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The protein encoded by GPD2 localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor.
hepatic metabolite perturbations in citrin (show slc25a13 Antibodies)-mitochondrial glycerol-3-phosphate dehydrogenase (show GPD1 Antibodies) double-knockout mice, a model of human citrin (show slc25a13 Antibodies) deficiency
GPD2 activity is required for generation of reactive oxygen species in mouse spermatozoa during capacitation, failing which, capacitation is impaired.
mitochondrial GPD (show DARC Antibodies) knockout mice have normal thyroid thermogenesis but reduced viability and adiposity
Knockout mice deficient in both cytosolic and mitochondrial GPD (show DARC Antibodies) have lethal hypoglycemic ketosis and glyceroluria.
role for mitochondrial gpd (show DARC Antibodies) in thyroid hormone (show PTH Antibodies) thermogenesis.
phenotypic analysis of citrin (show slc25a13 Antibodies)/mitochondrial glycerol-3-phosphate dehydrogenase (show GPD1 Antibodies) double knock-out mice
the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS (show ROS1 Antibodies) generation and may result in the progression of prostate cancer
testis-specific (show THEG Antibodies) promoter of mitochondrial GPDH (show GPD1 Antibodies)
Overall, these data demonstrate that mGPDH is involved in maintaining a high rate of glycolysis and is an important site of electron leakage leading to ROS (show ROS1 Antibodies) production in prostate cancer cells.
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
, glycerol-3-phosphate dehydrogenase, mitochondrial
, glycerol-3-phosphate dehydrogenase, mitochondrial-like
, FAD-linked glycerol-3-phosphate dehydrogenase
, glycerol phosphate dehydrogenase 1, mitochondrial
, glycerol-3-phosphate dehydrogenase 2, mitochondrial
, glycerol-3-phosphate dehydrogenase G3PD
, mitochondrial glycerophosphate dehydrogenase
, glycerolphosphate dehydrogenase
, Glycerol-3-phosophate dehydrogenase 2 (mitochondrial)
, mtGPDH gene, promoter region and alternative transcripts