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a putative membrane glycerophosphodiester phosphodiesterase\; may mediate lipid metabolism and G protein signaling [RGD, Feb 2006].. Additionally we are shipping GDE1 Antibodies (54) and GDE1 Kits (4) and many more products for this protein.
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The expression levels of two target genes, Myb (show MYB Proteins) and VEGFR2 (show KDR Proteins), were affected significantly by miR-16, while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration.
Quercetin decreases claudin-2 (show CLDN2 Proteins) expression mediated by up-regulation of miR-16 expression and instability of claudin-2 (show CLDN2 Proteins) mRNA in lung adenocarcinoma cells.
Our data indicate differential concentrations of plasma miR-16, miR (show MLXIP Proteins)-107, miR (show MLXIP Proteins)-130a and miR (show MLXIP Proteins)-146a in different breast cancer subtypes, suggesting a potential role of these miRs in breast cancer biology and tumor progression.
YAP1 (show YAP1 Proteins) was confirmed to be a functional target of miR (show MLXIP Proteins)-15a and miR-16-1 in GAC (show GLS Proteins).
miR-16 and miR (show MLXIP Proteins)-26a target checkpoint kinases Wee1 (show WEE1 Proteins) and Chk1 (show CHEK1 Proteins) in response to p53 (show TP53 Proteins) activation by genotoxic stress.
Up-regulation of miR-16 is associated with triple negative breast cancer.
This study demonistrated that miR (show MLXIP Proteins)-15a and 16-1 are downregulated in CD4 (show CD4 Proteins)+ T cells of multiple sclerosis relapsing patients.
miR-16 and miR (show MLXIP Proteins)-21 are directly regulated by the transcription factor NF-kappaB (show NFKB1 Proteins) and yet nicotine-promoted cell proliferation is mediated via EP2 (show SPAG11B Proteins)/4 receptors.
Results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis.
These findings suggest that genes other than miR (show MLXIP Proteins)-15a and miR-16 may explain the prognostic significance of 13q14 deletions in patients with multiple myeloma
The authors confirmed the role of Gde1 in NAFLD by in vivo hepatic over-expression and shRNA knockdown studies.
findings designate GroPSer as a previously unappreciated reservoir for free serine in the nervous system and suggest that GDE1, through recycling serine from GroPSer, may impact D-serine-dependent neural signaling processes in vivo
regulation by by stimulation of G protein-coupled receptors
a multistep pathway for the production of anandamide in the nervous system by the sequential actions of Abh4 (show ABHD4 Proteins) and GDE1.
a putative membrane glycerophosphodiester phosphodiesterase\; may mediate lipid metabolism and G protein signaling
RGS16-interacting membrane protein
, membrane interacting protein of RGS16
, membrane-interacting protein of RGS16