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Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. Additionally we are shipping Glycophorin B (MNS Blood Group) Antibodies (37) and many more products for this protein.
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MNSs blood group (show DARC Proteins) glycophorin variants in Taiwan: a genotype-serotype correlation study of 'Mi(a)' and St(a) with report of two new alleles for St(a).
A novel GYPB mutation (c.270+5G>A) accounting for the S-s-U+(var) phenotype was identified.
Substitution of GPB with Gp.Mur significantly reduced the expression of Rh antigen and RhAG (show RHAG Proteins) on the Mi.III(+/+) erythrocyte membrane
an increased susceptibility to infection by this parasite is associated with the glycophorin B S+ variant in Brazilian Amazons
Indochina I strain of P. falciparum is not dependent on glycophorin B to invade erythrocytse through a trypsin-resistant pathway as are the strains 3D7, HB3, and Dd2.
The S-s-U+var phenotype arises from changes in or around GYPB exon 5.
GYPA (show GYPA Proteins) & GYPB genotypes carrying MNSs antigens were analyzed in Thai patients with cerebral malaria & mild malaria; no statistical difference was found; it is concluded that MNSs antigens do not reveal the difference in susceptibility to cerebral malaria
Alternative to conventional tube technique for mass screening for MNS hybrids, especially when specific antisera are not available.
Immunoblotting showed the presence of monomer and dimer forms of a GP(A-B) hybrid and an absence of GPA (show GYPA Proteins) and GPB. Sequencing of DNA and PCR-RFLP using the restriction enzyme RsaI confirmed the presence of a hybrid GYP(AB).
The erythrocyte-binding domain, region 2 of EBL-1, bound glycophorin B(+) but
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta\\\\; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
, Ss blood group
, glycophorin HeP2
, glycophorin MiIII
, glycophorin MiVI
, glycophorin MiX
, sialoglycoprotein delta