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Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. Additionally we are shipping GP5 Kits (24) and and many more products for this protein.
Showing 10 out of 28 products:
Mouse (Murine) Monoclonal GP5 Primary Antibody for FACS - ABIN2664689
Andrews, Harris, McNally, Berndt: Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. in Biochemistry 1998
Show all 11 references for ABIN2664689
Mouse (Murine) Monoclonal GP5 Primary Antibody for FACS - ABIN2660118
Hickey, Hagen, Yagi, Roth: Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. in Proceedings of the National Academy of Sciences of the United States of America 1993
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Mouse (Murine) Monoclonal GP5 Primary Antibody for FACS - ABIN2662644
Inoue, Suzuki-Inoue, Ozaki: Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V. in The Journal of biological chemistry 2008
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Mouse (Murine) Monoclonal GP5 Primary Antibody for ICFC - ABIN2658230
Ravanat, Morales, Azorsa, Moog, Schuhler, Grunert, Loew, Van Dorsselaer, Cazenave, Lanza: Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. in Blood 1997
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Mouse (Murine) Monoclonal GP5 Primary Antibody for IHC (fro), FACS - ABIN2689254
Sato, Kiyokawa, Taguchi, Suzuki, Sekino, Ohmi, Itagaki, Sato, Lepage, Lanza, Fujimoto: Functional conservation of platelet glycoprotein V promoter between mouse and human megakaryocytes. in Experimental hematology 2000
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Human Monoclonal GP5 Primary Antibody for Func, IF - ABIN1106368
Modderman, Admiraal, Sonnenberg, von dem Borne: Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. in The Journal of biological chemistry 1992
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Mouse (Murine) Monoclonal GP5 Primary Antibody for FACS - ABIN2678951
Takada, Saito, Kaneko, Iizuka, Kokai, Fujimoto: Novel monoclonal antibody reactive with thrombin-sensitive 74-kDa glycoproteins present on platelets and megakaryocytes both from mouse and rat. in Hybridoma 1996
Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha (show GP1BA Antibodies) and GPV for MP-dependent cleavage.
GPV is cleaved upon agonist-induced platelet activation, with ADAM17 (show ADAM17 Antibodies) as the major enzyme mediating this process
GPIbalpha (show GP1BA Antibodies) and GPV are shed through an ADAM17 (show ADAM17 Antibodies)-dependent mechanism after aspirin administration
ROLE OF GPV IN HEMOSTASIS AND THROMBOSIS IS PROBABLY OF LESSER IMPORTANCE THAN PREVIOUSLY THOUGHT
Studies indicate that platelets from Bernard-Soulier syndrome (BSS (show GP1BA Antibodies)) are defective in glycoprotein (GP)Ib-IX-V, a platelet-specific adhesion-signaling complex, composed of GPIbalpha (show GP1BA Antibodies) disulfide linked to GPIbbeta, and noncovalently associated with GPIX (show GP9 Antibodies) and GPV.
GPIIb (show ITGA2B Antibodies)/IIIa is the primary receptor set involved in platelet adhesion to adsorbed fibrinogen and serum albumin (show ALB Antibodies) irrespective of their degree of adsorption-induced unfolding, while the GPIb-IX-V receptor complex plays an insignificant role.
Both the high affinity thrombin receptor (show F2R Antibodies) (GPIb-IX-V) and GPIIb (show ITGA2B Antibodies)/IIIa are implicated in expression of thrombin (show F2 Antibodies)-induced platelet procoagulant activity.
laminin supports platelet adhesion depending on the interaction of VWF (show VWF Antibodies) and GPIb-IX-V under pathophysiological high shear flow
glycoprotein Ib-IX-V complex contributes to tissue factor (show F3 Antibodies)-independent thrombin (show F2 Antibodies) generation by recombinant factor VIIa on the activated platelet surface
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998
glycoprotein 5 (platelet)
, platelet glycoprotein V
, glycoprotein V (platelet)
, platelet glycoprotein V-like
, Platelet glycoprotein 5
, Platelete glycoprotein 5
, glycoprotein 5, platelet
, glycoprotein 5