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anti-Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) Antibodies

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. Additionally we are shipping GP1BB Proteins (9) and GP1BB Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GP1BB 2812 P13224
GP1BB 116727 Q9JJM7
GP1BB 14724 P56400
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Top anti-GP1BB Antibodies at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis of CD42c expression in Raji (A), HL60 (B), SP2/0 (C), rat heart (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IHC (p), IP, WB Human Spleen (formalin-fixed, paraffin-embedded) stained with GP1BB antibody ABIN396968 at 1:50 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$595.83
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$376.20
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 6 to 11 Days
$485.71
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$429.00
Details
Rat Rabbit Biotin ELISA, WB   100 μg Log in to see 8 to 10 Days
$654.50
Details
Rat Rabbit FITC WB   100 μg Log in to see 8 to 10 Days
$698.50
Details
Rat Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$522.50
Details

GP1BB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human
,
,
Rat (Rattus) ,


,
Mouse (Murine)


More Antibodies against GP1BB Interaction Partners

Human Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX (show GP9 Antibodies) transmembrane domains.

  2. Low levels of CD9 (show CD9 Antibodies) coincidental with a novel nonsense mutation in glycoprotein Ibbeta in a patient with Bernard-Soulier syndrome.

  3. genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA (show GP1BA Antibodies), GP1BB) and GP9 (show GP9 Antibodies) are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.

  4. a suspicion of 22q11.2 deletion is warranted in pediatric BSS (show GP1BA Antibodies) patients with a mutation in the GPIbbeta gene, even without remarkable symptoms.

  5. Studies indicate that platelets from Bernard-Soulier syndrome (BSS (show GP1BA Antibodies)) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha (show GP1BA Antibodies) disulfide linked to GPIbbeta, and noncovalently associated with GPIX (show GP9 Antibodies) and GPV (show GP5 Antibodies).

  6. GPIbbeta missense mutations from Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Mutations A108P and P74R were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX (show GP9 Antibodies) surface expression

  7. GPIIb (show ITGA2B Antibodies)/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin (show ALB Antibodies) irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role.

  8. GP Ibbeta/GP IX (show GP9 Antibodies) mediates the disulfide-linked GP Ibalpha localization to the GEMs, which is critical for vWf (show VWF Antibodies) interaction at high shear

  9. Identify TRAF4 (show TRAF4 Antibodies) as a novel binding partner for GPIb-IX-V and GPVI (show GP6 Antibodies) in human platelets.

  10. putative convex surface of the LRR domain in GPIX (show GP9 Antibodies) is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta

Mouse (Murine) Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. Data show that the surface-bound VWF (show VWF Antibodies) appears as a large, linear structure on the surface of 50% of the PT-VWD (show VWF Antibodies) platelets.

  2. Role of GPIbbeta in modulating vWF (show VWF Antibodies) mediated platelet adhesion.

GP1BB Antigen Profile

Protein Summary

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described\; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.

Gene names and symbols associated with GP1BB

  • glycoprotein Ib (platelet), beta polypeptide (GP1BB) antibody
  • glycoprotein Ib (platelet), beta polypeptide (Gp1bb) antibody
  • glycoprotein Ib, beta polypeptide (Gp1bb) antibody
  • BDPLT1 antibody
  • BS antibody
  • CD42C antibody
  • GPIBB antibody

Protein level used designations for GP1BB

glycoprotein Ib (platelet), beta polypeptide , GP-Ib beta , antigen CD42b-beta , nuclear localization signal deleted in velocardiofacial syndrome , platelet glycoprotein Ib beta chain , GPIb-beta , GPIbB , glycoprotein Ib, beta polypeptide

GENE ID SPECIES
416780 Gallus gallus
608234 Canis lupus familiaris
2812 Homo sapiens
116727 Rattus norvegicus
14724 Mus musculus
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