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GATM encodes a mitochondrial enzyme that belongs to the amidinotransferase family. Additionally we are shipping GATM Antibodies (85) and GATM Kits (14) and many more products for this protein.
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Human GATM Protein expressed in Escherichia coli (E. coli) - ABIN668032
Cullen, Yuen, Felkin, Smolenski, Hall, Grindle, Miller, Birks, Yacoub, Barton: Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis. in Circulation 2006
Show all 2 references for ABIN668032
AGAT deficiency is a treatable intellectual disability.
Meta-analysis yielded a marginal, but null, association of GATM rs9806699 with statin-induced myopathy.
Genome-wide association reveals that plasma homoarginine is strongly associated with single nucleotide polymorphisms in the AGAT gene.
promiscuous activity of AGAT, a key enzyme in creatine synthesis, plays a pivotal role in homoarginine synthesis
GATM sequencing revealed a homozygous single nucleotide insertion 1111_1112insA, producing a frame-shift at Met-371 and premature termination at codon 376.
AGAT mRNA expression was significantly elevated in all heart failure patients and returned to normal levels after recovery, suggesting a specific response to heart failure involving elevated local creatine synthesis.
For the GATM BseLI polymorphism, the Yorkshire and Duroc breeds have higher allele frequencies at the G allele, whereas the local pigs have higher allele frequencies at the A allele. (GATM; glycine amidinotransferase)
results show marked metabolic effects of creatine deficiency via the chronic activation of AMPK (show PRKAA1 Proteins) in a first animal model of AGAT deficiency
The spatiotemporal expression pattern of gatm during zebrafish embryogenesis was revealed.
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.
, glycine amidinotransferase, mitochondrial
, arginine:glycine amidinotransferase
, L-arginine: glycine amidinotransferase
, l-arginine:glycine amidinotransferase