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anti-Glycoprotein VI (Platelet) (GP6) Antibodies

GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. Additionally we are shipping GP6 Kits (31) and GP6 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GP6 243816 P0C191
GP6 51206 Q9HCN6
GP6    
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Top anti-GP6 Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-GP6 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of GPVI in A-20 lysate with AP30379PU-N GPVI antibody at 1μg/ml in either the absence or (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 μg/ml. Western blot analysis of GPVI in A20 lysate with AP30378PU-N GPVI antibody at 1μg/ml in either the absence or (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated FACS, WB GP6 Antibody (C-term) (ABIN651878) western blot analysis in K562 cell line lysates (15 µg/lane). This demonstrates the GP6 antibody detected the GP6 protein (arrow). GP6 Antibody (C-term) (ABIN651878) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 8 to 10 Days
$683.83
Details
Human Rabbit APC FACS, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
$365.20
Details

GP6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GP6 Antibodies

  1. Human Polyclonal GP6 Primary Antibody for EIA, WB - ABIN499918 : Jarvis, Atkinson, Snell, Watson: Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens. in British journal of pharmacology 2002 (PubMed)
    Show all 5 references for ABIN499918

  2. Human Polyclonal GP6 Primary Antibody for EIA, IF - ABIN499916 : Jandrot-Perrus, Busfield, Lagrue, Xiong, Debili, Chickering, Le Couedic, Goodearl, Dussault, Fraser, Vainchenker, Villeval: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. in Blood 2000 (PubMed)
    Show all 4 references for ABIN499916

  3. Human Polyclonal GP6 Primary Antibody for WB - ABIN2782886 : Gardiner, Karunakaran, Arthur, Mu, Powell, Baker, Hogarth, Kahn, Andrews, Berndt: Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. in Blood 2007 (PubMed)

More Antibodies against GP6 Interaction Partners

Mouse (Murine) Glycoprotein VI (Platelet) (GP6) interaction partners

  1. Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size.

  2. These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  3. data demonstrate that genetic deletion of GPVI receptor, FcRgamma (show FCER1G Antibodies) chain, or the alpha2beta1 integrin changes the thrombotic potentials of these platelets to collagen dependent on the stimulus mechanism.

  4. data suggest a novel role for FAK (show PTK2 Antibodies) in GPVI-dependent ROS (show ROS1 Antibodies) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Antibodies) within the GPVI pathway.

  5. our results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.

  6. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin (show F2 Antibodies) generation and (2) recruitment of circulating platelets to clots.

  7. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2 (show TSG101 Antibodies)(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma (show FCER1G Antibodies)-chain and the C-type lectinlike receptor 2 (CLEC-2 (show CLEC1B Antibodies)) signaling

  8. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  9. a delayed and markedly reduced thrombogenic response was still evident in VWF (show VWF Antibodies)(-/-), GPVI, and alpha2beta1 blocked animals, suggesting that alternative primary hemostatic mechanisms can partially rescue the bleeding phenotype associated with these defects.

  10. RhoG is expressed and activated in platelets, plays an important role in GPVI-Fc receptor gamma-chain (show FCER1G Antibodies) complex-mediated platelet activation, and is critical for thrombus formation in vivo.

Human Glycoprotein VI (Platelet) (GP6) interaction partners

  1. results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage

  2. These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  3. data suggest a novel role for FAK (show PTK2 Antibodies) in GPVI-dependent ROS (show ROS1 Antibodies) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Antibodies) within the GPVI pathway.

  4. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin (show F2 Antibodies) generation and (2) recruitment of circulating platelets to clots.

  5. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  6. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 (show ADAMTS13 Antibodies) and those were significantly reduced after plasma exchange.

  7. Results suggest that variants of GP6 SNPs, namely, rs1671153, rs1654410, rs1654419, and rs1613662, may be associated with risk of recurrent miscarriage.

  8. Lower platelet GPIV (show CD36 Antibodies) levels are associated with no-reflow phenomenon in patients with acute myocardial infarction.

  9. Studies indicate that Megakaryocyte maturation is accompanied by up-regulation of glycoprotein VI and down-regulation of leukocyte-associated immunoglobulin-like receptor-1 (show LAIR1 Antibodies).

  10. The identification of four unrelated homozygous patients with an identical defect suggests that inherited GPVI deficiency is more frequent than previously suspected, at least in Chile

GP6 Antigen Profile

Protein Summary

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with GP6

  • glycoprotein VI (platelet) (GP6) antibody
  • glycoprotein 6 (platelet) (Gp6) antibody
  • 9830166G18Rik antibody
  • BDPLT11 antibody
  • Gm469 antibody
  • GPIV antibody
  • GPVI antibody

Protein level used designations for GP6

glycoprotein VI (platelet) , glycoprotein 5 , platelet glycoprotein VI , glycoprotein 6 , platelet collagen receptor

GENE ID SPECIES
456429 Pan troglodytes
484303 Canis lupus familiaris
243816 Mus musculus
51206 Homo sapiens
100141420 Sus scrofa
101123066 Ovis aries
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