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Glycine Receptor, alpha 1 (GLRA1) ELISA Kits

The protein encoded by GLRA1 is a subunit of a pentameric inhibitory glycine receptor. Additionally we are shipping GLRA1 Antibodies (53) and GLRA1 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat GLRA1 GLRA1 25674 P07727
Anti-Human GLRA1 GLRA1 2741 P23415
Anti-Mouse GLRA1 GLRA1 14654  
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More ELISA Kits for GLRA1 Interaction Partners

Human Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. GLRA1 and GLRB (show GLRB ELISA Kits) mutations are responsible for abnormal startled reactions in humans. (Review)

  2. in two sisters with hyperekplexia a compound heterozygosis of 2 novel mutations of GLRA1 gene was found - heterozygous for a C-to-G base transition resulting in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to arginine amino acid change in position 237

  3. the TM3 (show TPM1 ELISA Kits)-4 loop length is critical for glycine receptor (show GLRB ELISA Kits) alpha1 desensitization and a direct neighborhood of both basic stretches changes receptor properties from non-desensitizing to desensitizing.

  4. Mutations in the GLRA1 were identified in 16 Japanese patients with hyperekplexia.

  5. The first X-ray structure of the TMD (show TTN ELISA Kits) of the alpha1GlyR solved here using GLIC as a scaffold paves the way for mechanistic investigation and design of allosteric modulators of a human receptor.

  6. In GlyRA1 mutants, a portion of them can be transported to the plasma membrane but don't form funtional channels; a possible cause for hyperekplexia.

  7. Conformation and function of the human GLRA1 chloride channel (show CLCA1 ELISA Kits).

  8. Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor (show GLRB ELISA Kits) activation.

  9. Glycine receptor (show GLRB ELISA Kits) alpha1 subunit specific-autoantibody study aids identification of autoimmune brainstem/spinal cord hyperexcitability disorders and may extend to the glycinergic visual system.

  10. TM3 (show TPM1 ELISA Kits)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

Zebrafish Glycine Receptor, alpha 1 (GLRA1) interaction partners

Mouse (Murine) Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. Mutation of a zinc-binding residue in the glycine receptor (show GLRB ELISA Kits) alpha1 changes ethanol sensitivity in vitro and alcohol consumption in Glra1(D80A) knock-in mice.

  2. TM3 (show TPM1 ELISA Kits)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

  3. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, resulted in a small but general impairment of glycine action, that is most evident in the glycine-induced maximal currents.

  4. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, decreased specific behavioral actions of ethanol and altered other nonethanol behaviors, demonstrating the importance of GlyR function in diverse neuronal systems.

  5. The values of breathing frequency, tidal volume, and minute ventilation in newborn Glra1-deficient oscillator mice decrease rapidly during postnatal development.

  6. The new Glra1 mutation appears to affect glycine's inhibitory neurotransmission in the central nervous system (CNS) of the nmf11 homozygotes, which suffer from a severe startle disease-related phenotype and die by postnatal day 21.

  7. Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs (show GARS ELISA Kits), indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.

  8. These results show that insulin (show INS ELISA Kits) has a novel regulatory action on the potency of glycine for ionotropic glycine receptors.

GLRA1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLRA1

  • glycine receptor, alpha 1 (GLRA1) antibody
  • glycine receptor subunit alpha-1-like (LOC100513384) antibody
  • glycine receptor, alpha 1 (Glra1) antibody
  • glycine receptor, alpha 1 (glra1) antibody
  • glycine receptor, alpha 1 subunit (Glra1) antibody
  • B230397M16Rik antibody
  • GLYRA1 antibody
  • HKPX1 antibody
  • nmf11 antibody
  • oscillator antibody
  • ot antibody
  • spasmodic antibody
  • spd antibody
  • STHE antibody
  • [a]Z1 antibody

Protein level used designations for GLRA1

glycine receptor, alpha 1 (startle disease/hyperekplexia) , glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) , glycine receptor, alpha 1 , glycine receptor subunit alpha-1-like , glycine receptor 48 kDa subunit , glycine receptor strychnine-binding subunit , glycine receptor subunit alpha-1 , glycine receptor, alpha 1 subunit , GlyR [a]Z1 , glycine receptor subunit alphaZ1 , glycine receptor, alphaZ1 subunit , glycine receptor alpha 1 subunit

GENE ID SPECIES
471712 Pan troglodytes
100446940 Pongo abelii
100473634 Ailuropoda melanoleuca
100546420 Meleagris gallopavo
100513384 Sus scrofa
25674 Rattus norvegicus
2741 Homo sapiens
30676 Danio rerio
489172 Canis lupus familiaris
281783 Bos taurus
427637 Gallus gallus
100060055 Equus caballus
100344552 Oryctolagus cuniculus
14654 Mus musculus
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