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Glycine N-Methyltransferase Proteins (GNMT)

The protein encoded by GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. Additionally we are shipping GNMT Antibodies (67) and GNMT Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNMT 14711 Q9QXF8
Rat GNMT GNMT 25134 P13255
GNMT 27232 Q14749
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Top GNMT Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,772.00
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,772.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 3 to 4 Days
$190.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$273.57
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   10 μg Log in to see 6 Days
$168.54
Details

GNMT Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced GNMT Proteins

  1. Human GNMT Protein expressed in Escherichia coli (E. coli) - ABIN666718 : Huang, Chen, Shyr, Su, Chen, Li, Ho, Chen: Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. in Journal of gastroenterology and hepatology 2008 (PubMed)
    Show all 2 references for ABIN666718

More Proteins for Glycine N-Methyltransferase (GNMT) Interaction Partners

Mouse (Murine) Glycine N-Methyltransferase (GNMT) interaction partners

  1. GNMT is involved in the pathogenesis of experimental autoimmune encephalomyelitis and plays a crucial role in the regulation of CD4 (show CD4 Proteins)+ T-cell functions

  2. GNMT is found in the hippocampus and regulates intracellular SAMe levels. GNMT deficiency in mice results in high SAMe levels within the hippocampus, reduced neurogenic capacity, and spatial learning and memory impairment.

  3. It may be a crucial molecule in the pathogenesis of DSS (show PMP22 Proteins)-induced colitis.

  4. Gnmt plays important role in maintaining normal function of brain; deficiency of Gnmt causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior.

  5. Reduced expression of GNMT in mouse hepatoma cells appears to increase the activity of LKB1/RAS signaling.

  6. NK cells from GNMT(-/-) mice were spontaneously activated, expressed more TRAIL, and had strong cytotoxic activity, suggesting their contribution to the proinflammatory environment in the liver.

  7. This is the first report demonstrating that GNMT plays an important role in regulating cholesterol homeostasis via interaction with NPC2 (show NPC2 Proteins)

  8. Higher susceptibility to aflatoxin B(1)-related hepatoma in Gnmt deficient mice.

  9. Loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways.

  10. GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models

Human Glycine N-Methyltransferase (GNMT) interaction partners

  1. In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk.

  2. GNMT is an androgen receptor (show AR Proteins)-targeted gene with its functional androgen response element located at +19/+33 of the first exon.

  3. The studies identify GNMT as a direct transcriptional target of the AR.

  4. DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC (show FAM126A Proteins)), and loss of GNMT in human HCC (show FAM126A Proteins) could promote the establishment of aberrant DNA methylation (show HELLS Proteins) patterns at specific gene promoters

  5. single-nucleotide polymorphisms in VEGF (show VEGFA Proteins), IL-10 (show IL10 Proteins) and GNMT genes might have a synergistic role in the development of Prostate cancer

  6. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A (show MAT1A Proteins) levels.

  7. GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior.

  8. GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis.

  9. In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR (show DEPTOR Proteins) and modulating mTOR (show FRAP1 Proteins)/raptor (show RPTOR Proteins) signaling pathway

  10. This is the first report demonstrating that GNMT plays an important role in regulating cholesterol homeostasis via interaction with NPC2 (show NPC2 Proteins)

GNMT Protein Profile

Protein Summary

The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).

Gene names and symbols associated with GNMT

  • glycine N-methyltransferase (CpipJ_CPIJ015956)
  • glycine N-methyltransferase (Gnmt)
  • glycine N-methyltransferase (GNMT)

Protein level used designations for GNMT

glycine N-methyltransferase , glycine N methyl transferase , folate-binding protein , glycine methyltransferase

GENE ID SPECIES
6049618 Culex quinquefasciatus
14711 Mus musculus
25134 Rattus norvegicus
27232 Homo sapiens
474905 Canis lupus familiaris
397444 Sus scrofa
538212 Bos taurus
100009512 Oryctolagus cuniculus
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