You are viewing an incomplete version of our website. Please click to reload the website as full version.

Glycoprotein Ib (Platelet), beta Polypeptide Proteins (GP1BB)

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. Additionally we are shipping GP1BB Antibodies (22) and GP1BB Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GP1BB 2812 P13224
GP1BB 116727 Q9JJM7
GP1BB 14724 P56400
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top GP1BB Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$437.80
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,240.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,249.50
Details

GP1BB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus) , ,
, ,
Mouse (Murine) ,
,

More Proteins for Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) Interaction Partners

Human Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. Data show that localization of the GP Ib-IX complex to the lipid domain is mediated by GP Ibbeta and GP IX (show GP9 Proteins) transmembrane domains.

  2. Low levels of CD9 (show CD9 Proteins) coincidental with a novel nonsense mutation in glycoprotein Ibbeta in a patient with Bernard-Soulier syndrome.

  3. genetic association study in population in western India: Data suggest novel mutations in platelet glycoprotein Ib (GP1BA (show GP1BA Proteins), GP1BB) and GP9 (show GP9 Proteins) are associated with Bernard-Soulier syndrome in subjects studies; of 12 mutations identified, ten were novel.

  4. a suspicion of 22q11.2 deletion is warranted in pediatric BSS (show GP1BA Proteins) patients with a mutation in the GPIbbeta gene, even without remarkable symptoms.

  5. Studies indicate that platelets from Bernard-Soulier syndrome (BSS) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha disulfide linked to GPIbbeta, and noncovalently associated with GPIX and GPV.

  6. GPIbbeta missense mutations from Bernard-Soulier syndrome were examined for changes to GPIb-IX complex surface expression. Mutations A108P and P74R were found to maintain normal secretion/folding of GPIbbeta(E) but were unable to support GPIX (show GP9 Proteins) surface expression

  7. GPIIb/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin (show ALB Proteins) irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role.

  8. GP Ibbeta/GP IX (show GP9 Proteins) mediates the disulfide-linked GP Ibalpha localization to the GEMs, which is critical for vWf (show VWF Proteins) interaction at high shear

  9. Identify TRAF4 (show TRAF4 Proteins) as a novel binding partner for GPIb-IX-V and GPVI (show GP6 Proteins) in human platelets.

  10. putative convex surface of the LRR domain in GPIX (show GP9 Proteins) is sufficient, in the context of full-length subunit, to mediate its association with GPIbbeta

Mouse (Murine) Glycoprotein Ib (Platelet), beta Polypeptide (GP1BB) interaction partners

  1. Data show that the surface-bound VWF (show VWF Proteins) appears as a large, linear structure on the surface of 50% of the PT-VWD (show VWF Proteins) platelets.

  2. Role of GPIbbeta in modulating vWF (show VWF Proteins) mediated platelet adhesion.

GP1BB Protein Profile

Protein Summary

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described\; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.

Gene names and symbols associated with GP1BB

  • glycoprotein Ib (platelet), beta polypeptide (GP1BB)
  • glycoprotein Ib (platelet), beta polypeptide (Gp1bb)
  • glycoprotein Ib, beta polypeptide (Gp1bb)
  • BDPLT1 protein
  • BS protein
  • CD42C protein
  • GPIBB protein

Protein level used designations for GP1BB

glycoprotein Ib (platelet), beta polypeptide , GP-Ib beta , antigen CD42b-beta , nuclear localization signal deleted in velocardiofacial syndrome , platelet glycoprotein Ib beta chain , GPIb-beta , GPIbB , glycoprotein Ib, beta polypeptide

GENE ID SPECIES
416780 Gallus gallus
608234 Canis lupus familiaris
2812 Homo sapiens
116727 Rattus norvegicus
14724 Mus musculus
Selected quality suppliers for GP1BB Proteins (GP1BB)
Did you look for something else?