrogenase
, peptidyl-cysteine S-nitrosylase GAPDH
, glyceraldehyde-3-phosphate dehydrogenase, type I
, glyceraldehyde-3-phosphate dehydrogenase-like
, Glyceraldehyde-3-phosphate dehydrogenase1
, glyceraldehyde 3 phosphate dehydrogenase
, glyceraldehyde 3 phosphate dehydrogenase 1
, glyceraldehyde 3 phosphate dehydrogenase1
, aging-associated gene 9 protein
, 38 kDa BFA-dependent ADP-ribosylation substrate